Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Dipanjan Chowdhury"'
Autor:
Rui Zhou, Michelle L. Swift, Aleem Syed, Kaimeng Huang, Lisa Moreau, John A. Tainer, Panagiotis A. Konstantinopoulos, Alan D. D’Andrea, Yizhou Joseph He, Dipanjan Chowdhury
Publikováno v:
bioRxiv
Extent and efficacy of DNA end resection at DNA double strand break (DSB)s determines the choice of repair pathway. Here we describe how the 53BP1 associated protein DYNLL1 works in tandem with Shieldin and the CST complex to protect DNA ends. DYNLL1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d0a3f67fee7a6bd797dce5775b4d0be
https://doi.org/10.1101/2023.03.27.534416
https://doi.org/10.1101/2023.03.27.534416
Autor:
Panagiotis A. Konstantinopoulos, Su-Chun Cheng, Jeffrey G. Supko, Madeline Polak, Andrea E. Wahner-Hendrickson, S. Percy Ivy, Brittany Bowes, Hannah Sawyer, Patrice Basada, Martin Hayes, Jennifer Curtis, Neil Horowitz, Alexi A. Wright, Susana M. Campos, Elena V. Ivanova, Cloud P. Paweletz, Sangeetha Palakurthi, Joyce F. Liu, Alan D. D’Andrea, Prafulla C. Gokhale, Dipanjan Chowdhury, Ursula A. Matulonis, Geoffrey I. Shapiro
Publikováno v:
Br J Cancer
PURPOSE: PARP inhibitor resistance may be overcome by combinatorial strategies with agents that disrupt homologous recombination repair (HRR). Multiple HRR pathway components are HSP90 clients, so that HSP90 inhibition leads to abrogation of HRR and
Autor:
Teresa Cheng, Brooke E. Howitt, Dipanjan Chowdhury, Martin T. King, Ursula A. Matulonis, Panagiotis A. Konstantinopoulos, Wojciech Fendler, Konrad Stawiski, Larissa J. Lee
Publikováno v:
Gynecol Oncol
Objective Uterine serous carcinoma (USC) is an aggressive subtype of endometrial cancer associated with worse survival outcomes in African American (AA) patients. This study evaluated tumor miRNA expression by race, clinical and tumor characteristics
Autor:
Ira Winer, Andrea E. Wahner Hendrickson, Roxanne Quinn, Russell J. Schilder, Alan D. D'Andrea, Alexander B. Olawaiye, Elise C. Kohn, Susan Schumer, Su Chun Cheng, Lisa Barroilhet, Ursula A. Matulonis, Anniina Färkkilä, Michael T. McHale, Dipanjan Chowdhury, Elizabeth K. Lee, L. Austin Doyle, Linda R. Duska, Jennifer Curtis, Siqing Fu, Brittany Bowes, Geoffrey I. Shapiro, Marta A. Crispens, Panagiotis A. Konstantinopoulos, Richard T. Penson
Publikováno v:
Lancet Oncol
Summary Background High-grade serous ovarian cancers show increased replication stress, rendering cells vulnerable to ATR inhibition because of near universal loss of the G1/S checkpoint (through deleterious TP53 mutations), premature S phase entry (
Autor:
Yinghui Zhou, Bose Kochupurakkal, Anniina Färkkilä, Dipanjan Chowdhury, Bruce J. Dezube, Geoffrey I. Shapiro, Huy V. Nguyen, Scott J. Rodig, Alan D. D'Andrea, Pamela N. Munster, Ursula A. Matulonis, Connor A. Jacobson, Sandro Santagata, Yu-An Chen, Ana Lako, Clarence Yapp, Panagiotis A. Konstantinopoulos, Zoltan Maliga, Elizabeth M. Swisher, Doga Gulhan, Julie R. Graham, Denis Schapiro, Elizabeth P. Garcia, Peter J. Park, Julia Casado, Sampsa Hautaniemi, Peter K. Sorger
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Nature Communications
Nature Communications
Combined PARP and immune checkpoint inhibition has yielded encouraging results in ovarian cancer, but predictive biomarkers are lacking. We performed immunogenomic profiling and highly multiplexed single-cell imaging on tumor samples from patients en
Autor:
Connor Clairmont, Alan D. D'Andrea, Guillaume Adelmant, Dipanjan Chowdhury, Jarrod A. Marto, Karthikeyan Ponnienselvan, Lucas D. Galli, Prabha Sarangi, Lisa A. Moreau, Isabelle Csete
Publikováno v:
Proc Natl Acad Sci U S A
Nat Cell Biol
Nat Cell Biol
DNA double-strand breaks (DSBs) are repaired through homology-directed repair (HDR) or non-homologous end joining (NHEJ). BRCA1/2-deficient cancer cells cannot perform HDR, conferring sensitivity to poly(ADP-ribose) polymerase inhibitors (PARPi). How
Autor:
Madeline Polak, Joyce F. Liu, Andrea E. Wahner Hendrickson, Elise C. Kohn, Ursula A. Matulonis, Geoffrey I. Shapiro, Panagiotis A. Konstantinopoulos, Nabihah Tayob, Bose Kochupurakkal, Alan D. D'Andrea, Elizabeth K. Lee, Su Chun Cheng, Doga Gulhan, David L. Kolin, Anniina Färkkilä, Dipanjan Chowdhury, Elizabeth H. Stover, Jennifer Curtis, Alexandre André B.A. da Costa
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
In a trial of patients with high grade serous ovarian cancer (HGSOC), addition of the ATR inhibitor berzosertib to gemcitabine improved progression free survival (PFS) compared to gemcitabine alone but biomarkers predictive of treatment are lacking.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57fc5f0b6a3806ed3027197865ef213b
http://hdl.handle.net/10138/336193
http://hdl.handle.net/10138/336193
Autor:
Guillaume Adelmant, Kavita Shah, Peter Sicinski, Shakti Ranjan Satapathy, Sanket S. Acharya, Dipanjan Chowdhury, Keith Viccaro, Kumar Nikhil, Katherine N. Choe, Amarnath Natarajan, Sandeep Rana, Xiaofeng Zheng, Jarrod A. Marto, Samanta Sharma
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
Mitotic cells attenuate the DNA damage response (DDR) by phosphorylating 53BP1, a critical DDR mediator, to prevent its localization to damaged chromatin. Timely dephosphorylation of 53BP1 is critical for genome integrity, as premature recruitment of
Autor:
Gaofeng Cui, Veronica Rendo, Huy V. Nguyen, Nishita Parnandi, Dipanjan Chowdhury, Rameen Beroukhim, Pascal Drané, Georges Mer, Matthias Altmeyer, Maria Victoria Botuyan, Michaela Remisova
Publikováno v:
Mol Cell
53BP1 influences genome stability via two independent mechanisms: (1) regulating DNA double-strand break (DSB) repair and (2) enhancing p53 activity. We discovered a protein, Tudor-interacting repair regulator (TIRR), that associates with the 53BP1 T
Autor:
Pol Margalef, Anthony J. Cesare, Valerie Borel, Panagiotis Kotsantis, Dipanjan Chowdhury, Ambrosius P. Snijders, Grzegorz Sarek, Helen R. Flynn, David Van Ly, Phil Ruis, Simon J. Boulton, Xiaofeng Zheng
Publikováno v:
Nature
The protection of telomere ends by the shelterin complex prevents DNA damage signalling and promiscuous repair at chromosome ends. Evidence suggests that the 3′ single-stranded telomere end can assemble into a lasso-like t-loop configuration1,2, wh