Zobrazeno 41 - 50
of 59
pro vyhledávání: '"Crystal L Mackall"'
Autor:
Robert Korngold, Claude Sportes, Michel Morre, Thomas A. Fleisher, Hua Zhang, Sarfraz Memon, Crystal L. Mackall, Terry J. Fry, Rebecca Babb, Catherine Chow, Renaud Buffet, Kevin S. Chua, Julie Engels, Robert J. Amato, Ronald E. Gress, David Venzon, Andrew L. Pecora, Margaret R. Brown, Frances T. Hakim, Michael Krumlauf
Publikováno v:
The Journal of Experimental Medicine
Interleukin-7 (IL-7) is a homeostatic cytokine for resting T cells with increasing serum and tissue levels during T cell depletion. In preclinical studies, IL-7 therapy exerts marked stimulating effects on T cell immune reconstitution in mice and pri
Autor:
Linda T. Vahdat, Meera Murgai, Rosandra N. Kaplan, Amber J. Giles, Steven L. Highfill, Caitlin M. Reid, David Lyden, Crystal L. Mackall, Justin Evans, Leonard H. Wexler, Miki Kasai, Yorleny Vicioso
Publikováno v:
Cancer research. 76(6)
Metastatic tumors have been shown to establish microenvironments in distant tissues that are permissive to disseminated tumor cells. Hematopoietic cells contribute to this microenvironment, yet the precise initiating events responsible for establishi
Autor:
Donna Bernstein, Lauren Long, Joanne Derdak, Crystal L. Mackall, Haven Battles, Lori Wiener, Patrick J. Mansky
Publikováno v:
Psycho-Oncology. 15:898-910
The long-term psychological impact of pediatric sarcoma is largely unknown. As part of a cross-sectional study examining the late effects of pediatric sarcoma therapy, we examined whether psychological distress or posttraumatic stress symptoms are pr
After decades of research, immunotherapies for cancer are demonstrating increasing success. These agents can amplify existent antitumour immunity or induce durable antitumour immune responses in a wide array of cancers. The spectrum of immunotherapeu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c0d5e93463d7ecaeef18ea0e534b21
https://europepmc.org/articles/PMC6953414/
https://europepmc.org/articles/PMC6953414/
Autor:
Steven A. Rosenberg, Constance M. Yuan, Marianna Sabatino, Terry J. Fry, Ling Zhang, Hua Zhang, Crystal L. Mackall, Rimas J. Orentas, Alan S. Wayne, Steven A. Feldman, Maryalice Stetler-Stevenson, James N. Kochenderfer, Dave Stroncek, Cindy Delbrook, Nick Tschernia, Nirali N. Shah, Seth M. Steinberg, Daniel W. Lee, Yongzhi K Cui
Publikováno v:
Lancet (London, England). 385(9967)
Summary Background Chimeric antigen receptor (CAR) modified T cells targeting CD19 have shown activity in case series of patients with acute and chronic lymphocytic leukaemia and B-cell lymphomas, but feasibility, toxicity, and response rates of cons
Autor:
Warren J. Leonard, Terry J. Fry, John F. Kelly, Amin Al-Shami, Pamela L. Schwartzberg, Crystal L. Mackall, Akhilesh Pandey, Rosanne Spolski
Publikováno v:
The Journal of Experimental Medicine
Thymic stromal lymphopoietin (TSLP) signals via a receptor comprising the interleukin (IL)-7 receptor alpha chain and a distinctive subunit, TSLP receptor (TSLPR), which is most related to the common cytokine receptor gamma chain, gamma(c). We have g
Autor:
Crystal L. Mackall, Edwin M. Horwitz, Jennifer L. Leddon, Kellie B. Haworth, Chun-Yu Chen, Timothy P. Cripe
Publikováno v:
Pediatric bloodcancer. 62(4)
After decades of unfulfilled promise, immunotherapies for cancer have finally reached a tipping point, with several FDA approved products now on the market and many more showing promise in both adult and pediatric clinical trials. Tumor cell expressi
IL-7 plays many essential roles in human health and disease. Congenital deficiencies in IL-7 signaling result in profound immunodeficiency, polymorphisms in IL7Rα modulate susceptibility to autoimmune disease, and acquired somatic activating mutatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe176de09be6cc688057458e2ac728f
https://europepmc.org/articles/PMC3358500/
https://europepmc.org/articles/PMC3358500/
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 17(18)
Purpose: Many solid tumors express cell surface mesothelin making them attractive targets for antibody-based therapies of cancer. SS1P [antimesothelin(Fv)PE38] is a recombinant immunotoxin (RIT) that has potent cytotoxic activity on several cancer ce
Publikováno v:
Nat Rev Immunol
Interleukin-7 (IL-7) is required for T cell development and for maintaining and restoring homeostasis of mature T cells. IL-7 is a limiting resource under normal conditions, but it accumulates during lymphopaenia, leading to increased T cell prolifer