Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Takeshi Teramura"'
Autor:
Toshiyuki Takehara, Kanji Fukuda, Yuta Onodera, Takatoshi Tsujimoto, Shinichi Nakao, Takeshi Teramura, Kei Houri, Tatsufumi Mori
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Elevation of the levels of reactive oxygen species (ROS) is a major tissue-degenerative phenomenon involved in aging and aging-related diseases. The detailed mechanisms underlying aging-related ROS generation remain unclear. Presently, the expression
Publikováno v:
FEBS Open Bio
FEBS Open Bio, Vol 5, Iss 1, Pp 476-484 (2015)
FEBS Open Bio, Vol 5, Iss 1, Pp 476-484 (2015)
Highlights • Hyaluronic acid (HA) has a pharmacological role for reduction of cellular superoxide. • In HA-treated chondrocytes, expression of Nrf2 and its downstream genes was upregulated. • Inhibition of Akt or suppression of HA receptors pre
Autor:
Takuro Horii, Merissa Olmer, Toshiyuki Takehara, Hiroshi Asahara, Takeshi Teramura, Izuho Hatada, Yuta Onodera, Kanji Fukuda, Martin Lotz, Joe Hasei, Toshifumi Ozaki
Publikováno v:
Scientific Reports
The objective was to investigate the levels of TWIST1 in normal and OA cartilage and examine its role in regulating gene expression in chondrocytes. Human cartilage tissues and chondrocytes were obtained at autopsy from normal knee joints and from OA
Autor:
Yuta Onodera, Joe Hasei, Toshifumi Ozaki, Takeshi Teramura, Kanji Fukuda, Toshiyuki Takehara, John P. Frampton, Kayoko Obora
Publikováno v:
Scientific Reports
Intracerebral inflammation resulting from injury or disease is implicated in disruption of neural regeneration and may lead to irreversible neuronal dysfunction. Analysis of inflammation-related microRNA profiles in various tissues, including the bra
Autor:
R. Akagi, Oscar Alvarez-Garcia, Kathleen M. Fisch, Andrew I. Su, Y. Muramatsu, Martin Lotz, Yorikazu Akatsu, Takahisa Sasho, Masahiko Saito, Takeshi Teramura
Publikováno v:
Osteoarthritis and cartilage. 25(6)
Summary Objectives Circadian rhythm (CR) was identified by RNA sequencing as the most dysregulated pathway in human osteoarthritis (OA) in articular cartilage. This study examined circadian rhythmicity in cultured chondrocytes and the role of the CR
Publikováno v:
Scientific Reports
The cell adhesion molecule Cadherin 2 (Cdh2) plays important roles in somatic cell adhesion, proliferation and migration. Cdh2 is also highly expressed in mouse epiblast stem cells (mEpiSCs), but its function in these cells is unknown. To understand
Publikováno v:
FEBS Open Bio
FEBS Open Bio, Vol 5, Iss 1, Pp 492-501 (2015)
FEBS Open Bio, Vol 5, Iss 1, Pp 492-501 (2015)
Highlights • Oxidative stress in the arthritis joint is involved in generating mediators for inflammation. • Oxidative stress-induced expression of Cox-2 was mediated by MAPKs and NF-κB. • ROS-induced MAPKs and NF-κB were attenuated by inhibi
Autor:
Kazuhiro Ohtani, Masao Akagi, Toshiyuki Takehara, Ichiro Tsukamoto, Takeshi Teramura, Shinji Inoue
Publikováno v:
FEBS Open Bio
A local tissue-specific renin–angiotensin system (local RAS) has been identified in many organs. However, no report has described the role of a local RAS in the hypertrophic differentiation of chondrocytes. To examine the role of a local RAS in the