Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Ron Stewart"'
Autor:
Finn Kuusisto, Danielle A. Scholze, Arezoo Movaghar, Murray H. Brilliant, Ron Stewart, Leann Smith DaWalt, David C. Page, Marsha R. Mailick, Jinkuk Hong
Publikováno v:
Genetics in Medicine
Purpose Fragile X syndrome (FXS), the most prevalent inherited cause of intellectual disability, remains underdiagnosed in the general population. Clinical studies have shown that individuals with FXS have a complex health profile leading to unique c
Publikováno v:
Cell Reports, Vol 38, Iss 6, Pp 110333-(2022)
Cell Rep
Cell Rep
Summary: Cellular gene expression changes throughout a dynamic biological process, such as differentiation. Pseudotimes estimate cells’ progress along a dynamic process based on their individual gene expression states. Ordering the expression data
Autor:
Brian Johnson, Gregory A. Barrett-Wilt, Srikumar Sengupta, Bret Duffin, Ron Stewart, Hamisha Ardalani, James A. Thomson, Morten Seirup
Publikováno v:
Current Research in Toxicology
Current Research in Toxicology, Vol 1, Iss, Pp 70-84 (2020)
Current Research in Toxicology, Vol 1, Iss, Pp 70-84 (2020)
Derivation and culture of small hepatocyte progenitor cells (SHPCs) capable of proliferating in vitro has been described in rodents and recently in humans. These cells are capable of engrafting in injured livers, however, they display de-differentiat
Autor:
Vanessa Linke, Edna A. Trujillo, Harold A. Singer, Dain R. Brademan, Deane F. Mosher, Laura K. Muehlbauer, Qiuwen Quan, Evgenia Shishkova, Matthew N. Bernstein, Bradford S Schwartz, Ian J. Miller, Ariel Jaitovich, Jesse G. Meyer, Trenton M. Peters-Clarke, Joshua J. Coon, Scott Swanson, Amit Chopra, Hau Chieng, Brett Paulson, Katherine A. Overmyer, Yunyun Zhu, Joseph Balnis, Anupama Tiwari, Yuchen He, Marc A. Judson, Ron Stewart, Lisa A. Drake, Alejandro P. Adam, Lia R. Serrano
Publikováno v:
Cell Systems
Journal of Translational Medicine
medRxiv
article-version (status) pre
article-version (number) 1
Journal of Translational Medicine
medRxiv
article-version (status) pre
article-version (number) 1
We performed RNA-Seq and high-resolution mass spectrometry on 128 blood samples from COVID-19 positive and negative patients with diverse disease severities and outcomes. Quantified transcripts, proteins, metabolites, and lipids were associated with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::590b3e958caa102293bf216fffc2d6d4
https://doi.org/10.1101/2020.07.17.20156513
https://doi.org/10.1101/2020.07.17.20156513
Autor:
Tania Incitti, Fabrizio Rinaldi, James A. Thomson, Radbod Darabi, Ami Yamamoto, Scott Swanson, Ron Stewart, James Kiley, Rita C.R. Perlingeiro, Alessandro Magli, Jakub Tolar, Sridhar Selvaraj, Ce Yuan
Publikováno v:
Cell Reports, Vol 19, Iss 13, Pp 2867-2877 (2017)
Summary Pluripotent stem (PS)-cell-derived cell types hold promise for treating degenerative diseases. However, PS cell differentiation is intrinsically heterogeneous; therefore, clinical translation requires the development of practical methods for
Autor:
Yongsheng Bai, Victor Ruotti, Bao Kim Nguyen, James A. Thomson, Ron Stewart, Zhonggang Hou, Angela L. Elwell, Scott Swanson, William L. Murphy, Michael P. Schwartz, Hamisha Ardalani, John Steill, Jennifer M. Bolin, Jue Zhang
Publikováno v:
Stem Cell Reports, Vol 8, Iss 4, Pp 907-918 (2017)
Stem Cell Reports
Stem Cell Reports
Summary A defined protocol for efficiently deriving endothelial cells from human pluripotent stem cells was established and vascular morphogenesis was used as a model system to understand how synthetic hydrogels influence global biological function c
Autor:
Scott Swanson, Bret Duffin, Michael P. Schwartz, Matthew T. Schmitz, Rhonda Bacher, Jennifer M. Bolin, Brian E. McIntosh, Angela L. Elwell, James A. Thomson, Ron Stewart, Peng Jiang, Christopher Barry
Publikováno v:
Developmental Biology. 423:101-110
How species-specific developmental timing is controlled is largely unknown. By following human embryonic stem (ES) cell and mouse epiblast stem (EpiS) cell differentiation through detailed RNA-sequencing time courses, here we show that pluripotent st
Autor:
Zhaobin Kuang, James A. Thomson, David C. Page, Rebecca Willett, Peggy L. Peissig, Ron Stewart, Michael D. Caldwell, Yujia Bao
Publikováno v:
Methods in Molecular Biology ISBN: 9781493989546
We present the baseline regularization model for computational drug repurposing using electronic health records (EHRs). In EHRs, drug prescriptions of various drugs are recorded throughout time for various patients. In the same time, numeric physical
Autor:
Matthew R. Zanotelli, Lauren L. Bischel, Michael P. Schwartz, Jue Zhang, Angela L. Elwell, Angela W. Xie, Ron Stewart, James A. Thomson, William L. Murphy, David J. Beebe, Hamisha Ardalani, Eric H. Nguyen, Scott Swanson, Zhonggang Hou, Bao Kim Nguyen, Jennifer M. Bolin
Publikováno v:
Acta Biomaterialia. 35:32-41
Here, we describe an in vitro strategy to model vascular morphogenesis where human induced pluripotent stem cell-derived endothelial cells (iPSC-ECs) are encapsulated in peptide-functionalized poly(ethylene glycol) (PEG) hydrogels, either on standard
Autor:
Ning Leng, Audrey P. Gasch, Li-Fang Chu, Michael A. Newton, James A. Thomson, Rhonda Bacher, Christina Kendziorski, Ron Stewart
Publikováno v:
Nature methods
The normalization of RNA-seq data is essential for accurate downstream inference, but the assumptions upon which most normalization methods are based are not applicable in the single-cell setting. Consequently, applying existing normalization methods