Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Ye Zheng"'
Autor:
Jinhyuk Choi, Tae Gyu Oh, Hee-Won Jung, Kun-Young Park, Hyemi Shin, Taehee Jo, Du-Seock Kang, Dipanjan Chanda, Sujung Hong, Jina Kim, Hayoung Hwang, Moongi Ji, Minkyo Jung, Takashi Shoji, Ayami Matsushima, Pilhan Kim, Ji Young Mun, Man-Jeong Paik, Sung Jin Cho, In-Kyu Lee, David C. Whitcomb, Phil Greer, Brandon Blobner, Mark O. Goodarzi, Stephen J. Pandol, Jerome I. Rotter, Weiwei Fan, Sagar P. Bapat, Ye Zheng, Chris Liddle, Ruth T. Yu, Annette R. Atkins, Michael Downes, Eiji Yoshihara, Ronald M. Evans, Jae Myoung Suh
Publikováno v:
Gastroenterology
BACKGROUND & AIMS: Mitochondrial dysfunction disrupts the synthesis and secretion of digestive enzymes in pancreatic acinar cells and plays a primary role in the etiology of exocrine pancreas disorders. However, the transcriptional mechanisms that re
Publikováno v:
bioRxiv
SUMMARYChromatin conformation reorganization is emerging as an important layer of regulation for gene expression and lineage specification. Yet, how lineage-specific transcription factors contribute to the establishment of cell type-specific 3D chrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::315c5e375601aa04830bd3e89cb85464
https://doi.org/10.1101/2023.02.22.529589
https://doi.org/10.1101/2023.02.22.529589
Autor:
Ryan C. Gimple, Guoxin Zhang, Linjie Zhao, Leo J.Y. Kim, Jia Z. Shen, Cheryl Kim, Briana C. Prager, Xujun Wang, Jean A. Bernatchez, Xiang-Dong Fu, Jeremy N. Rich, Kailin Yang, Jair L. Siqueira-Neto, Deobrat Dixit, Zhixin Qiu, Lukas Chavez, Zhe Zhu, Deguan Lv, Ye Zheng, Denise Hinz, Zhengyu Liang, Charles Spruck, Xiuxing Wang, Chunyu Jin, Qiyuan Yang, Qiulian Wu, Lihua Min, Katherine A. Jones, Zhen Dong, Shruti Bhargava
Publikováno v:
Cancer Discov
Glioblastoma (GBM) is the most lethal primary brain cancer characterized by therapeutic resistance, which is promoted by GBM stem cells (GSC). Here, we interrogated gene expression and whole-genome CRISPR/Cas9 screening in a large panel of patient-de
Autor:
Xiao Ma, Seethalakshmi R. Iyer, Xiaoyu Ma, Shawn H. Reginauld, Yang Chen, Shuchong Pan, Ye Zheng, Dante Moroni, Yue Yu, Lianwen Zhang, Valentina Cannone, Horng H. Chen, Carlos M. Ferrario, S. Jeson Sangaralingham, John C. Burnett
Publikováno v:
bioRxiv
BackgroundNatriuretic peptide system (NPS) and renin angiotensin aldosterone system (RAAS) function oppositely at multiple levels. While it has long been suspected that angiotensin II (ANGII) may directly suppress NPS activity, no clear evidence to d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40bf660fcf7fdac60d9ed89d650b9e3e
https://europepmc.org/articles/PMC9901178/
https://europepmc.org/articles/PMC9901178/
Publikováno v:
Methods
High-throughput genome-wide chromatin conformation capture assay (Hi-C) is routinely used to profile long-range genomic interactions and three-dimensional organization of genomes. A key application of Hi-C is the comparative analysis of genomic inter
Autor:
Whitehouse, Daniel, Monteiro, Miguel, Czeiter, Endre, Vyvere, Thijs Vande, Valerio, Fernanda, Ye, Zheng, Amrein, Krisztina, Kamnitsas, Konstantinos, Xu, Haiyan, Yang, Zhihui, Verheyden, Jan, Newcombe, Virginia F.J., Andelic, Nada, Andreassen, Lasse, Vik, Anne, Anke, Audny Gabriele Wagner, Helseth, Eirik, Skandsen, Toril, Røe, Cecilie, Røise, Olav, Frisvold, Shirin, Antoni, Anna, Audibert, Gerard, Azouvi, Philippe, Azzolini, Maria Luisa, Bartels, Ronald, Barzó, Pál, Beauvais, Romuald, Beer, Ronny, Bellander, Bo-Michael, Belli, Antonio, Benali, Habib, Berardino, Maurizio, Beretta, Luigi, Blaabjerg, Morten, Bragge, Peter, Brazinova, Alexandra, Brinck, Vibeke, Brooker, Joanne, Brorsson, Camilla, Buki, Andras, Bullinger, Monika, Cabeleira, Manuel, Caccioppola, Alessio, Calappi, Emiliana, Calvi, Maria Rosa, Cameron, Peter, Lozano, Guillermo Carbayo, Carbonara, Marco, Castaño-León, Ana M.
Publikováno v:
EBioMedicine
EBioMedicine, 75:103777. Elsevier
EBioMedicine, Vol 75, Iss, Pp 103777-(2022)
EBioMedicine, 75. ELSEVIER
EBioMedicine, 75:103777. Elsevier
EBioMedicine, Vol 75, Iss, Pp 103777-(2022)
EBioMedicine, 75. ELSEVIER
Background: We aimed to understand the relationship between serum biomarker concentration and lesion type and volume found on computed tomography (CT) following all severities of TBI. Methods: Concentrations of six serum biomarkers (GFAP, NFL, NSE, S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a581132c7d935630c359fe52e199f467
https://hdl.handle.net/11250/3054022
https://hdl.handle.net/11250/3054022
Publikováno v:
Nat Immunol
Maintenance of tissue homeostasis is dependent on the communication between stem cells and supporting cells in the same niche. Regulatory T cells (Treg) are a critical component of the stem cell niche to support their differentiation. How Treg cells
Autor:
Sela T. Po'uha, Francesca Walker, Ian P. Street, Jamie I. Fletcher, Janet Weinstock, Meng Xiao Luo, Jayne Murray, Marie Liesse Asselin-Labat, Kristy Shield-Artin, Ye Zheng, Clare E. Weeden, Alvin Kamili, Anderly C. Chueh, Chin Wee Tan, Gregor Ebert, Mark G. Devlin, Maree C. Faux, Clare L. Scott, Michelle Haber, Helen Witchard, Esmee Broekhuizen, Matthew Wakefield, Nadia J. Kershaw, Jane E. Visvader, Serena R Kane, Geoffrey J. Lindeman, Judy Doherty, Susan A. Charman, Antony W. Burgess, Maria Kavallaris, François Vaillant, Keith G. Watson, Christoph Grohmann, Gwo-Yaw Ho, Guillaume Lessene
Publikováno v:
Cell Death & Disease
Cell Death and Disease, Vol 12, Iss 3, Pp 1-18 (2021)
Cell Death and Disease, Vol 12, Iss 3, Pp 1-18 (2021)
Targeting cell division by chemotherapy is a highly effective strategy to treat a wide range of cancers. However, there are limitations of many standard-of-care chemotherapies: undesirable drug toxicity, side-effects, resistance and high cost. New sm
Autor:
Rebecca S. LaRue, Louisa E. Sjaastad, Mark S. Anderson, Calvin B. Williams, Praful Aggarwal, Maria-Luisa Alegre, Ulrich Broeckel, Shawn A. Mahmud, Irina Proekt, Dimitre R. Simeonov, Jason B. Williams, Michael A. Farrar, Weishan Huang, Jonathan C. Jeschke, Corey N. Miller, Roland Ruscher, David L. Owen, Christine Henzler, Justin A. Spanier, Can Hekim, Avery August, Alexander Marson, Ye Zheng
Publikováno v:
Nature immunology
The developmental programs that generate a broad repertoire of regulatory T cells (Treg cells) able to respond to both self antigens and non-self antigens remain unclear. Here we found that mature Treg cells were generated through two distinct develo
Autor:
Anoop P. Patel, Ye Zheng, Raphael Gottardo, Abdullah H. Feroze, Samuel Emerson, Scott N. Furlan, Jay F. Sarthy, Kalee Carson, Steven J. Wu, Hatice S. Kaya-Okur, Patrick J. Cimino, C. Dirk Keene, Kami Ahmad, Anca Mihalas, Steven Henikoff
Publikováno v:
Nat Biotechnol
Methods for quantifying gene expression1 and chromatin accessibility2 in single cells are well established, but single-cell analysis of chromatin regions with specific histone modifications has been technically challenging. In this study, we adapted