Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Mandy L. Ford"'
Autor:
Brendan P. Lovasik, Steven C. Kim, Laura Higginbotham, Walter Wakwe, David V. Mathews, Cynthia Breeden, Alton B. Farris, Christian P. Larsen, Mandy L Ford, Steven Nadler, Andrew B. Adams
Publikováno v:
bioRxiv
Costimulation blockade using belatacept results in improved renal function after kidney transplant as well as decreased likelihood of death/graft loss and reduced cardiovascular risk; however, higher rates and grades of acute rejection have prevented
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aca54b8e26e45704b751f46d9050933b
https://europepmc.org/articles/PMC10187313/
https://europepmc.org/articles/PMC10187313/
Autor:
Mandy L. Ford, Yini Sun, Jennifer M. Robertson, Aneesh K. Mehta, Marvi Tariq, Scott M. Krummey, Christina R. Hartigan, He Sun, Ching wen Chen
Publikováno v:
Am J Transplant
Belatacept confers increased patient and graft survival in renal transplant recipients relative to calcineurin inhibitors, but is associated with an increased rate of acute rejection. Recent immunophenotypic studies comparing pre-transplant T cell ph
Autor:
Danya Liu, Mandy L. Ford
Publikováno v:
Am J Transplant
Antagonism of the CD154/CD40 pathway is a highly effective means of inducing long-term graft survival in pre-clinical models. Using a fully allogeneic murine transplant model, we found that CD154 blockade was more effective in prolonging graft surviv
Publikováno v:
Am J Transplant
CTLA-4Ig (belatacept) blocks the CD80/CD86 ligands for both CD28 and CTLA-4; thus, in addition to the intended effect of blocking CD28-mediated costimulation, belatacept also has the unintended effect of blocking CTLA-4-mediated coinhibition. Recentl
Autor:
Ashley A. Miniet, Eileen M. Burd, Craig M. Coopersmith, Zhe Liang, Yini Sun, Mandy L. Ford, Takehiko Oami
Publikováno v:
Shock
Sepsis-induced intestinal hyperpermeability is mediated by disruption of the epithelial tight junction, which is closely associated with the peri-junctional actin-myosin ring. Genetic deletion of myosin light chain kinase (MLCK) reverses intestinal h
Autor:
Ching-Wen Chen, Craig M. Coopersmith, Mandy L. Ford, Deena B. Chihade, Wenxiao Zhang, Zhe Liang, Alton B. Farris, John D. Lyons, Eileen M. Burd
Publikováno v:
Shock
Patients with cancer who develop sepsis have a markedly higher mortality than patients who were healthy prior to the onset of sepsis. Potential mechanisms underlying this difference have previously been examined in two preclinical models of cancer fo
Autor:
Shunsuke Otani, Rebecca L. Crepeau, Jianfeng Xie, Mandy L. Ford, Ching-Wen Chen, Wenxiao Zhang, Craig M. Coopersmith
Publikováno v:
Journal of Leukocyte Biology. 105:565-575
Epstein–Barr virus (EBV) reactivation commonly occurs following sepsis, but the mechanisms underlying this are unknown. We utilized a murine EBV homolog (gHV) and the cecal ligation and puncture model of polymicrobial sepsis to study the impact of
Autor:
Nathan J. Klingensmith, Ching-Wen Chen, Katherine T. Fay, Mandy L. Ford, Zhe Liang, Mei Meng, Craig M. Coopersmith, John D. Lyons
Publikováno v:
Shock. 51:88-96
The gut is a continuously renewing organ, with cell proliferation, migration and death occurring rapidly under basal conditions. Since the impact of critical illness on cell movement from crypt base to villus tip is poorly understood, the purpose of
Autor:
Elise R. Breed, Eileen M. Burd, Rudolph L. Gleason, Benyam P. Yoseph, Craig M. Coopersmith, Zhe Liang, Carolyn A. Hilliard, Clayton R. Hunt, Ching-Wen Chen, Luke P. Brewster, Laura Hansen, Mandy L. Ford, Rohit Mittal, Tej K. Pandita
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports
Scientific Reports
In vitro studies have implicated the small heat shock protein HSPB1 in a range of physiological functions. However, its in vivo relevance is unclear as the phenotype of unstressed HSPB1−/− mice is unremarkable. To determine the impact of HSPB1 in
Autor:
Glenn Michael La Muraglia, Idelberto R. Badell, Emma S. Crichton, Maylene E. Wagener, Susan Zeng, Mandy L. Ford
Publikováno v:
Am J Transplant
Anti-donor antibodies cause immunologic injury in transplantation. CD28 blockade with CTLA-4-Ig has the ability to reduce the incidence of these donor-specific antibodies (DSA), but its mechanism is suboptimal for the inhibition of alloimmunity in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64f3dc80ed22866d214e692620daa73b
https://europepmc.org/articles/PMC7665991/
https://europepmc.org/articles/PMC7665991/