Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Francis K. Yoshimoto"'
Autor:
Kaitlyn Varela, Hafij Al Mahmud, Hadi D. Arman, Luis R. Martinez, Catherine A. Wakeman, Francis K. Yoshimoto
Publikováno v:
J Nat Prod
Dihydroartemisinic acid (DHAA) is a plant natural product that undergoes a spontaneous endoperoxide-forming cascade reaction to yield artemisinin in the presence of air. The endoperoxide functional group gives artemisinin its biological activity that
Publikováno v:
The Protein Journal
Coronavirus disease 2019 (COVID-19), which is the pandemic caused by the virus, severe acute respiratory syndrome coronavirus-2 (SARS CoV-2), first appearing in December 2019, continues to confound the world. In this update we provide insights into h
Autor:
Francis K. Yoshimoto
Publikováno v:
The Protein Journal
The global pandemic that shut down the world in 2020 was caused by the virus, SARS CoV-2. The chemistry of the various nonstructural proteins (NSP3, NSP5, NSP12, NSP13, NSP14, NSP15, NSP16) of SARS CoV-2 is discussed. Secondly, a recent major focus o
Autor:
Tapiwa Chiura, Ian Davis, Zehava Eichenbaum, Aimin Liu, Jiafeng Geng, Piotr J. Mak, Ankita J Sachla, Francis K. Yoshimoto, Jiasong Li, Ephrahime S Traore
Publikováno v:
Molecules, Vol 26, Iss 549, p 549 (2021)
Molecules
Volume 26
Issue 3
Molecules
Volume 26
Issue 3
HupZ is an expected heme degrading enzyme in the heme acquisition and utilization pathway in Group A Streptococcus. The isolated HupZ protein containing a C-terminal V5-His6 tag exhibits a weak heme degradation activity. Here, we revisited and charac
Publikováno v:
The Protein Journal
Publikováno v:
Journal of Natural Products
Dihydroartemisinic acid is the biosynthetic precursor to artemisinin, the endoperoxide-containing natural product used to treat malaria. The conversion of dihydroartemisinic acid to artemisinin is a cascade reaction that involves C–C bond cleavage,
Publikováno v:
Chemical Reviews. 118:6573-6655
Many oxidation-reduction (redox) enzymes, particularly oxygenases, have roles in reactions that make and break C-C bonds. The list includes cytochrome P450 and other heme-based monooxygenases, heme-based dioxygenases, non-heme iron mono- and dioxygen
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 161:13-23
All cytochrome P450 enzyme reactions involve a catalytic cycle with several discreet physical or chemical steps. This cycle ends with the formation of the reactive heme iron-oxygen complex, which oxygenates substrate. While the steps might be very si
Autor:
Samuel D. Offei, Mirza Oais Baig, Lazaro S. Chavez, Hadi D. Arman, Francis K. Yoshimoto, Carlos A. Paladini
Publikováno v:
Steroids. 140
Cholic acid is the endogenous 12α-hydroxylated bile acid, which possesses enhanced cholesterol absorption properties compared to its 12-desoxy counterpart, chenodeoxycholic acid. The oxysterol 12α-hydroxylase enzyme is cytochrome P450 8B1 (P450 8B1
Autor:
Jef K. De Brabander, Vincent M. Lynch, Francis K. Yoshimoto, Christopher L. Paradise, Christopher F. Bender
We describe a complete account of our total synthesis and biological evaluation of (-)-berkelic acid and analogs. We delineate a synthetic strategy inspired by a potentially biomimetic union between the natural products spicifernin and pulvilloric ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27220cdcea759ae60ce9a1c1a214c026
https://europepmc.org/articles/PMC5983035/
https://europepmc.org/articles/PMC5983035/