Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Kelly A. Whelan"'
Autor:
Alena Klochkova, Adam L. Karami, Annie D. Fuller, Louis R. Parham, Surali R. Panchani, Shruthi Natarajan, Jazmyne L. Jackson, Anbin Mu, Yinfei Tan, Kathy Q. Cai, Andres J. Klein-Szanto, Amanda B. Muir, Marie-Pier Tétreault, Xavier Graña, Kathryn E. Hamilton, Kelly A. Whelan
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 18, Iss 1, Pp 15-40 (2024)
Background & Aims: Autophagy plays roles in esophageal pathologies both benign and malignant. Here, we aim to define the role of autophagy in esophageal epithelial homeostasis. Methods: We generated tamoxifen-inducible, squamous epithelial-specific A
Externí odkaz:
https://doaj.org/article/10798208ac324620b1299c8ac2877db4
Autor:
Louis R. Parham, Patrick A. Williams, Kay Katada, Shaneice K. Nettleford, Priya Chatterji, Kofi K. Acheampong, Charles H. Danan, Xianghui Ma, Lauren A. Simon, Kaitlyn E. Naughton, Rei Mizuno, Tatiana Karakasheva, Emily A. McMillan, Kelly A. Whelan, Donita C. Brady, Sydney M. Shaffer, Kathryn E. Hamilton
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 17, Iss 3, Pp 439-451 (2024)
Background & Aims: The intestinal epithelium interfaces with a diverse milieu of luminal contents while maintaining robust digestive and barrier functions. Facultative intestinal stem cells are cells that survive tissue injury and divide to re-establ
Externí odkaz:
https://doaj.org/article/2d55833f363e489b8c29b533990b04ea
Autor:
Reshu Saxena, Alena Klochkova, Mary Grace Murray, Mohammad Faujul Kabir, Safiyah Samad, Tyler Beccari, Julie Gang, Kishan Patel, Kathryn E. Hamilton, Kelly A. Whelan
Publikováno v:
Cancers, Vol 11, Iss 11, p 1697 (2019)
Esophageal cancer is among the most aggressive forms of human malignancy with five-year survival rates of
Externí odkaz:
https://doaj.org/article/c5135756dbd14edfac8c4c10d50af5f7
Autor:
Manabu Muto, Masataka Shimonosono, Takaaki Arigami, Amanda B. Muir, Masaki Mori, Takashi Kijima, Yuta Kasagi, Shinya Ohashi, Andres J. Klein-Szanto, Prasanna M. Chandramouleeswaran, Narayan G. Avadhani, Itaru Omoto, Shoji Natsugoe, Gregory G. Ginsberg, Seiji Naganuma, Veronique Giroux, Varun Sahu, Yoshiaki Shinden, Osamu Kikuchi, Devraj Basu, J. Alan Diehl, Yasuto Uchikado, Koji Tanaka, Yoshiaki Kita, Yuichiro Doki, Adam J. Bass, Ken Sasaki, Hiroshi Nakagawa, Anil K. Rustgi, Kelly A. Whelan, Takeo Hara
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 1, Pp 73-91 (2019)
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 1, Pp 73-91 (2019)
Background & Aims Oropharyngeal and esophageal squamous cell carcinomas, especially the latter, are a lethal disease, featuring intratumoral cancer cell heterogeneity and therapy resistance. To facilitate cancer therapy in personalized medicine, thre
Publikováno v:
Current Opinion in Pharmacology. 41:12-19
Esophageal squamous cell carcinoma (ESCC) is amongst the most aggressive human malignancies, representing a significant health burden worldwide. Autophagy is an evolutionarily conserved catabolic process that degrades and recycles damaged organelles
Autor:
Kelly A. Whelan, Anbin Mu, Alena Klochkova, Adam Karami, Mary Grace Murray, Mohammad Faujul Kabir
Publikováno v:
Gastroenterology. 160:S-661
Autor:
Kathryn E. Hamilton, Charles Danan, Patrick A. Williams, Xianghui Ma, Brooke Boyer, Kelly A. Whelan, Tatiana A. Karakasheva, Lauren Simon, Louis Parham, Alena Klochkova
Publikováno v:
Gastroenterology. 160:S-97
Publikováno v:
Gastroenterology. 160:S-110
Autor:
Koji Tanaka, Yoshiaki Kita, Jeffrey D. Winkler, Andres J. Klein-Szanto, Douglas S. Darling, Hiroshi Nakagawa, Satish Srinivasan, Manti Guha, Anil K. Rustgi, Ravi K. Amaravadi, Narayan G. Avadhani, Kelly A. Whelan, Mitsuteru Natsuizaka, Prasanna M. Chandramouleeswaran, Shoji Natsugoe
Publikováno v:
Oncogene
High CD44 expression is associated with enhanced malignant potential in esophageal squamous cell carcinoma (ESCC), among the deadliest of all human carcinomas. Although alterations in autophagy and CD44 expression are associated with poor patient out
Autor:
Kathryn E. Hamilton, Lauren Simon, H. R. Sagara Wijeratne, Shun Liang, Stefanie Marti, David Lee, Fernando Cid Samper, Sarah F. Andres, Priya Chatterji, Louis Parham, Premal Shah, Gian Gaetano Tartaglia, Veronique Giroux, Emma Lundsmith, Gary D. Wu, Lillian Chau, Benjamin J. Wilkins, Kelly A. Whelan, Patrick A. Williams, Rei Mizuno
Publikováno v:
EMBO Rep
RNA binding proteins, including IMP1/IGF2BP1, are essential regulators of intestinal development and cancer. Imp1 hypomorphic mice exhibit gastrointestinal growth defects, yet the specific role for IMP1 in colon epithelial repair is unclear. Our prio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b6927d39f6f7d79d1f61f4ec667da68
https://europepmc.org/articles/PMC6549032/
https://europepmc.org/articles/PMC6549032/