Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Lige Tonggu"'
Autor:
Régis Pomès, Daohua Jiang, Tamer M. Gamal El-Din, Richard Banh, Lige Tonggu, Ning Zheng, William A. Catterall
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Voltage-gated sodium (NaV) channels initiate action potentials in excitable cells, and their function is altered by potent gating-modifier toxins. The α-toxin LqhIII from the deathstalker scorpion inhibits fast inactivation of cardiac NaV1.5 channel
Autor:
Goragot, Wisedchaisri, Lige, Tonggu, Tamer M, Gamal El-Din, Eedann, McCord, Ning, Zheng, William A, Catterall
Publikováno v:
Mol Cell
Voltage-gated sodium channels initiate electrical signals and are frequently targeted by deadly gating-modifier neurotoxins, including tarantula toxins, which trap the voltage sensor in its resting state. The structural basis for tarantula-toxin acti
Autor:
William A. Catterall, Hui Shi, Yan Zhao, Daohua Jiang, Ning Zheng, Craig Yoshioka, Lige Tonggu, Tamer M. Gamal El-Din, Michael J. Lenaeus
Publikováno v:
Cell
Summary Voltage-gated sodium channel Nav1.5 generates cardiac action potentials and initiates the heartbeat. Here, we report structures of NaV1.5 at 3.2–3.5 A resolution. NaV1.5 is distinguished from other sodium channels by a unique glycosyl moiet
Autor:
Michael J. Lenaeus, Régis Pomès, Tamer M. Gamal El-Din, Ning Zheng, Richard Banh, William A. Catterall, Lige Tonggu, Daohua Jiang
Publikováno v:
Cell
The heartbeat is initiated by voltage-gated sodium channel Na(V)1.5, which opens rapidly and triggers the cardiac action potential; however, the structural basis for pore opening remains unknown. Here we blocked fast inactivation with a mutation and
Autor:
Ning Zheng, Liguo Wang, E. McCord, Lige Tonggu, Goragot Wisedchaisri, Tamer M. Gamal El-Din, William A. Catterall
Publikováno v:
Cell
Trends Pharmacol Sci
Trends Pharmacol Sci
Voltage-gated sodium (Na(V)) channels initiate action potentials in nerve, muscle, and other electrically excitable cells. The structural basis of voltage gating is uncertain because the resting state exists only at deeply negative membrane potential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98813f6f11e0436ef277afe32b177c3b
https://europepmc.org/articles/PMC6688928/
https://europepmc.org/articles/PMC6688928/
Autor:
Liguo Wang, Lige Tonggu
Publikováno v:
Ultramicroscopy
Liposomes are widely used as delivery systems in pharmaceutical, cosmetics and food industries, as well as a system for structural and functional study of membrane proteins. To accurately characterize liposomes, cryo-Electron Microscopy (cryo-EM) has
Autor:
Cui Huang, Liguo Wang, Si Ying Liu, Bing Fan, David H. Pashley, Franklin R. Tay, Shiqiang Gong, Li Na Niu, Lige Tonggu, Ji Hong Zhao
Publikováno v:
Scientific Reports
Quaternary ammonium methacryloxy silicate (QAMS)-containing acrylic resin demonstrated contact-killing antimicrobial ability in vitro after three months of water storage. The objective of the present double-blind randomised clinical trial was to dete
Autor:
Ji Hong Bian, Mo Li, Sang Eun Jee, Lorenzo Breschi, Franklin R. Tay, Li Na Niu, Ji Hua Chen, Yao Dong Yang, Lige Tonggu, Liguo Wang, Seung Soon Jang, Kai Jiao, David H. Pashley
Publikováno v:
Nature materials
Mineralisation of fibrillar collagen with biomimetic process-directing agents has enabled scientists to gain insight into the potential mechanisms involved in intrafibrillar mineralisation. Here, by using polycation- and polyanion-directed intrafibri