Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Marcela V Maus"'
Publikováno v:
Science
Immune cells are being engineered to recognize and respond to disease states, acting as a “living drug” when transferred into patients. Therapies based on engineered immune cells are now a clinical reality, with multiple engineered T cell therapi
Autor:
Marcela V, Maus
Publikováno v:
Nature
The adoptive transfer of T lymphocytes reprogrammed to target tumour cells has demonstrated potential for treatment of various cancers(1–7). However, little is known about the long-term potential and clonal stability of the infused cells. Here we s
Autor:
Marcela V. Maus, Rebecca C. Larson
Publikováno v:
Nat Rev Cancer
This Review discusses the major advances and changes made over the past 3 years to our understanding of chimeric antigen receptor (CAR) T cell efficacy and safety. Recently, the field has gained insight into how various molecular modules of the CAR i
Autor:
Stephen M. Pastores, Sattva S. Neelapu, Alice Gallo De Moraes, Elena Mead, Alejandro S. Arias, Cristina Gutierrez, Abhijit Duggal, Joseph L. Nates, Jennifer N. Brudno, Cameron J. Turtle, Sameer S Kadri, Prabalini Rajendram, Marcela V. Maus, Ananda Dharshan, Colleen McEvoy, Heather P. May, Mathew J. Frigault, Nirali N. Shah, Janhavi Athale, Yi Lin, Amer Beitinjaneh, Anne Rain T. Brown, Brian T. Hill, James N. Kochenderfer, Megan M. Herr, R. Scott Stephens, Kevin R. Patel
Publikováno v:
J Crit Care
Purpose A task force of experts from 11 United States (US) centers, sought to describe practices for managing chimeric antigen receptor (CAR) T-cell toxicity in the intensive care unit (ICU). Materials and methods Between June–July 2019, a survey w
Autor:
Marcello Stanzione, Songfa Zhang, Nicholas J. Dyson, John F. Rawls, Eric J Alpert, David Millar, Daniel Do, David M. Langenau, Yun Wei, Benjamin J. Drapkin, Irene Scarfò, John C. Moore, Qian Qin, Alexandra Veloso, Qiqi Yang, Dalton C. Brunson, Karin M. McCarthy, Marcela V. Maus, Chuan Yan, Mark Cobbold, Sowmya Iyer
Publikováno v:
The Journal of Experimental Medicine
Xenograft cancer studies using rag2Δ/Δ, il2rga−/− zebrafish allow facile, single-cell imaging of T cell–mediated tumor killing by CAR T cell, BiTE, and APEC immunotherapies and identified EGFR-targeted immunotherapies as an effective treatmen
Autor:
Gabrielle Brini, Jennifer Y. Yam, Kathleen Gallagher, Katelin Katsis, Rebecca C. Larson, Trisha R. Berger, Mark B. Leick, Marcela V. Maus, Korneel Grauwet
Publikováno v:
bioRxiv
article-version (status) pre
article-version (number) 1
article-version (status) pre
article-version (number) 1
SUMMARYRecently, two mRNA vaccines to severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) have become available, but there is also an emergence of SARS-CoV-2 variants with increased transmissibility and virulence1–6. A major concern is wh
Autor:
Lyh Ping Lam, Sundar Jagannath, Michaela Liedtke, M. Travis Quigley, Jacalyn Rosenblatt, Richard A. Morgan, Fabio Petrocca, Greg Russotti, Monica Massaro, Kevin G. Friedman, Noopur Raje, Kristen Hege, David S. Siegel, James N. Kochenderfer, Deepu Madduri, Jesus G. Berdeja, Yi Lin, Zhihong Yang, Julie Wang, Nikhil C. Munshi, Marcela V. Maus, Ashley Turka, Timothy B. Campbell
Publikováno v:
N Engl J Med
BACKGROUND: Preclinical studies suggest that bb2121, a chimeric antigen receptor (CAR) T-cell therapy that targets B-cell maturation antigen (BCMA), has potential for the treatment of multiple myeloma. METHODS: In this phase 1 study involving patient
Autor:
Ekta Patel, Jessica Gierut, G. Christian Baldeviano, Niko Thorausch, Solly Weiler, Bonnie Le, Janani Krishnamurthy, Jian Ding, Marcela V. Maus, Patrick A. Baeuerle, Robert Hofmeister, Qi Wei, Irene Scarfò, Patrick Tavares, Olga Kiner, Wolfgang W. A. Schamel, Daniel Getts, Justin Quinn, Rashmi Choudhary, Holly Horton, Anna Morath
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications
T cells expressing CD19-targeting chimeric antigen receptors (CARs) reveal high efficacy in the treatment of B cell malignancies. Here, we report that T cell receptor fusion constructs (TRuCs) comprising an antibody-based binding domain fused to T ce
Publikováno v:
Autoimmunity
BACKGROUND AIM: T-Cell immunotherapies are rapidly gaining grounds in clinical success. Presently, there is first-to-market knowledge on the translation of research scale methods to clinical and commercial scales. Improved understanding can lead to m
Publikováno v:
Clinical Cancer Research. 25:2042-2048
Glioblastoma (GBM) is a devastating disease with an extremely poor prognosis. Immunotherapy via adoptive cell transfer (ACT), especially with T cells engineered to express chimeric antigen receptors (CAR), represents a particularly promising approach