Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Tadanobu Nagaya"'
Publikováno v:
Digestion
Background: Cancers of the gastrointestinal (GI) tract are the common leading cause of cancer-related death in the world. Recent advances in cancer therapies such as intensive multidrug chemotherapy and molecular targeted treatment have improved ther
Autor:
Aki Furusawa, Takuya Kato, Ryuhei Okada, Daiki Fujimura, Hiroaki Wakiyama, Tadanobu Nagaya, Hisataka Kobayashi, Yasuhiro Maruoka, Peter L. Choyke, Fuyuki Inagaki
Publikováno v:
Cancer Immunol Res
Near-infrared photoimmunotherapy (NIR-PIT) is a newly developed and selective cancer treatment that induces necrotic and immunogenic cell death and utilizes a monoclonal antibody conjugated to a photo-absorber dye, IR700DX, activated by NIR light. Al
Autor:
Tapan K. Bera, Ira Pastan, Chin-Hsien Tai, Zeliang Zheng, William Kuhlman, Junxia Wei, Fred Lee, Qi Zhou, Yun Gao, Hisataka Kobayashi, Tadanobu Nagaya, Ryuhei Okada
Publikováno v:
Mol Cancer Ther
Recombinant immunotoxins (RIT) are chimeric proteins containing an Fv that binds to tumor cells, fused to a fragment of Pseudomonas exotoxin (PE) that kills the cell. Their efficacy is limited by their short half-life in the circulation. Chemical mod
The Effect of Antibody Fragments on CD25 Targeted Regulatory T Cell Near-Infrared Photoimmunotherapy
Autor:
Ryuhei Okada, Daiki Fujimura, Peter L. Choyke, Tadanobu Nagaya, Fuyuki Inagaki, Yasuhiro Maruoka, Aki Furusawa, Hisataka Kobayashi
Publikováno v:
Bioconjug Chem
Regulatory T (Treg) cells play a major role in immune suppression permitting tumors to evade immune surveillance. Depletion of intra-tumoral Treg cells can result in tumor regression. However, systemic depletion of Tregs may also induce autoimmune ad
Autor:
Takeji Umemura, Tadanobu Nagaya, Satoru Joshita, Hiroshi Suzuki, Akihiro Ito, Koichi Sato, Tomoaki Suga
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Percutaneous endoscopic gastrostomy (PEG), which is frequently used for nutrition management in patients having difficulty with oral intake, is considered a safe procedure. However, serious complications may occur depending on site of the puncture. T
Autor:
Tadanobu Nagaya, Takuya Kato, Fuyuki Inagaki, Ryuhei Okada, Hiroaki Wakiyama, Aki Furusawa, Peter L. Choyke, Yasuhiro Maruoka, Hisataka Kobayashi, Daiki Fujimura
Publikováno v:
Vaccines
Volume 8
Issue 3
Vaccines, Vol 8, Iss 528, p 528 (2020)
Volume 8
Issue 3
Vaccines, Vol 8, Iss 528, p 528 (2020)
Near infrared photoimmunotherapy (NIR-PIT) is a newly developed and highly selective cancer treatment that induces necrotic/immunogenic cell death. It employs a monoclonal antibody (mAb) conjugated to a photo-absorber dye, IRDye700DX, which is activa
Autor:
Ryuhei Okada, Fuyuki Inagaki, Hiroaki Wakiyama, Tadanobu Nagaya, Yasuhiro Maruoka, Hisataka Kobayashi, Aki Furusawa, Peter L. Choyke, Takuya Kato
Publikováno v:
Cancers
Volume 12
Issue 9
Cancers, Vol 12, Iss 2575, p 2575 (2020)
Volume 12
Issue 9
Cancers, Vol 12, Iss 2575, p 2575 (2020)
Simple Summary Near infrared photoimmunotherapy is a newly developed and highly selective cancer treatment that employs a monoclonal antibody conjugated to a photo-absorber dye, IRDye700DX, which is activated by 690 nm light. Cancer cell-targeted nea
Autor:
Tadanobu Nagaya, Hisataka Kobayashi, Shuhei Okuyama, Kazuhide Sato, Fusa Ogata, Peter L. Choyke, Yasuhiro Maruoka
Publikováno v:
Mol Pharm
Near infrared photoimmunotherapy (NIR-PIT) is a new target-cell specific cancer treatment that induces highly selective necrotic/immunogenic cell death after systemic administration of a photoabsorber antibody conjugate and subsequent NIR light expos
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:925-930
Fluorescence-guided imaging during surgery is a promising technique that is increasingly used to aid surgeons in identifying sites of tumor and surgical margins. Of the two types of fluorescent probes, always-on and activatable, activatable probes ar
Autor:
Peter L. Choyke, Shuhei Okuyama, Fusa Ogata, Tadanobu Nagaya, Yuko Nakamura, Yasuhiro Maruoka, Clint T. Allen, Hisataka Kobayashi
Publikováno v:
Molecular Cancer Research. 15:1667-1677
Oral cavity squamous cell carcinoma (OSCC) is considered one of the most aggressive subtypes of cancer. Anti-CD44 monoclonal antibodies (mAb) are a potential therapy against CD44 expressing OSCC; however, to date the therapeutic effects have been dis