Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Philip S. Tsao"'
Autor:
Roshni A. Patel, Shaila A. Musharoff, Jeffrey P. Spence, Harold Pimentel, Catherine Tcheandjieu, Hakhamanesh Mostafavi, Nasa Sinnott-Armstrong, Shoa L. Clarke, Courtney J. Smith, Peter P. Durda, Kent D. Taylor, Russell Tracy, Yongmei Liu, W. Craig Johnson, Francois Aguet, Kristin G. Ardlie, Stacey Gabriel, Josh Smith, Deborah A. Nickerson, Stephen S. Rich, Jerome I. Rotter, Philip S. Tsao, Themistocles L. Assimes, Jonathan K. Pritchard
Publikováno v:
Am J Hum Genet
Despite the growing number of genome-wide association studies (GWASs), it remains unclear to what extent gene-by-gene and gene-by-environment interactions influence complex traits in humans. The magnitude of genetic interactions in complex traits has
Publikováno v:
Vasc Med
Introduction: Peripheral artery disease (PAD) is a major cause of cardiovascular morbidity and mortality, yet timely diagnosis is elusive. Larger genome-wide association studies (GWAS) have now provided the ability to evaluate whether genetic data, i
Autor:
Shoa L. Clarke, Rose D.L. Huang, Austin T. Hilliard, Catherine Tcheandjieu, Julie Lynch, Scott M. Damrauer, Kyong-Mi Chang, Philip S. Tsao, Themistocles L. Assimes
Publikováno v:
Circulation
Autor:
Ian Y. Chen, Vijay Vedula, Sachin B. Malik, Tie Liang, Andrew Y. Chang, Kieran S. Chung, Nazish Sayed, Philip S. Tsao, John C. Giacomini, Alison L. Marsden, Joseph C. Wu
Publikováno v:
Circ Cardiovasc Imaging
Background: Computed tomography–based evaluation of aortic stenosis (AS) by calcium scoring does not consider interleaflet differences in leaflet characteristics. Here, we sought to examine the functional implications of these differences. Methods:
Autor:
Michael G. Levin, Neil M Davies, Julie Lynch, Pradeep Natarajan, Todd L. Edwards, Philip S. Tsao, Daniel J. Rader, Dipender Gill, Benjamin F. Voight, Kyung Min Lee, Derek Klarin, Kyong-Mi Chang, Venexia M Walker, Scott M. Damrauer, Themistocles L. Assimes, Jacklyn N. Hellwege, J. Michael Gaziano, Adriana M. Hung, Jacob M. Keaton
Publikováno v:
Arterioscler Thromb Vasc Biol
Objective: We aimed to estimate the effect of blood pressure (BP) traits and BP-lowering medications (via genetic proxies) on peripheral artery disease. Approach and Results: Genome-wide association studies summary statistics were obtained for BP, pe
Autor:
Sai Zhang, Johnathan Cooper-Knock, Annika K. Weimer, Minyi Shi, Lina Kozhaya, Derya Unutmaz, Calum Harvey, Thomas H. Julian, Simone Furini, Elisa Frullanti, Francesca Fava, Alessandra Renieri, Peng Gao, Xiaotao Shen, Ilia Sarah Timpanaro, Kevin P. Kenna, J. Kenneth Baillie, Mark M. Davis, Philip S. Tsao, Michael P. Snyder
Publikováno v:
medRxiv
Zhang, S, Cooper-Knock, J, Weimer, A K, Shi, M, Kozhaya, L, Unutmaz, D, Harvey, C, Julian, T H, Furini, S, Frullanti, E, Fava, F, Renieri, A, Gao, P, Shen, X, Timpanaro, I S, Kenna, K P, Baillie, J K, Davis, M M, Tsao, P S & Snyder, M P 2022, ' Multiomic analysis reveals cell-type-specific molecular determinants of COVID-19 severity ', Cell Systems, vol. 13, no. 8, pp. 598-614.e6 . https://doi.org/10.1016/j.cels.2022.05.007
Zhang, S, Cooper-Knock, J, Weimer, A K, Shi, M, Kozhaya, L, Unutmaz, D, Harvey, C, Julian, T H, Furini, S, Frullanti, E, Fava, F, Renieri, A, Gao, P, Shen, X, Timpanaro, I S, Kenna, K P, Baillie, J K, Davis, M M, Tsao, P S & Snyder, M P 2022, ' Multiomic analysis reveals cell-type-specific molecular determinants of COVID-19 severity ', Cell Systems, vol. 13, no. 8, pp. 598-614.e6 . https://doi.org/10.1016/j.cels.2022.05.007
The determinants of severe COVID-19 in non-elderly adults are poorly understood, which limits opportunities for early intervention and treatment. Here we present novel machine learning frameworks for identifying common and rare disease-associated gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee53376ea581a5028c54e7186b170fe2
https://eprints.whiterose.ac.uk/189196/1/1-s2.0-S2405471222002289-main.pdf
https://eprints.whiterose.ac.uk/189196/1/1-s2.0-S2405471222002289-main.pdf
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports
Scientific Reports
Biomedical studies have become larger in size and yielded large quantities of data, yet efficient data processing remains a challenge. Here we present Trellis, a cloud-based data and task management framework that completely automates the process fro
Autor:
John Concato, Timothy J. O'Leary, Mary Brophy, Lakshmi Radhakrishnan, Jie Huang, Purushotham Karnam, VA Million Veteran Program, Sun-Gou Ji, Haley Hunter-Zinck, Saiju Pyarajan, Man Li, Yunling Shi, Xin Gong, Jennifer Moser, Ronald M. Przygodzki, Philip S. Tsao, Elizabeth R. Hauser, Sumitra Muralidhar, Joel Gelernter, Paul Hsieh, John Michael Gaziano, Ning Sun, Poornima Devineni, Donald E. Humphries, Christopher J. O'Donnell, Hongyu Zhao, Teresa Webster, Themistocles L. Assimes, Grant D. Huang, Jeanette Schmidt, Andrew Liem, Cuiping Pan, Bryan R Gorman
Publikováno v:
Am J Hum Genet
The Million Veteran Program (MVP), initiated by the Department of Veterans Affairs (VA), aims to collect biosamples with consent from at least one million veterans. Presently, blood samples have been collected from over 800,000 enrolled participants.
Autor:
Saiju Pyarajan, Nicholas L. Smith, Julie Lynch, Sara Lindström, Michael G. Levin, Marijana Vujkovic, Charles Kooperberg, Danish Saleheen, Qing Shao, William E. Boden, Themistocles L. Assimes, Yan V. Sun, Peter D. Reaven, Sekar Kathiresan, Peter W.F. Wilson, Andrea T. Obi, Daniel J. Rader, Scott L. DuVall, David-Alexandre Trégouët, Jeffery Haessler, Pradeep Natarajan, Christopher Kabrhel, Krishna G. Aragam, Emma Busenkell, Renae Judy, Yunfeng Huang, Mary E. Haas, Peter K. Henke, J. Michael Gaziano, Jie Huang, Scott M. Damrauer, Philip S. Tsao, Kyung Min Lee, Donald R. Miller, John Concato, Kyong-Mi Chang, Jennifer E. Huffman, Mark Chaffin, Christopher J. O'Donnell, Alexander P. Reiner, Derek Klarin, Kelly Cho
Publikováno v:
Nature Genetics
Nature Genetics, Nature Publishing Group, 2019, 51 (11), pp.1574-1579. ⟨10.1038/s41588-019-0519-3⟩
Nature genetics
Nature Genetics, Nature Publishing Group, 2019, 51 (11), pp.1574-1579. ⟨10.1038/s41588-019-0519-3⟩
Nature genetics
Venous thromboembolism (VTE) is a significant cause of mortality1, yet its genetic determinants remain incompletely defined. We performed a discovery genome-wide association study in the Million Veteran Program and UK Biobank testing ~13 million DNA
Autor:
Themistocles L. Assimes, P. S. Sriram, Qin Hui, Stephen Mastorides, Zuhair Ballas, Yan V. Sun, Hua Tang, Marijana Vujkovic, Ronald G Washburn, Samuel M. Aguayo, Jennifer Moser, Gwenevere Anderson, Mary A. Whooley, Sumitra Muralidhar, Agnes Wallbom, Adriana M. Hung, Xuan-Mai T. Nguyen, Huaying Fang, Jennifer Greco, Rachel B. Ramoni, Amparo Gutierrez, Saiju Pyarajan, Stuart R. Warren, Rob Striker, Pran Iruvanti, Mark B. Hamner, Scott L. DuVall, Elizabeth R. Hauser, Christopher J. O'Donnell, Donald E. Humphries, Jon B. Klein, Nora R. Ratcliffe, John M. Wells, Maureen Murdoch, Gerardo Villareal, Laurence Kaminsky, Peter W. F. Wilson, Mary E. Oehlert, Mary Brophy, Stacey B. Whitbourne, Louis J. Dell’Italia, Grant D. Huang, Ronald Fernando, Dean P. Argyres, Jie Huang, Hongyu Zhao, Scott Kinlay, Kelly Cho, Jeff Whittle, Scott M. Damrauer, Jacqueline Honerlaw, Sunil K. Ahuja, Laurence Meyer, Brooks Robey, John B. Harley, Gretchen Gibson, John Concato, Rachel McArdle, David Cohen, Krisann K. Oursler, Robin A. Hurley, Sujata Bhushan, Salvador Gutierrez, D Jhala, John J. Callaghan, Ron B. Schifman, Nhan Do, Junzhe Xu, Jim Breeling, Jessica V. Brewer, Elif Sonel, Kyong-Mi Chang, Peter W.F. Wilson, Brady Stephens, Shahpoor Shayan, Philip S. Tsao, Joseph Fayad, Michael Godschalk, Jack H. Lichy, Scott Sherman, Shing Shing Yeh, Alan Swann, Michael Rauchman, Samir Gupta, Satish C. Sharma, Edward Boyko, J. Michael Gaziano, Julie Lynch, Timothy R. Morgan, Jean C. Beckham, Todd Stapley, Malcolm Buford, Richard J. Servatius, Hermes Florez, Kathlyn Sue Haddock
Publikováno v:
The American Journal of Human Genetics. 105:763-772
Large-scale multi-ethnic cohorts offer unprecedented opportunities to elucidate the genetic factors influencing complex traits related to health and disease among minority populations. At the same time, the genetic diversity in these cohorts presents