Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Koichi Araki"'
Autor:
Masao, Hashimoto, Koichi, Araki, Maria A, Cardenas, Peng, Li, Rohit R, Jadhav, Haydn T, Kissick, William H, Hudson, Donald J, McGuire, Rebecca C, Obeng, Andreas, Wieland, Judong, Lee, Daniel T, McManus, James L, Ross, Se Jin, Im, Junghwa, Lee, Jian-Xin, Lin, Bin, Hu, Erin E, West, Christopher D, Scharer, Gordon J, Freeman, Arlene H, Sharpe, Suresh S, Ramalingam, Alex, Pellerin, Volker, Teichgräber, William J, Greenleaf, Christian, Klein, Jorg J, Goronzy, Pablo, Umaña, Warren J, Leonard, Kendall A, Smith, Rafi, Ahmed
Publikováno v:
Nature
Combination therapy with PD-1 blockade and IL-2 is highly effective during chronic lymphocytic choriomeningitis virus infection(1). Here we examine the underlying basis for this synergy. We show that PD-1 + IL-2 combination therapy, unlike PD-1 monot
Autor:
Scott M. Krummey, Koichi Araki, Satomi Ando, Sara A. Guasch, Anna B. Morris, Weiwen Zhang, Christian P. Larsen, Jennifer Robertson, Katherine P. Tong, Jesica R. Jacobs, Brian D. Evavold, Haydn T. Kissick, Donald J. McGuire, Mandy L. Ford
Publikováno v:
Cell Reports, Vol 30, Iss 5, Pp 1282-1291.e5 (2020)
Summary: The identity of CD45 isoforms on the T cell surface changes following the activation of naive T cells and impacts intracellular signaling. In this study, we find that the anti-viral memory CD8+ T pool is unexpectedly comprised of both CD45RB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d1a6679e5fdaa0a65446604cd08445
https://europepmc.org/articles/PMC7155808/
https://europepmc.org/articles/PMC7155808/
Autor:
Haydn T. Kissick, Xiaodong Cheng, Eunseon Ahn, Erin E. West, Xiaojin Xu, Andreas Wieland, Rustom Antia, Ben Youngblood, Rafi Ahmed, Bogumila T. Konieczny, Carl W. Davis, Koichi Araki, Yiping Fan, Pranay Dogra, Hazem E. Ghoneim, J. Scott Hale
Publikováno v:
Nature
Memory CD8 T cells that circulate in the blood and are present in lymphoid organs are an essential component of long-lived T cell immunity. These memory CD8 T cells remain poised to rapidly elaborate effector functions upon re-exposure to pathogens,
Publikováno v:
Vaccine. 33:B21-B28
Engagement of CD8 T cells is a crucial aspect of immune responses to pathogens and in tumor surveillance. Nonetheless most vaccination strategies with common adjuvants fail to elicit long-term memory CD8 T cells. Increased knowledge on the cellular a
Autor:
Pablo Penaloza-MacMaster, Shu Yang, Erin E. West, Andreas Wieland, Koichi Araki, Smita S. Iyer, Bogumila T. Konieczny, Gordon J. Freeman, Leigh A. O’Mara, Alexander Y. Rudensky, Rafi Ahmed, Alice O. Kamphorst, Arlene H. Sharpe
Publikováno v:
The Journal of Experimental Medicine
T reg cells effectively maintain CD8 T cell exhaustion during chronic LCMV infection, but blockade of PD-1 is critical for elimination of infected cells.
Regulatory T (T reg) cells are critical for preventing autoimmunity mediated by self-reacti
Regulatory T (T reg) cells are critical for preventing autoimmunity mediated by self-reacti
Publikováno v:
Current Opinion in Cell Biology. 23:707-715
The target of rapamycin (TOR) is a critical intracellular regulator of the immune system. Recent studies have suggested that immunosuppression by TOR inhibition may be mediated by modulating differentiation of both effector and regulatory CD4 T cell
Autor:
Rafi Ahmed, Bogumila T. Konieczny, W. Nicholas Haining, Wendy G. Tan, Gordon J. Freeman, Silvia Calpe, Cox Terhorst, Benjamin Youngblood, Erin E. West, Koichi Araki, Gabriela Alexe, Hyun-Tak Jin
Publikováno v:
Immunity. 35:285-298
To design successful vaccines for chronic diseases, an understanding of memory CD8+ T cell responses to persistent antigen re-stimulation is critical. However, most studies comparing memory and naïve cell responses have only been performed in rapidl
Autor:
Gordon J. Freeman, Chris C. Ibegbu, Satish Gupta, Gregory H. Doho, Bali Pulendran, Pramila Tata, Koichi Araki, Helder I. Nakaya, Michael J. Zilliox, Joseph D. Miller, W. Nicholas Haining, Rafi Ahmed, David Masopust, Jaikumar Duraiswamy
Publikováno v:
The Journal of Immunology. 186:4200-4212
T cell dysfunction is an important feature of many chronic viral infections. In particular, it was shown that programmed death-1 (PD-1) regulates T cell dysfunction during chronic lymphocytic choriomeningitis virus infection in mice, and PD-1hi cells
Publikováno v:
Immunity
Immunity; Vol 33
Immunity; Vol 33
Vaccines work by eliciting an immune response and consequent immunological memory that mediates protection from infection or disease. Recently, new methods have been developed to dissect the immune response in experimental animals and humans, which h
Publikováno v:
Seminars in immunology. 24(6)
mTOR is an evolutionarily conserved serine/threonine kinase that plays a critical role in cell growth and metabolism by sensing different environmental cues. There is a growing appreciation of mTOR in immunology for its role in integrating diverse si