Zobrazeno 1 - 10
of 98
pro vyhledávání: '"Jianrong Wu"'
Autor:
Li Yao, Jianrong Wu, Weijuan Zou, Zheying Meng, Yuanyi Zheng, Bing Hu, Gareth R. Williams, Xiaojun Cai, Yu Chen
Publikováno v:
Bioactive Materials
Bioactive Materials, Vol 10, Iss, Pp 295-305 (2022)
Bioactive Materials, Vol 10, Iss, Pp 295-305 (2022)
The overexpression of heat shock proteins (HSPs) in tumor cells can activate inherent defense mechanisms during hyperthermia-based treatments, inducing thermoresistance and thus diminishing the treatment efficacy. Here, we report a distinct “non-in
Autor:
Wei Zhang, Weiduo Hou, Yuanyi Zheng, Jianrong Wu, Xue Xie, Chenyi Ye, Wei Gao, Kai Zhang, Mo Chen, Xiaojun Cai
Publikováno v:
Bioactive Materials, Vol 6, Iss 8, Pp 2439-2451 (2021)
Bioactive Materials
Bioactive Materials
Osteoarthritis (OA) is the main cause of disability in the elderly. Effective intervention in the early and middle stage of osteoarthritis can greatly prevent or slow down the development of the disease, and reduce the probability of joint replacemen
Publikováno v:
Pharm Stat
For the cancer clinical trials with immunotherapy and molecularly targeted therapy, time-to-event endpoint is often a desired endpoint. In this paper, we present an event-driven approach for Bayesian one-stage and two-stage single-arm phase II trial
Autor:
Vinay M. Daryani, Andrew M. Davidoff, Wayne L. Furman, Jianrong Wu, Clinton F. Stewart, Sara M. Federico, Alberto S. Pappo, Kenneth J. Caldwell, Mary Beth McCarville, Victor M. Santana, Fariba Navid, Shenghua Mao
Publikováno v:
Eur J Cancer
Background Angiogenesis is critical for tumour growth and metastasis. Dual inhibition of vascular endothelial growth factors and platelet-derived growth factor receptors suppresses angiogenesis. This expansion cohort of a phase I study targeted angio
Autor:
M. Beth McCarville, Alberto S. Pappo, Kirsten K. Ness, Christopher L. Tinkle, Matthew J. Krasin, Barry L. Shulkin, Jianrong Wu, Thomas E. Merchant, Chia-Ho Hua, Armita Bahrami, Sue C. Kaste, Sheri L. Spunt, Shenghua Mao, Andrew M. Davidoff, Daniel M. Green
Publikováno v:
Int J Radiat Oncol Biol Phys
PURPOSE: Our purpose was to assess disease outcomes and late toxicities in pediatric patients with rhabdomyosarcoma treated with conformal photon radiation therapy (RT). METHODS AND MATERIALS: Sixty-eight patients (median age, 6.9 years) were treated
Autor:
Xue Ding, Jianrong Wu
Publikováno v:
Pharm Stat
The indirect mechanism of action of immunotherapy causes a delayed treatment effect, producing delayed separation of survival curves between the treatment groups, and violates the proportional hazards assumption. Therefore using the log-rank test in
Autor:
Jianrong Wu, Jing Wei
Publikováno v:
Stat Med
Cancer immunotherapy trials have two special features: a delayed treatment effect and a cure rate. Both features violate the proportional hazards model assumption and ignoring either one of the two features in an immunotherapy trial design will resul
Publikováno v:
Pharm Stat
Recently molecularly targeted agents and immunotherapy have been advanced for the treatment of relapse or refractory cancer patients, where disease progression-free survival or event-free survival is often a primary endpoint for the trial design. How
Autor:
Jing Wei, Jianrong Wu
Publikováno v:
Pharm Stat
A challenge arising in cancer immunotherapy trial design is the presence of a delayed treatment effect wherein the proportional hazard assumption no longer holds true. As a result, a traditional survival trial design based on the standard log-rank te
Autor:
Jianrong Wu, Yimei Li
Publikováno v:
J Biopharm Stat
Group sequential designs using Lan-DeMets error spending functions are proposed for historical control trials with time-to-event endpoints. Both O’Brien-Fleming and Gamma family types of sequential decision boundaries are derived based on sequentia