Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Christopher J. Schofield"'
Autor:
Malcolm G. P. Page, Jürgen Brem, Christopher J. Schofield, Thomas M. Leissing, Pauline A. Lang
Publikováno v:
Antimicrobial Agents and Chemotherapy
β-Lactam antibiotics are presently the most important treatments for infections by pathogenic Escherichia coli, but their use is increasingly compromised by β-lactamases, including the chromosomally encoded class C AmpC serine-β-lactamases (SBLs).
Autor:
Jürgen Brem, Ricky Cain, Karina Calvopiña, Matthew B. Avison, Kate J. Heesom, Christopher J. Schofield, Samar Johnson, James Spencer, Philip Hinchliffe, Colin W. G. Fishwick, Christopher T. Lohans
Publikováno v:
Molecular Microbiology. 106:492-504
Clavulanic acid and avibactam are clinically deployed serine β-lactamase inhibitors, important as a defence against antibacterial resistance. Bicyclic boronates are recently discovered inhibitors of serine and some metallo β-lactamases. Here, we sh
Publikováno v:
Antimicrobial agents and chemotherapy. 61(12)
Metallo-β-lactamases (MBLs) threaten the clinical utility of β-lactam antibiotics by hydrolyzing penicillins, cephalosporins, and carbapenems. Moreover, they can also hydrolyze all clinically used inhibitors (e.g., clavulanic acid, sulbactam, and t
Autor:
Valerie Castillo, Jürgen Brem, Maria F. Mojica, Alejandro J. Vila, Robert A. Bonomo, Leticia I. Llarrull, James Spencer, Magda Kosmopoulou, Ilaria Pettinati, Graciela Mahler, Philip Hinchliffe, Christopher J. Schofield, Mariano M. González
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Pathogenic Gram-negative bacteria resistant to almost all β-lactam antibiotics are a major public health threat. Zn(II)-dependent or metallo-β-lactamases (MBLs) produced by these bacteria inactivate most β-lactam antibiotics, including the carbape
Autor:
Tom Brown, André Luxen, Pauline Macheboeuf, Christopher J. Schofield, Andréa Dessen, Astrid Zervosen, Delphine S Fischer, Bernard Joris
Beta-lactam antibiotics, including penicillins and cephalosporins, inhibit penicillin-binding proteins (PBPs), which are essential for bacterial cell wall biogenesis. Pathogenic bacteria have evolved efficient antibiotic resistance mechanisms that, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00700365279e49ec3752b2bff5849bc1
https://doi.org/10.1038/nchembio.2007.21
https://doi.org/10.1038/nchembio.2007.21
Autor:
Hanna Tarhonskaya, Lynette M. Phee, Emily Flashman, Inga Pfeffer, Christopher J. Schofield, Jürgen Brem, Sarah E. Wilkins, Rebecca E. J. Geffen, David W. Wareham, Anne Makena
Publikováno v:
Journal of Antimicrobial Chemotherapy
OBJECTIVES: Metallo-β-lactamase (MBL)-based resistance is a threat to the use of most β-lactam antibiotics. Multiple variants of the New Delhi MBL (NDM) have recently been reported. Previous reports indicate that the substitutions affect NDM activi
Autor:
Refaat B. Hamed, Christian Ducho, Gomez-Castellanos, Luc Henry, Michael A. McDonough, Christopher J. Schofield
Publikováno v:
Natural product reports. 30(1)
Covering: up to May 2012 The β-lactam antibiotics and related β-lactamase inhibitors are amongst the most important small molecules in clinical use. Most, but not all, β-lactams including penicillins, cephalosporins, and clavulanic acid are produc
Publikováno v:
Tetrahedron Letters. 35:2783-2786
Two enzymes of the clavulanic acid pathway, clavaminic acid synthase (CAS) and proclavaminic acid amidino hydrolase (PAH), were detected in mycelia of Streptomyces antibioticus ssp antibioticus Tu 1718. These enzymes are presumably involved in the bi