Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Kenneth Y. Kwan"'
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications
The brain is a genomic mosaic shaped by cellular responses to genome damage. Here, we manipulate somatic genome stability by conditional Knl1 deletion from embryonic mouse brain. KNL1 mutations cause microcephaly and KNL1 mediates the spindle assembl
Autor:
Yaman Qalieh, Nitesh Mohan, Owen H. Funk, Adel Qalieh, Kenneth Y. Kwan, Daniel Z. Doyle, Lei Shi, Jason M. Keil, Mandy M. Lam, Alice Sorel
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Chromatin regulates spatiotemporal gene expression during neurodevelopment, but it also mediates DNA damage repair essential to proliferating neural progenitor cells (NPCs). Here, we uncover molecularly dissociable roles for nucleosome remodeler Ino8
Autor:
Lei Gu, Aimee I. Badeaux, Maureen A. Sartor, Chinfei Chen, Andrew Thompson, Emily Brookes, Grace Lin, Giulio Srubek Tomassy, Christina N Vallianatos, Shigeki Iwase, Hikaru Ito, Kenneth Y. Kwan, Saurabh Agarwal, Brian Egan, Yang Shi, Tomas Kasza, Jun Xu
Publikováno v:
Cell Reports, Vol 14, Iss 5, Pp 1000-1009 (2016)
Summary: Mutations in a number of chromatin modifiers are associated with human neurological disorders. KDM5C, a histone H3 lysine 4 di- and tri-methyl (H3K4me2/3)-specific demethylase, is frequently mutated in X-linked intellectual disability (XLID)
Autor:
Ahmed Fatmi, Pierre L. Roubertoux, Joris Andrieux, Catherine Vincent-Delorme, Michèle Carlier, Paolo Gubellini, Laurence Had-Aissouni, Fatimetou Abderrehamane, Bénédicte Duban, Agne Liedén, Detlef Bockenhauer, Emeric Dubois, Mehdi Metwaly, Adrian S. Woolf, Nenad Sestan, Dany Severac, Jean Marie Cuisset, Laurent Fasano, Jean François Lemaitre, Marwan Shinawi, Marie Pierre Lemaitre, Lydia Kerkerian-Le Goff, Eva Rudd, Xavier Caubit, Pascal Salin, Bernard Jacq, Alistair N. Garratt, Kenneth Y. Kwan, Ying Zhu
Publikováno v:
Nature Genetics
Nature Genetics, Nature Publishing Group, 2016, 48 (11), pp.1359-1369. ⟨10.1038/ng.3681⟩
Nature Genetics, 2016, 48 (11), pp.1359-1369. ⟨10.1038/ng.3681⟩
Nature genetics
Caubit, X, Gubellini, P, Andrieux, J, Roubertoux, P L, Metwaly, M, Jacq, B, Fatmi, A, Had-Aissouni, L, Kwan, K Y, Salin, P, Carlier, M, Liedén, A, Rudd, E, Shinawi, M, Vincent-Delorme, C, Cuisset, J-M, Lemaitre, M-P, Fatimetou, A, Duban, B, Lemaitre, J-F, Woolf, A S, Bockenhauer, D, Severac, D, Dubois, E, Zhu, Y, Sestan, N, Garratt, A N, Kerkerian-Le Goff, L & Fasano, L 2016, ' TSHZ3 deletion causes an autism syndrome and defects in cortical projection neurons ', Nature Genetics, vol. 48, pp. 1359-1369 . https://doi.org/10.1038/ng.3681
Nature Genetics, Nature Publishing Group, 2016, 48 (11), pp.1359-1369. ⟨10.1038/ng.3681⟩
Nature Genetics, 2016, 48 (11), pp.1359-1369. ⟨10.1038/ng.3681⟩
Nature genetics
Caubit, X, Gubellini, P, Andrieux, J, Roubertoux, P L, Metwaly, M, Jacq, B, Fatmi, A, Had-Aissouni, L, Kwan, K Y, Salin, P, Carlier, M, Liedén, A, Rudd, E, Shinawi, M, Vincent-Delorme, C, Cuisset, J-M, Lemaitre, M-P, Fatimetou, A, Duban, B, Lemaitre, J-F, Woolf, A S, Bockenhauer, D, Severac, D, Dubois, E, Zhu, Y, Sestan, N, Garratt, A N, Kerkerian-Le Goff, L & Fasano, L 2016, ' TSHZ3 deletion causes an autism syndrome and defects in cortical projection neurons ', Nature Genetics, vol. 48, pp. 1359-1369 . https://doi.org/10.1038/ng.3681
International audience; TSHZ3, which encodes a zinc-finger transcription factor, was recently positioned as a hub gene in a module of the genes with the highest expression in the developing human neocortex, but its functions remained unknown. Here we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1526d52f0caf1ad65c8793faee92cf7
https://hal.archives-ouvertes.fr/hal-01432295
https://hal.archives-ouvertes.fr/hal-01432295
Publikováno v:
Nature
The co-emergence of a six-layered cerebral neocortex and its corticospinal output system is one of the evolutionary hallmarks of mammals. However, the genetic programs that underlie their development and evolution remain poorly understood. Here we id
Autor:
Miloš Judaš, Ben A. Oostra, David H. Rowitch, Mihovil Pletikos, Jie Guang Chen, Kenneth Y. Kwan, Pasko Rakic, Rob Willemsen, Marija Heffer, Lana Vasung, Daniel W. Chan, Eric J. Huang, Nenad Sestan, Ivica Kostović, Mandy M. Lam, Michael L. Schwartz, Sungbo Shim, André M. M. Sousa, Jon I. Arellano, Mladen-Roko Rasin, Sofia Fertuzinhos, Matthew B. Johnson, Umber Dube
Publikováno v:
Cell, 149(4), 899-911. Cell Press
Fragile X syndrome (FXS), the leading monogenic cause of intellectual disability and autism, results from loss of function of the RNA-binding protein FMRP. Here we show that FMRP regulates the translation of neuronal nitric oxide synthase 1 (NOS1) in
Autor:
Kenneth Y. Kwan, Owen H. Funk
Publikováno v:
Neuroscience research. 86
The neocortex underlies not only remarkable motor and sensory capabilities, but also some of our most distinctly human cognitive functions. The emergence of these higher functions during evolution was accompanied by structural changes in the neocorte
Autor:
Kenneth Y. Kwan
Autism spectrum disorders (ASD) impair social cognition and communication, key higher order functions centered in the human neocortex. The assembly of neocortical circuitry is a precisely regulated developmental process susceptible to genetic alterat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c26fdae26eb13c0d1ca3b22a7dde3b6d
https://europepmc.org/articles/PMC4106301/
https://europepmc.org/articles/PMC4106301/
Autor:
Tanyeri Barak, Richard P. Lifton, Ying Zhu, Alp Dinçer, Hande Kaymakçalan, Ali K. Ozturk, Ergin Atalar, Katja Doerschner, Kaya Bilguvar, Murat Gunel, Cengiz Yalcinkaya, Tayfun Ozcelik, Katsuhito Yasuno, Shrikant Mane, Mehmet Bakırcıoğlu, Huseyin Boyaci, Nenad Sestan, Angeliki Louvi, Richard A. Bronen, Ahmet Okay Caglayan, Murim Choi, Kenneth Y. Kwan, Veysi Demirbilek, Beyhan Tüysüz, Serap Saygi, Saliha Yilmaz, William J Brunken
Publikováno v:
Nature Genetics
Cataloged from PDF version of article. The biological basis for regional and inter-species differences in cerebral cortical morphology is poorly understood. We focused on consanguineous Turkish families with a single affected member with complex bila
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b195428b17fbe90cfd02096177d9995
https://hdl.handle.net/11693/21906
https://hdl.handle.net/11693/21906