Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Gary S Gilkeson"'
Publikováno v:
Arthritis Rheumatol
OBJECTIVE To examine the therapeutic effects of camptothecin (CPT) and topotecan (TPT), inhibitors of transcription factor Fli-1 and topoisomerase, on lupus nephritis in (NZB × NZW)F1 (NZBWF1) mice, and to examine the effects of CPT and TPT on infla
Autor:
Wangbin Ning, Da Cheng, Philip H. Howe, Chuanxiu Bian, Diane L. Kamen, Zhenwu Luo, Xiaoyu Fu, Elizabeth Ogunrinde, Liuqing Yang, Xu Wang, Quan-Zhen Li, Jim Oates, Weiru Zhang, David White, Zhuang Wan, Gary S. Gilkeson, Wei Jiang
Publikováno v:
J Autoimmun
There is an intricate interplay between the microbiome and the immune response impacting development of normal immunity and autoimmunity. However, we do not fully understand how the microbiome affects production of natural-like and pathogenic autoant
Autor:
Melissa E. Munroe, Kendra A. Young, Joel M. Guthridge, Diane L. Kamen, Gary S. Gilkeson, Michael H. Weisman, Mariko L. Ishimori, Daniel J. Wallace, David R. Karp, John B. Harley, Jill M. Norris, Judith A. James
Publikováno v:
Frontiers in immunology. 13
Systemic lupus erythematosus (SLE) is propelled by pathogenic autoantibody (AutoAb) and immune pathway dysregulation. Identifying populations at risk of reaching classified SLE is essential to curtail inflammatory damage. Lupus blood relatives (Rel)
Formal neurocognitive function and anti-N-methyl-D-aspartate receptor antibodies in paediatric lupus
Publikováno v:
Lupus Science and Medicine, Vol 8, Iss 1 (2021)
Lupus Science & Medicine
Lupus Science & Medicine
ObjectiveSLE is a chronic multisystem autoimmune inflammatory disease impacting a number of organs, including the central nervous system (CNS). The pathophysiology of CNS lupus is multifactorial, making diagnosis problematic. Neurocognitive (NC) test
Autor:
Lingxiao, Xu, Lei, Wang, Yumeng, Shi, Yun, Deng, Jim C, Oates, Diane L, Kamen, Gary S, Gilkeson, Fang, Wang, Miaojia, Zhang, Wenfeng, Tan, Betty P, Tsao
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.)REFERENCES. 74(3)
Elevated interleukin-10 (IL-10) levels in patients with systemic lupus erythematosus (SLE) have B cell-promoting effects, contributing to autoantibody production and tissue damage. We aimed to characterize up-regulated IL-10+ B cell subsets and dysre
Autor:
Linyu, Geng, Jian, Zhao, Yun, Deng, Ivan, Molano, Xue, Xu, Lingxiao, Xu, Phillip, Ruiz, Quanzhen, Li, Xuebing, Feng, Miaojia, Zhang, Wenfeng, Tan, Diane L, Kamen, Sang-Cheol, Bae, Gary S, Gilkeson, Lingyun, Sun, Betty P, Tsao
Publikováno v:
Annals of the rheumatic diseases. 81(2)
We previously identified a hypomorphic variant, p.Arg90His (p.R90H) of neutrophil cytosolic factor 1 (Wild type (WT) and KI littermates were assessed for immune profiles and lupus-like features. Disease activity and renal damage of patients with SLE
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.). 71(12)
Autor:
Kendra A. Young, Jill M. Norris, J. B. Harley, David R. Karp, Deirdra R. Terrell, Judith A. James, Diane L. Kamen, Gary S. Gilkeson, Mariko L. Ishimori, V. M. Holers, Michael H. Weisman, Joel M. Guthridge
Publikováno v:
Lupus. 23:360-369
Objective The objective of this paper is to examine whether smoking is associated with autoantibody production in systemic lupus erythematosus (SLE) patients, unaffected first-degree relatives (FDR) of individuals with SLE—a group at increased risk
Autor:
Liwei Lu, Nan Che, Yayi Hou, Jing Huang, Dandan Wang, Gary S. Gilkeson, Xiaolei Ma, Lingyun Sun, Jun Liang, Zhifeng Gu
Publikováno v:
Cell Transplantation, Vol 22 (2013)
Recent evidence indicates that bone marrow-derived mesenchymal stem cells (BM-MSCs) possess immunosuppressive properties both in vitro and in vivo. We have previously demonstrated that transplantation of human MSCs can significantly improve the autoi
Autor:
Melissa E, Munroe, Kendra A, Young, Diane L, Kamen, Joel M, Guthridge, Timothy B, Niewold, Karen H, Costenbader, Michael H, Weisman, Mariko L, Ishimori, Daniel J, Wallace, Gary S, Gilkeson, David R, Karp, John B, Harley, Jill M, Norris, Judith A, James
Publikováno v:
Arthritisrheumatology (Hoboken, N.J.). 69(3)
Systemic lupus erythematosus (SLE) and other autoimmune diseases cause significant morbidity. Identifying populations at risk of developing SLE is essential for curtailing irreversible inflammatory damage. The aim of this study was to identify factor