Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Denise Giuvelis"'
Autor:
Jung-Jin Lee, Francesca Asmus, Kylee Harrington, Rebecca Brackin, Ravin Davis, Jacob Liff, Kyle Bittinger, Bahman Rostama, Glenn W. Stevenson, Anyssa Fisher, Sarah Couture, Meghan May, Denise Giuvelis, Philomena Richard, Sebastien Sannajust, Tamara King, Emily Payne, Elizabeth Mutina, Lisa M. Mattei, Elliot S. Friedman
Publikováno v:
J Pain
The present experiments determined the effects of the narrow-spectrum antibiotic vancomycin on inflammatory pain-stimulated and pain-depressed behaviors in rats. Persistent inflammatory pain was modeled using dilute formalin (0.5%). Two weeks of oral
Autor:
Winston Tan, Joseph Santos-Sacchi, Denise Giuvelis, Edward J. Bilsky, Barbara E. Ehrlich, Luca G. Nolte, Lien D. Nguyen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Scientific Reports
Scientific Reports
Neuronal calcium sensor 1 (NCS1) regulates a wide range of cellular functions throughout the mammalian nervous systems. Altered NCS1 expression is associated with neurodevelopmental and neurodegenerative diseases. Previous studies focused on affectiv
Autor:
Jacob T. Beckley, Xiang Zhou, John C. Hunter, Dennis Monteleone, Anton Delwig, David C. Yeomans, Hassan Pajouhesh, George Luu, John Mulcahy, Denise Giuvelis, Sheri Klas, Ian D Meng
Publikováno v:
Pain
The voltage-gated sodium channel Nav1.7 is highly expressed in nociceptive afferents and is critically involved in pain signal transmission. Nav1.7 is a genetically validated pain target in humans because loss-of-function mutations cause congenital i
Autor:
Katherine Cone, Edward J. Bilsky, Glenn W. Stevenson, Denise Giuvelis, Lajos Szabo, Phillip Atherton, Jean M. Bidlack, Brooke St. Laurent, Julio Dutra, Robin Polt, Rebecca Krivitsky, James Cormier, Emily Warner
Publikováno v:
Psychopharmacology (Berl)
RATIONALE AND OBJECTIVES: The present study characterized the behavioral pharmacology of a novel, mixed-action delta-selective (78:1) opioid receptor agonist, BBI-11008. This glycopeptide drug candidate was tested in assays assessing antinociception
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd9f9facb07f765ae59c8e7f9dffcfd
https://europepmc.org/articles/PMC8106974/
https://europepmc.org/articles/PMC8106974/
Autor:
Jean M. Bidlack, Robin Polt, Edward J. Bilsky, Denise Giuvelis, Yingxue Li, Bobbi Anglin, Dhanasekaran Muthu, Brian I. Knapp, Lindsay St. Louis
Publikováno v:
Journal of Medicinal Chemistry
Glycosylated β-endorphin analogues of various amphipathicity were studied in vitro and in vivo in mice. Opioid binding affinities of the O-linked glycopeptides (mono- or disaccharides) and unglycosylated peptide controls were measured in human recep
Autor:
Denise Giuvelis, Surendra K. Saini, Nicholas McGlinchey, Richard B. Rothman, Edward J. Bilsky, Christina M. Dersch, Subramaniam Ananthan, Heng Xu
Publikováno v:
Journal of medicinal chemistry. 55(19)
In the search for opioid ligands with mixed functional activity, a series of 5'-(4-chlorophenyl)-4,5α-epoxypyridomorphinans possessing alkoxy or acyloxy groups at C-14 was synthesized and evaluated. In this series, the affinity and functional activi
The current study assessed the in vivo antagonist properties of nalmefene using procedures previously used to characterize the opioid antagonists naloxone, naltrexone, 6beta-naltrexol and nalbuphine.ICR mice were used to generate antagonist dose-resp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb7987bfb70cacba400cec2ef01383f
https://europepmc.org/articles/PMC2848904/
https://europepmc.org/articles/PMC2848904/