Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Crystal L Mackall"'
Autor:
Johanna Theruvath, Marie Menard, Benjamin A. H. Smith, Miles H. Linde, Garry L. Coles, Guillermo Nicolas Dalton, Wei Wu, Louise Kiru, Alberto Delaidelli, Elena Sotillo, John L. Silberstein, Anna C. Geraghty, Allison Banuelos, Molly Thomas Radosevich, Shaurya Dhingra, Sabine Heitzeneder, Aidan Tousley, John Lattin, Peng Xu, Jing Huang, Nicole Nasholm, Andy He, Tracy C. Kuo, Emma R. B. Sangalang, Jaume Pons, Amira Barkal, Rachel E. Brewer, Kristopher D. Marjon, Jose G. Vilches-Moure, Payton L. Marshall, Ricardo Fernandes, Michelle Monje, Jennifer R. Cochran, Poul H. Sorensen, Heike E. Daldrup-Link, Irving L. Weissman, Julien Sage, Ravindra Majeti, Carolyn R. Bertozzi, William A. Weiss, Crystal L. Mackall, Robbie G. Majzner
Publikováno v:
Nature medicine, vol 28, iss 2
Nat Med
Nat Med
The disialoganglioside GD2 is overexpressed on several solid tumors, and monoclonal antibodies targeting GD2 have substantially improved outcomes for children with high-risk neuroblastoma. However, approximately 40% of patients with neuroblastoma sti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aad3910b686c28eafa24813f728551c
https://escholarship.org/uc/item/5nz6n240
https://escholarship.org/uc/item/5nz6n240
Autor:
Stacey L. Berg, Kara L. Davis, Brenda J. Weigel, Charles G. Minard, Crystal L. Mackall, Elizabeth Fox, Rachel A. Kudgus, Stephan D. Voss, Melinda S. Merchant, Joel M. Reid, Xiaowei Liu
Publikováno v:
Lancet Oncol
Summary Background Immune checkpoint inhibitors targeting PD-1 have shown clinical benefit in adults with cancer, but data on these drugs in children are scarce. We did a phase 1–2 study of nivolumab, a PD-1 blocking monoclonal antibody, to determi
Publikováno v:
Annual review of cancer biology
Immune-based therapies have now been credentialed for pediatric cancers with the robust efficacy of chimeric antigen receptor (CAR) T cells for pediatric B cell acute lymphocytic leukemia (ALL), offering a chance of a cure for children with previousl
Autor:
Robert C. Jones, Surya Nagaraja, Ansuman T. Satpathy, Michelle Monje, Zinaida Good, Elena Sotillo, Howard Y. Chang, Peng Xu, Hima Anbunathan, Evan W. Weber, Crystal L. Mackall, Rachel C. Lynn, Charles F. A. de Bourcy, David Gennert, John Lattin, Jeffrey M. Granja, Robbie G. Majzner, Victor Tieu, Stephen R. Quake
Publikováno v:
Nature
Chimeric antigen receptor (CAR) T cells mediate anti-tumour effects in a small subset of patients with cancer1-3, but dysfunction due to T cell exhaustion is an important barrier to progress4-6. To investigate the biology of exhaustion in human T cel
Autor:
Lauren Little, Nirali N. Shah, Crystal L. Mackall, Haneen Shalabi, Daniel W. Lee, Seth M. Steinberg, John C. Molina, Bonnie Yates
Publikováno v:
Transplant Cell Ther
Hematopoietic stem cell transplantation (HSCT) may be used to consolidate chimeric antigen receptor (CAR) T cell therapy-induced remissions for patients with relapsed/refractory B cell acute lymphoblastic leukemia (B-ALL), but little is known about t
Autor:
Amin Aalipour, Juliane K. Lohmeyer, Xuhuai Ji, Robert S. Negrin, Kristina Maas-Bauer, Arielle S. Wenokur, Maite Alvarez, Federico Simonetta, Crystal L. Mackall, Toshihito Hirai, Jeanette Baker, Samuel T. Haile
Publikováno v:
Clin Cancer Res
Purpose: The development of allogeneic chimeric antigen receptor (CAR) T-cell therapies for off-the-shelf use is a major goal that faces two main immunologic challenges, namely the risk of graft-versus-host disease (GvHD) induction by the transferred
Autor:
Siddhartha Mitra, Zhongyu Zhu, Anandani Nellan, Johanna Theruvath, Ezio Bonvini, Skyler P. Rietberg, Ravindra Majeti, Christopher Rota, Sabine Heitzeneder, Crystal L. Mackall, Elena Sotillo, Yongzhi Cui, Peng Xu, Alla Sekunova, Christopher Mount, Alberto Delaidelli, John M. Maris, Daniel W. Lee, Michelle Monje, Brad St. Croix, Robbie G. Majzner, Dimiter S. Dimitrov, Miles H. Linde, Poul H. Sorensen, Martha Quezado, Louai Labanieh, Rimas J. Orentas
Publikováno v:
Clin Cancer Res
Purpose: Patients with relapsed pediatric solid tumors and CNS malignancies have few therapeutic options and frequently die of their disease. Chimeric antigen receptor (CAR) T cells have shown tremendous success in treating relapsed pediatric acute l
Autor:
Kevin J. Curran, Nirali N. Shah, Steven A. Rosenberg, Marco L. Davila, Roisin E. O'Cearbhaill, Gary E. Archer, Jean Yuh Tang, Crystal L. Mackall, Richard P. Junghans, Michel Sadelain, Lisa Duffy, Kenneth Cornetta, Renier J. Brentjens, Rosie Kaplan, Hans-Peter Kiem, Steven A. Feldman, Isabelle Riviere, Cindy Delbrook, James N. Kochenderfer
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 10, Iss, Pp 371-378 (2018)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Replication-competent retrovirus (RCR) is a safety concern for individuals treated with retroviral gene therapy. RCR detection assays are used to detect RCR in manufactured vector, transduced cell products infused into research subjects, and in the r
Autor:
Steven A. Feldman, Kara L. Davis, John H. Baird, Robert Lowsky, Rachel C. Lynn, Magali Bazzano, Judith A. Shizuru, Matthew J. Frank, Surbhi Sidana, Maria Caterina Rotiroti, Maria Iglesias, Sean Mackay, Sally Arai, Bita Sahaf, Shabnum Patel, Nirali N. Shah, Laura Johnston, Jay Y. Spiegel, Jing Zhou, Juliana Craig, Robert S. Negrin, Robbie G. Majzner, Andrew R. Rezvani, Zach Ehlinger, Ilan R. Kirsch, Parveen Shiraz, Chelsea D. Mullins, Michael G. Ozawa, Nikolaos Gkitsas, Crystal L. Mackall, Terry J. Fry, Warren D. Reynolds, Yasodha Natkunam, Sneha Ramakrishna, Scott J. Bornheimer, Allison P. Jacob, Lori Muffly, Jean Oak, Haiying Qin, Katherine A. Kong, Wen-Kai Weng, Everett Meyer, Nasheed Hossain, John S. Tamaresis, Sheren F. Younes, David B. Miklos, Liora M. Schultz, Eric J Yang, Harshini Chinnasamy
Publikováno v:
Nature Medicine
Despite impressive progress, more than 50% of patients treated with CD19-targeting chimeric antigen receptor T cells (CAR19) experience progressive disease. Ten of 16 patients with large B cell lymphoma (LBCL) with progressive disease after CAR19 tre
Autor:
Anthony A. Fodor, Erin F. Brooks, Crystal L. Mackall, Farnaz Fouladi, Matthew T. Buckley, Robert S. Negrin, Bita Sahaf, Andrew R. Rezvani, Courtney Greene, Ekaterina Tkachenko, David B. Miklos, Sally Arai, Haley Hedlin, Ami S. Bhatt, Tessa M. Andermann, Fiona B. Tamburini
Publikováno v:
Transplant Cell Ther
Alterations of the gut microbiota after allogeneic hematopoietic cell transplantation (allo-HCT) are a key factor in the development of transplant-related complications such as graft-versus-host disease (GVHD). Interventions that preserve the gut mic