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Autor:
White, Jon, Sofat, Reecha, Hemani, Gibran, Shah, Tina, Engmann, Jorgen, Dale, Caroline, Shah, Sonia, Kruger, Felix A, Giambartolomei, Claudia, Swerdlow, Daniel I, Palmer, Tom, McLachlan, Stela, Langenberg, Claudia, Zabaneh, Delilah, Lovering, Ruth, Cavadino, Alana, Jefferis, Barbara, Finan, Chris, Wong, Andrew, Amuzu, Antoinette, Ong, Ken, Gaunt, Tom R, Warren, Helen, Davies, Teri-Louise, Drenos, Fotios, Cooper, Jackie, Ebrahim, Shah, Lawlor, Debbie A, Talmud, Philippa J, Humphries, Steve E, Power, Christine, Hypponen, Elina, Richards, Marcus, Hardy, Rebecca, Kuh, Diana, Wareham, Nicholas, Ben-Shlomo, Yoav, Day, Ian N, Whincup, Peter, Morris, Richard, Strachan, Mark W J, Price, Jacqueline, Kumari, Meena, Kivimaki, Mika, Plagnol, Vincent, Whittaker, John C, Smith, George Davey, Dudbridge, Frank, Casas, Juan P, Holmes, Michael V, Hingorani, Aroon D
Publikováno v:
White, J, Sofat, R, Hemani, G, Shah, T, Engmann, J, Dale, C, Shah, S, Kruger, F A, Giambartolomei, C, Swerdlow, D I, Palmer, T, McLachlan, S, Langenberg, C, Zabaneh, D, Lovering, R, Cavadino, A, Jefferis, B, Finan, C, Wong, A, Amuzu, A, Ong, K, Gaunt, T R, Warren, H, Davies, T-L, Drenos, F, Cooper, J, Ebrahim, S, Lawlor, D A, Talmud, P J, Humphries, S E, Power, C, Hypponen, E, Richards, M, Hardy, R, Kuh, D, Wareham, N, Ben-Shlomo, Y, Day, I N, Whincup, P, Morris, R, Strachan, M W J, Price, J, Kumari, M, Kivimaki, M, Plagnol, V, Whittaker, J C, Smith, G D, Dudbridge, F & Casas, J P & Holmes, M V & Hingorani, A D 2016, ' Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysis ', The Lancet Diabetes and Endocrinology, vol. 4, no. 4, pp. 327-336 . https://doi.org/10.1016/S2213-8587(15)00386-1
The Lancet. Diabetes & Endocrinology
The Lancet. Diabetes & Endocrinology
BACKGROUND: Increased circulating plasma urate concentration is associated with an increased risk of coronary heart disease, but the extent of any causative effect of urate on risk of coronary heart disease is still unclear. In this study, we aimed t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ed9ae4ffeb269ecfd551afef8866587a
https://doi.org/10.1016/s2213-8587(15)00386-1
https://doi.org/10.1016/s2213-8587(15)00386-1
Autor:
Schmidt, Amand F., Swerdlow, Daniel I., Holmes, Michael V., Patel, Riyaz S., Fairhurst-Hunter, Zammy, Lyall, Donald M., Hartwig, Fernando Pires, Horta, Bernardo Lessa, Hyppönen, Elina, Power, Christine, Moldovan, Max, van Iperen, Erik, Hovingh, G. Kees, Demuth, Ilja, Norman, Kristina, Steinhagen-Thiessen, Elisabeth, Demuth, Juri, Bertram, Lars, Liu, Tian, Coassin, Stefan, Willeit, Johann, Kiechl, Stefan, Willeit, Karin, Mason, Dan, Wright, John, Morris, Richard, Wanamethee, Goya, Whincup, Peter, Ben-Shlomo, Yoav, McLachlan, Stela, Price, Jackie F., Kivimaki, Mika, Welch, Catherine, Sanchez-Galvez, Adelaida, Marques-Vidal, Pedro, Nicolaides, Andrew, Panayiotou, Andrie G., Onland-Moret, N. Charlotte, van der Schouw, Yvonne T., Matullo, Giuseppe, Fiorito, Giovanni, Guarrera, Simonetta, Sacerdote, Carlotta, Wareham, Nicholas J., Langenberg, Claudia, Scott, Robert, Luan, Jian'an, Bobak, Martin, Malyutina, Sofia, Pająk, Andrzej, Kubinova, Ruzena, Tamosiunas, Abdonas, Pikhart, Hynek, Husemoen, Lise Lotte Nystrup, Garup, Niels, Pedersen, Oluf, Hansen, Torben, Linneberg, Allan, Simonsen, Kenneth Starup, Cooper, Jackie, Humphries, Steve E., Brilliant, Murray, Kitchner, Terrie, Hakonarson, Hakon, Carrell, David S., McCarty, Catherine A., Kirchner, H. Lester, Larson, Eric B., Crosslin, David R., de Andrade, Mariza, Roden, Dan M., Denny, Joshua C., Carty, Cara, Hancock, Stephen, Attia, John, Holliday, Elizabeth, O'Donnell, Martin, Yusuf, Salim, Chong, Michael, Pare, Guillaume, van der Harst, Pim, Said, M. Abdullah, Eppinga, Ruben N., Verweij, Niek, Snieder, Harold, Christen, Tim, Mook-Kanamori, Dennis O., Gustafsson, Stefan, Lind, Lars, Ingelsson, Erik, Pazoki, Raha, Franco, Oscar, Hofman, Albert, Uitterlinden, Andre, Dehghan, Abbas, Teumer, Alexander, Baumeister, Sebastian, Dörr, Marcus, Lerch, Markus M., Völker, Uwe, Völzke, Henry, Ward, Joey, Pell, Jill P., Smith, Daniel J., Meade, Tom, Maitland-van der Zee, Anke H., Baranova, Ekaterina V., Young, Robin, Ford, Ian, Campbell, Archie, Padmanabhan, Sandosh, Bots, Michiel L., Grobbee, Diederick E., Froguel, Philippe, Thuillier, Dorothée, Balkau, Beverley, Bonnefond, Amélie, Cariou, Bertrand, Smart, Melissa, Bao, Yanchun, Kumari, Meena, Mahajan, Anubha, Ridker, Paul M., Chasman, Daniel I., Reiner, Alex P., Lange, Leslie A., Ritchie, Marylyn D., Asselbergs, Folkert, Casas, Juan-Pablo, Keating, Brendan J., Preiss, David, Hingorani, Aroon D., Sattar, Naveed
Publikováno v:
The Lancet Diabetes & Endocrinology
Schmidt, A F, Swerdlow, D I, Holmes, M V, Patel, R S, Fairhurst-hunter, Z, Lyall, D M, Hartwig, F P, Horta, B L, Hyppönen, E, Power, C, Moldovan, M, Van Iperen, E, Hovingh, G K, Demuth, I, Norman, K, Steinhagen-thiessen, E, Demuth, J, Bertram, L, Liu, T, Coassin, S, Willeit, J, Kiechl, S, Willeit, K, Mason, D, Wright, J, Morris, R, Wanamethee, G, Whincup, P, Ben-shlomo, Y, Mclachlan, S, Price, J F, Kivimaki, M, Welch, C, Sanchez-galvez, A, Marques-vidal, P, Nicolaides, A, Panayiotou, A G, Onland-moret, N C, Van Der Schouw, Y T, Matullo, G, Fiorito, G, Guarrera, S, Sacerdote, C, Wareham, N J, Langenberg, C, Scott, R, Luan, J, Bobak, M, Malyutina, S, Pająk, A, Kubinova, R, Tamosiunas, A, Pikhart, H, Husemoen, L L N, Grarup, N, Pedersen, O, Hansen, T, Linneberg, A, Simonsen, K S, Cooper, J, Humphries, S E, Brilliant, M, Kitchner, T, Hakonarson, H, Carrell, D S, Mccarty, C A, Kirchner, H L, Larson, E B, Crosslin, D R, De Andrade, M, Roden, D M, Denny, J C, Carty, C, Hancock, S, Attia, J, Holliday, E, Donnell, M O, Yusuf, S, Chong, M, Pare, G, Van Der Harst, P, Said, M A, Eppinga, R N, Verweij, N, Snieder, H, Christen, T, Mook-kanamori, D O, Gustafsson, S, Lind, L, Ingelsson, E, Pazoki, R, Franco, O, Hofman, A, Uitterlinden, A, Dehghan, A, Teumer, A, Baumeister, S, Dörr, M, Lerch, M M, Völker, U, Völzke, H, Ward, J, Pell, J P, Smith, D J, Meade, T, Maitland-van Der Zee, A H, Baranova, E V, Young, R, Ford, I, Campbell, A, Padmanabhan, S, Bots, M L, Grobbee, D E, Froguel, P, Thuillier, D, Balkau, B, Bonnefond, A, Cariou, B, Smart, M, Bao, Y, Kumari, M, Mahajan, A, Ridker, P M, Chasman, D I, Reiner, A P, Lange, L A, Ritchie, M D, Asselbergs, F W, Casas, J, Keating, B J, Preiss, D, Hingorani, A D & Sattar, N 2016, ' PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study ', The Lancet Diabetes and Endocrinology . https://doi.org/10.1016/S2213-8587(16)30396-5
The lancet. Diabetes & endocrinology, vol. 5, no. 2, pp. 97-105
Schmidt, A F, Swerdlow, D I, Holmes, M V, Patel, R S, Fairhurst-Hunter, Z, Lyall, D M, Hartwig, F P, Horta, B L, Hyppönen, E, Power, C, Moldovan, M, van Iperen, E, Hovingh, G K, Demuth, I, Norman, K, Steinhagen-Thiessen, E, Demuth, J, Bertram, L, Liu, T, Coassin, S, Willeit, J, Kiechl, S, Willeit, K, Mason, D, Wright, J, Morris, R, Wanamethee, G, Whincup, P, Ben-Shlomo, Y, McLachlan, S, Price, J F, Kivimaki, M, Welch, C, Sanchez-Galvez, A, Marques-Vidal, P, Nicolaides, A, Panayiotou, A G, Onland-Moret, N C, van der Schouw, Y T, Matullo, G, Fiorito, G, Guarrera, S, Sacerdote, C, Wareham, N J, Langenberg, C, Scott, R, Luan, J, Bobak, M, Malyutina, S, Pajak, A, Kubinova, R, Tamosiunas, A, Pikhart, H, Husemoen, L L N, Grarup, N, Pedersen, O, Hansen, T, Linneberg, A, Simonsen, K S, Cooper, J, Humphries, S E, Brilliant, M, Kitchner, T, Hakonarson, H, Carrell, D S, McCarty, C A, Kirchner, H L, Larson, E B, Crosslin, D R, de Andrade, M, Roden, D M, Denny, J C, Carty, C, Hancock, S, Attia, J, Holliday, E, Donnell, M O, Yusuf, S, Chong, M, Pare, G, van der Harst, P, Said, M A, Eppinga, R N, Verweij, N, Snieder, H, Christen, T, Mook-Kanamori, D O, Gustafsson, S, Lind, L, Ingelsson, E, Pazoki, R, Franco, O, Hofman, A, Uitterlinden, A, Dehghan, A, Teumer, A, Baumeister, S, Dörr, M, Lerch, M M, Völker, U, Völzke, H, Ward, J, Pell, J P, Smith, D J, Meade, T, Maitland-van der Zee, A H, Baranova, E V, Young, R, Ford, I, Campbell, A, Padmanabhan, S, Bots, M L, Grobbee, D E, Froguel, P, Thuillier, D, Balkau, B, Bonnefond, A, Cariou, B, Smart, M, Bao, Y, Kumari, M, Mahajan, A, Ridker, P M, Chasman, D I, Reiner, A P, Lange, L A, Ritchie, M D, Asselbergs, F W, Casas, J P, Keating, B J, Preiss, D, Hingorani, A D & Sattar, N 2017, ' PCSK9 genetic variants and risk of type 2 diabetes : a Mendelian randomisation study ', Lancet Diabetes and Endocrinology, vol. 5, no. 2, pp. 97-105 . https://doi.org/10.1016/S2213-8587(16)30396-5
The Lancet Diabetes & Endocrinology, 5(2), 97–105. Elsevier BV
The Lancet Diabetes & Endocrinology, 5(2), 97-105. Elsevier
Schmidt, A F, Swerdlow, D I, Holmes, M V, Patel, R S, Fairhurst-Hunter, Z, Lyall, D M, Hartwig, F P, Horta, B L, Hyppönen, E, Power, C, Moldovan, M, van Iperen, E, Hovingh, G K, Demuth, I, Norman, K, Steinhagen-Thiessen, E, Demuth, J, Bertram, L, Liu, T, Coassin, S, Willeit, J, Kiechl, S, Willeit, K, Mason, D, Wright, J, Morris, R, Wanamethee, G, Whincup, P, Ben-Shlomo, Y, McLachlan, S, Price, J F, Kivimaki, M, Welch, C, Sanchez-Galvez, A, Marques-Vidal, P, Nicolaides, A, Panayiotou, A G, Onland-Moret, N C, van der Schouw, Y T, Matullo, G, Fiorito, G, Guarrera, S, Sacerdote, C, Wareham, N J, Langenberg, C, Scott, R, Luan, J, Bobak, M, Malyutina, S, Pajak, A, Kubinova, R, Tamosiunas, A, Pikhart, H, Husemoen, L L N, Grarup, N, Pedersen, O, Hansen, T, Linneberg, A, Simonsen, K S, Cooper, J, Humphries, S E, Brilliant, M, Kitchner, T, Hakonarson, H, Carrell, D S, McCarty, C A, Kirchner, H L, Larson, E B, Crosslin, D R, de Andrade, M, Roden, D M, Denny, J C, Carty, C, Hancock, S, Attia, J, Holliday, E, Donnell, M O, Yusuf, S, Chong, M, Pare, G, van der Harst, P, Said, M A, Eppinga, R N, Verweij, N, Snieder, H, Christen, T, Mook-Kanamori, D O, Gustafsson, S, Lind, L, Ingelsson, E, Pazoki, R, Franco, O, Hofman, A, Uitterlinden, A, Dehghan, A, Teumer, A, Baumeister, S, Dörr, M, Lerch, M M, Völker, U, Völzke, H, Ward, J, Pell, J P, Smith, D J, Meade, T, Maitland-van der Zee, A H, Baranova, E V, Young, R, Ford, I, Campbell, A, Padmanabhan, S, Bots, M L, Grobbee, D E, Froguel, P, Thuillier, D, Balkau, B, Bonnefond, A, Cariou, B, Smart, M, Bao, Y, Kumari, M, Mahajan, A, Ridker, P M, Chasman, D I, Reiner, A P, Lange, L A, Ritchie, M D, Asselbergs, F W, Casas, J P, Keating, B J, Preiss, D, Hingorani, A D & Sattar, N 2017, ' PCSK9 genetic variants and risk of type 2 diabetes : a mendelian randomisation study ' vol 5, no. 2, pp. 97-105 . DOI: 10.1016/S2213-8587(16)30396-5
Schmidt, A F, Swerdlow, D I, Holmes, M V, Patel, R S, Fairhurst-hunter, Z, Lyall, D M, Hartwig, F P, Horta, B L, Hyppönen, E, Power, C, Moldovan, M, Van Iperen, E, Hovingh, G K, Demuth, I, Norman, K, Steinhagen-thiessen, E, Demuth, J, Bertram, L, Liu, T, Coassin, S, Willeit, J, Kiechl, S, Willeit, K, Mason, D, Wright, J, Morris, R, Wanamethee, G, Whincup, P, Ben-shlomo, Y, Mclachlan, S, Price, J F, Kivimaki, M, Welch, C, Sanchez-galvez, A, Marques-vidal, P, Nicolaides, A, Panayiotou, A G, Onland-moret, N C, Van Der Schouw, Y T, Matullo, G, Fiorito, G, Guarrera, S, Sacerdote, C, Wareham, N J, Langenberg, C, Scott, R, Luan, J, Bobak, M, Malyutina, S, Pająk, A, Kubinova, R, Tamosiunas, A, Pikhart, H, Husemoen, L L N, Grarup, N, Pedersen, O, Hansen, T, Linneberg, A, Simonsen, K S, Cooper, J, Humphries, S E, Brilliant, M, Kitchner, T, Hakonarson, H, Carrell, D S, Mccarty, C A, Kirchner, H L, Larson, E B, Crosslin, D R, De Andrade, M, Roden, D M, Denny, J C, Carty, C, Hancock, S, Attia, J, Holliday, E, Donnell, M O, Yusuf, S, Chong, M, Pare, G, Van Der Harst, P, Said, M A, Eppinga, R N, Verweij, N, Snieder, H, Christen, T, Mook-kanamori, D O, Gustafsson, S, Lind, L, Ingelsson, E, Pazoki, R, Franco, O, Hofman, A, Uitterlinden, A, Dehghan, A, Teumer, A, Baumeister, S, Dörr, M, Lerch, M M, Völker, U, Völzke, H, Ward, J, Pell, J P, Smith, D J, Meade, T, Maitland-van Der Zee, A H, Baranova, E V, Young, R, Ford, I, Campbell, A, Padmanabhan, S, Bots, M L, Grobbee, D E, Froguel, P, Thuillier, D, Balkau, B, Bonnefond, A, Cariou, B, Smart, M, Bao, Y, Kumari, M, Mahajan, A, Ridker, P M, Chasman, D I, Reiner, A P, Lange, L A, Ritchie, M D, Asselbergs, F W, Casas, J, Keating, B J, Preiss, D, Hingorani, A D & Sattar, N 2016, ' PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study ', The Lancet Diabetes and Endocrinology . https://doi.org/10.1016/S2213-8587(16)30396-5
The lancet. Diabetes & endocrinology, vol. 5, no. 2, pp. 97-105
Schmidt, A F, Swerdlow, D I, Holmes, M V, Patel, R S, Fairhurst-Hunter, Z, Lyall, D M, Hartwig, F P, Horta, B L, Hyppönen, E, Power, C, Moldovan, M, van Iperen, E, Hovingh, G K, Demuth, I, Norman, K, Steinhagen-Thiessen, E, Demuth, J, Bertram, L, Liu, T, Coassin, S, Willeit, J, Kiechl, S, Willeit, K, Mason, D, Wright, J, Morris, R, Wanamethee, G, Whincup, P, Ben-Shlomo, Y, McLachlan, S, Price, J F, Kivimaki, M, Welch, C, Sanchez-Galvez, A, Marques-Vidal, P, Nicolaides, A, Panayiotou, A G, Onland-Moret, N C, van der Schouw, Y T, Matullo, G, Fiorito, G, Guarrera, S, Sacerdote, C, Wareham, N J, Langenberg, C, Scott, R, Luan, J, Bobak, M, Malyutina, S, Pajak, A, Kubinova, R, Tamosiunas, A, Pikhart, H, Husemoen, L L N, Grarup, N, Pedersen, O, Hansen, T, Linneberg, A, Simonsen, K S, Cooper, J, Humphries, S E, Brilliant, M, Kitchner, T, Hakonarson, H, Carrell, D S, McCarty, C A, Kirchner, H L, Larson, E B, Crosslin, D R, de Andrade, M, Roden, D M, Denny, J C, Carty, C, Hancock, S, Attia, J, Holliday, E, Donnell, M O, Yusuf, S, Chong, M, Pare, G, van der Harst, P, Said, M A, Eppinga, R N, Verweij, N, Snieder, H, Christen, T, Mook-Kanamori, D O, Gustafsson, S, Lind, L, Ingelsson, E, Pazoki, R, Franco, O, Hofman, A, Uitterlinden, A, Dehghan, A, Teumer, A, Baumeister, S, Dörr, M, Lerch, M M, Völker, U, Völzke, H, Ward, J, Pell, J P, Smith, D J, Meade, T, Maitland-van der Zee, A H, Baranova, E V, Young, R, Ford, I, Campbell, A, Padmanabhan, S, Bots, M L, Grobbee, D E, Froguel, P, Thuillier, D, Balkau, B, Bonnefond, A, Cariou, B, Smart, M, Bao, Y, Kumari, M, Mahajan, A, Ridker, P M, Chasman, D I, Reiner, A P, Lange, L A, Ritchie, M D, Asselbergs, F W, Casas, J P, Keating, B J, Preiss, D, Hingorani, A D & Sattar, N 2017, ' PCSK9 genetic variants and risk of type 2 diabetes : a Mendelian randomisation study ', Lancet Diabetes and Endocrinology, vol. 5, no. 2, pp. 97-105 . https://doi.org/10.1016/S2213-8587(16)30396-5
The Lancet Diabetes & Endocrinology, 5(2), 97–105. Elsevier BV
The Lancet Diabetes & Endocrinology, 5(2), 97-105. Elsevier
Schmidt, A F, Swerdlow, D I, Holmes, M V, Patel, R S, Fairhurst-Hunter, Z, Lyall, D M, Hartwig, F P, Horta, B L, Hyppönen, E, Power, C, Moldovan, M, van Iperen, E, Hovingh, G K, Demuth, I, Norman, K, Steinhagen-Thiessen, E, Demuth, J, Bertram, L, Liu, T, Coassin, S, Willeit, J, Kiechl, S, Willeit, K, Mason, D, Wright, J, Morris, R, Wanamethee, G, Whincup, P, Ben-Shlomo, Y, McLachlan, S, Price, J F, Kivimaki, M, Welch, C, Sanchez-Galvez, A, Marques-Vidal, P, Nicolaides, A, Panayiotou, A G, Onland-Moret, N C, van der Schouw, Y T, Matullo, G, Fiorito, G, Guarrera, S, Sacerdote, C, Wareham, N J, Langenberg, C, Scott, R, Luan, J, Bobak, M, Malyutina, S, Pajak, A, Kubinova, R, Tamosiunas, A, Pikhart, H, Husemoen, L L N, Grarup, N, Pedersen, O, Hansen, T, Linneberg, A, Simonsen, K S, Cooper, J, Humphries, S E, Brilliant, M, Kitchner, T, Hakonarson, H, Carrell, D S, McCarty, C A, Kirchner, H L, Larson, E B, Crosslin, D R, de Andrade, M, Roden, D M, Denny, J C, Carty, C, Hancock, S, Attia, J, Holliday, E, Donnell, M O, Yusuf, S, Chong, M, Pare, G, van der Harst, P, Said, M A, Eppinga, R N, Verweij, N, Snieder, H, Christen, T, Mook-Kanamori, D O, Gustafsson, S, Lind, L, Ingelsson, E, Pazoki, R, Franco, O, Hofman, A, Uitterlinden, A, Dehghan, A, Teumer, A, Baumeister, S, Dörr, M, Lerch, M M, Völker, U, Völzke, H, Ward, J, Pell, J P, Smith, D J, Meade, T, Maitland-van der Zee, A H, Baranova, E V, Young, R, Ford, I, Campbell, A, Padmanabhan, S, Bots, M L, Grobbee, D E, Froguel, P, Thuillier, D, Balkau, B, Bonnefond, A, Cariou, B, Smart, M, Bao, Y, Kumari, M, Mahajan, A, Ridker, P M, Chasman, D I, Reiner, A P, Lange, L A, Ritchie, M D, Asselbergs, F W, Casas, J P, Keating, B J, Preiss, D, Hingorani, A D & Sattar, N 2017, ' PCSK9 genetic variants and risk of type 2 diabetes : a mendelian randomisation study ' vol 5, no. 2, pp. 97-105 . DOI: 10.1016/S2213-8587(16)30396-5
Background: Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions\ud in both the concentration of LDL cholesterol and the risk of coronary heart disease, but also with modest\ud hyperglycaemia, increased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2812e52dbda4c9ea64776e57223922ea
https://hdl.handle.net/20.500.14279/10079
https://hdl.handle.net/20.500.14279/10079
Autor:
Sofat, Reecha, Cooper, Jackie A., Kumari, Meena, Casas, Juan P., Mitchell, Jacqueline P., Acharya, Jayshree, Thom, Simon, Hughes, Alun D., Humphries, Steve E., Hingorani, Aroon D.
Publikováno v:
PLoS Medicine
PLoS Medicine, Vol 13, Iss 10, p e1002146 (2016)
PLoS Medicine, Vol 13, Iss 10, p e1002146 (2016)
Background The association of APOE genotype with circulating apolipoprotein E (ApoE) concentration and cardiovascular disease (CVD) risk is well established. However, the relationship of circulating ApoE concentration and CVD has received little atte