Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Yassine Amrani"'
Autor:
Marwa M. E. Mohamed, Yassine Amrani
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 11, p 6170 (2024)
Obese patients with asthma present with aggravated symptoms that are also harder to treat. Here, we used a mouse model of allergic asthma sensitised and challenged to house dust mite (HDM) extracts to determine whether high-fat-diet consumption would
Externí odkaz:
https://doaj.org/article/cd52604d2457443ab5e23c6c6d59c9da
Publikováno v:
Free Radical Biology and Medicine. 185:97-119
The airway smooth muscle (ASM) surrounding the airways is dysfunctional in both asthma and chronic obstructive pulmonary disease (COPD), exhibiting; increased contraction, increased mass, increased inflammatory mediator release and decreased corticos
Autor:
Abdulrahman, Alzahrani, Aamir, Hussain, Fahad, Alhadian, Jameel, Hakeem, Sana, Douaoui, Omar, Tliba, Peter, Bradding, Yassine, Amrani
Publikováno v:
Advances in experimental medicine and biology. 1303
The mechanisms driving corticosteroid insensitivity in asthma are still unclear although evidence points toward a potential role of lung mast cells. Indeed, a number of in vitro studies using various cell types showed that different mediators produce
Autor:
Aamir Hussain, Fahad Alhadian, Peter Bradding, Omar Tliba, Yassine Amrani, Abdulrahman Alzahrani, Jameel Hakeem, Sana Douaoui
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9783030630454
The mechanisms driving corticosteroid insensitivity in asthma are still unclear although evidence points toward a potential role of lung mast cells. Indeed, a number of in vitro studies using various cell types showed that different mediators produce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1228dcc6f4009e6f9d0ef6306de8170a
https://doi.org/10.1007/978-3-030-63046-1_1
https://doi.org/10.1007/978-3-030-63046-1_1
Autor:
Peter Bradding, Yassine Amrani, Christopher E. Brightling, Katherine Clark, Katy M. Roach, Panayiota Stylianou, Dawn T. Smallwood, Bibek Gooptu
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Scientific Reports
Scientific Reports
Chronic obstructive pulmonary disease (COPD) constitutes a major cause of morbidity and mortality. Genome wide association studies have shown significant associations between airflow obstruction or COPD with a non-synonymous SNP in the TNS1 gene, whi
Publikováno v:
Immunobiology
Airway remodeling in asthma manifests, in part, as enhanced airway smooth muscle (ASM) mass, due to myocyte proliferation. While the anti-proliferative effects of glucocorticoid (GC) were investigated in normal ASM cells (NASMC), little is known abou
Autor:
Dedmer Schaafsma, Klaudia Kaczmarek, Patricia Ramos-Ramírez, Yassine Amrani, Omar Tliba, Reynold A. Panettieri
Publikováno v:
Pharmacol Ther
Glucocorticoids (GCs) are the treatment of choice for chronic inflammatory diseases such as asthma. Despite proven effective anti-inflammatory and immunosuppressive effects, long-term and/or systemic use of GCs can potentially induce adverse effects.
Publikováno v:
American Journal of Respiratory Cell and Molecular Biology. 53:728-737
Preclinical models of human conditions including asthma showed the therapeutic potential of Compound A (CpdA), a dissociated glucocorticoid (GC) receptor (GRα) ligand. Whether CpdA inhibits GC resistance, a central feature of severe asthma, has not
Autor:
Rennolds S. Ostrom, Reynod A. Panettieri, Yassine Amrani, Cynthia J. Koziol-White, Dedmer Schaafsma, Omar Tliba
Publikováno v:
Trends in pharmacological sciences. 40(1)
Glucocorticoid (GC) anti-inflammatory effects generally require a prolonged onset of action and involve genomic processes. Because of the rapidity of some of the GC effects, however, the concept that non-genomic actions may contribute to GC mechanism
Autor:
Peter Bradding, Latifa Chachi, Yassine Amrani, Reynold A. Panettieri, Cynthia Koziol-White, Abdulrahman Alzahrani, Michael Biddle, Rehab Bagadood
Publikováno v:
Clinical and experimental immunology. 194(2)
Summary The purpose of this study was to investigate whether growth factors produced by activated human lung mast cells (HLMCs) impair β2-adrenoceptor (β2-AR) function in human airway smooth muscle (ASM) cells. Protein array analysis confirmed the