Zobrazeno 1 - 10
of 38
pro vyhledávání: '"David A Hildeman"'
Autor:
Alyssa L. Thomas, Joseph A. Wayman, Maha Almanan, Anthony T. Bejjani, Emily R. Miraldi, Claire A. Chougnet, David A. Hildeman
Publikováno v:
bioRxiv
Our recent data showed that an aberrant IL-10-producing T follicular helper population (Tfh10) accumulates dramatically with age and is associated with age-related declines in vaccine responsiveness. Through single cell gene expression and chromatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b63aac0794b3d10f53bf2910a107f343
https://doi.org/10.1101/2023.03.17.533214
https://doi.org/10.1101/2023.03.17.533214
Autor:
Sharmila Shanmuganad, Autumn Ferguson, Aditi Paranjpe, Eileen Elfers Cianciolo, Jonathan D. Katz, Marco J Herold, David A. Hildeman
Publikováno v:
bioRxiv
Following their proliferative expansion and differentiation into effector cells like Th1, Tfh, and T central memory precursors (Tcmp), most effector CD4+ T cells die, while some survive and become memory cells. Here, we explored how Bcl-2 family memb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d52f88fe18d79a03ba83a24ee4d1e076
https://doi.org/10.1101/2023.03.01.530323
https://doi.org/10.1101/2023.03.01.530323
Autor:
Amy P. Rossi, Simon Tremblay, Cyd M. Castro-Rojas, Ashley A. Burg, Krishna M. Roskin, Jenna M. Gehman, Adele Rike-Shields, Rita R. Alloway, Paul Brailey, David Allman, David A. Hildeman, E. Steve Woodle
Publikováno v:
Am J Transplant
To date, plasma cell (PC)–targeted therapies have been limited by suboptimal PC depletion and antibody rebound. We hypothesized this is partly because of PC residence in protective bone marrow (BM) microenvironments. The purpose of this proof-of-co
Autor:
Tiffany Shi, Ashley R. Burg, J. Timothy Caldwell, Krishna Roskin, Cyd M. Castro-Rojas, P. Chukwunalu Chukwuma, George I. Gray, Sara G. Foote, Jesus Alonso, Carla M. Cuda, David A. Allman, James S. Rush, Catherine H. Regnier, Grazyna Wieczorek, Rita R. Alloway, Adele R. Shields, Brian M. Baker, E. Steve Woodle, David A. Hildeman
Publikováno v:
bioRxiv
Bulk analysis of renal allograft biopsies (rBx) identified RNA transcripts associated with acute cellular rejection (ACR); however, these lacked cellular context critical to mechanistic understanding. We performed combined single cell RNA transcripto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9938d0f073635295d92406b495fcf323
https://doi.org/10.1101/2023.02.08.524808
https://doi.org/10.1101/2023.02.08.524808
Aging mitigates the severity of obesity-associated metabolic sequelae in a gender independent manner
Autor:
Jessica R Doll, Claire A. Chougnet, Traci E. Stankiewicz, Maria E. Moreno-Fernandez, Vishakha Sharma, Jarren R Oates, Senad Divanovic, Maha Almanan, David A. Hildeman, Michelle S M A Damen
Publikováno v:
Nutrition & Diabetes, Vol 11, Iss 1, Pp 1-13 (2021)
Nutrition & Diabetes
Nutrition & Diabetes
Background Understanding gender-associated bias in aging and obesity-driven metabolic derangements has been hindered by the inability to model severe obesity in female mice. Methods Here, using chow- or high fat diet (HFD)-feeding regimens at standar
Autor:
Sarah A. Hummel, David A. Hildeman, Alzbeta Godarova, Tiffany Shi, Michael B. Jordan, A. R. Shields, Rita R. Alloway, Cyd M. Castro-Rojas, Simon Tremblay, E. S. Woodle
Publikováno v:
Transplantation
BACKGROUND: Renal allograft rejection is more frequent under belatacept-based, compared to tacrolimus-based, immunosuppression. We studied kidney transplant recipients experiencing rejection under belatacept-based early corticosteroid withdrawal foll
Autor:
Kun-Po Li, Brian H. Ladle, David A. Hildeman, Sharmila Shanmuganad, Allyson Sholl, Sema Kurtulus
Publikováno v:
Cell Death and Differentiation
Most effector CD8+ T cells die, while some persist and become either “effector” (TEM) or “central” (TCM) memory T cells. Paradoxically, effector CD8+ T cells with greater memory potential have higher levels of the pro-apoptotic molecule Bim.
Autor:
Benjamin Kleeman, David A. Hildeman, H. Leighton Grimes, Matt Kofron, Tess Newkold, Andre Olsson, Monica L. DeLay
Publikováno v:
Cytometry A
The advent of facile genome engineering technologies has made the generation of knock-in gene-expression or fusion-protein reporters more tractable. Fluorescent protein labeling of specific genes combined with surface marker profiling can more specif
Autor:
Kun-Po Li, Sharmila Shanmuganad, David A. Hildeman, Kaitlin R. Carroll, Jonathan D. Katz, Michael B. Jordan
Publikováno v:
Immunological Reviews. 277:21-43
T cells play a critical role in immune responses as they specifically recognize peptide/MHC complexes with their T cell receptors (TCRs) and initiate adaptive immune responses. While T cells are critical for performing appropriate effector functions
Publikováno v:
Critical Care Medicine. 45:e426-e432
Heterogeneity in sepsis-related pathobiology presents a significant challenge. Resolving this heterogeneity presents an opportunity to understand pathobiology and improve patient care. Olfactomedin-4 is a neutrophil subset marker and may contribute t