Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Andres J. Klein-Szanto"'
Autor:
John W. Tobias, Mario Andres Blanco, Snahlata Singh, Sushil Kumar, Alana L. Welm, Christopher J. Lengner, Rumela Chakrabarti, Yibin Kang, Christian W. Siebel, Andres J. Klein-Szanto, Ajeya Nandi, Rohan Regulapati, Ning Li
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Development of chemoresistance in breast cancer patients greatly increases mortality. Thus, understanding mechanisms underlying breast cancer resistance to chemotherapy is of paramount importance to overcome this clinical challenge. Although activate
IL-6 Mediates Cross-Talk between Tumor Cells and Activated Fibroblasts in the Tumor Microenvironment
Autor:
Margaret C. Dunagin, Anil K. Rustgi, Qi Long, E. Paul Wileyto, David A. Frank, Andres J. Klein-Szanto, Varun Sahu, Todd J. Waldron, Sarah R. Walker, Edmund Qiao, Arjun Raj, Adam J. Bass, Kwok-Kin Wong, J. Alan Diehl, Shinya Ohashi, Kiichiro Baba, Qiaosi Tang, Devraj Basu, Zachary T. Giaccone, Eric W. Lin, Monica Soni, Tatiana A. Karakasheva
Publikováno v:
Cancer Research. 78:4957-4970
The tumor microenvironment (TME) plays a major role in the pathogenesis of multiple cancer types, including upper-gastrointestinal (GI) cancers that currently lack effective therapeutic options. Cancer-associated fibroblasts (CAF) are an essential co
Autor:
Joel Gabre, Jianwen Que, Angela J. Yoon, Ricardo Cruz-Acuna, Gary W. Falk, Shoji Natsugoe, Adam J. Bass, Julian A. Abrams, Tatiana A. Karakasheva, Lorenzo Ferri, Veena Sangwan, Anil K. Rustgi, Timothy C. Wang, Hiroshi Nakagawa, Varun Sahu, Kelly A. Whelan, Gregory G. Ginsberg, Elizabeth Philipone, J. Alan Diehl, Veronique Giroux, Hisatsugu Maekawa, Andres J. Klein-Szanto, Devraj Basu, Masataka Shimonosono, Takashi Kijima
Publikováno v:
Curr Protoc Stem Cell Biol
Esophageal cancers comprise adenocarcinoma and squamous cell carcinoma, two distinct histologic subtypes. Both are difficult to treat and among the deadliest human malignancies. We describe protocols to initiate, grow, passage, and characterize patie
Autor:
Priya Chatterji, Veronique Giroux, E. Paul Wileyto, Anil K. Rustgi, Kathryn E. Hamilton, Ben Rhoades, Christopher J. Lengner, Julien Stephan, Andres J. Klein-Szanto
Publikováno v:
Stem Cell Reports
Summary Two principal stem cell pools orchestrate the rapid cell turnover in the intestinal epithelium. Rapidly cycling Lgr5+ stem cells are intercalated between the Paneth cells at the crypt base (CBCs) and injury-resistant reserve stem cells reside
Autor:
Kelly A. Whelan, Benjamin J. Wilkins, Okan U. Elci, Evan S. Dellon, Gary W. Falk, Jonathan Gross, Bridget Godwin, Andres J. Klein-Szanto, Hiroshi Nakagawa, Jonathan M. Spergel, Maureen DeMarshall, Amanda B. Muir, Medha Sharma, Alain Benitez, Chris A. Liacouras
Publikováno v:
Clin Gastroenterol Hepatol
Background & Aims Although eosinophil count is the standard used to monitor disease activity in patients with eosinophilic esophagitis (EoE), there are often disparities between patient-reported symptoms and eosinophil counts. We examined the prevale
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9caf01105763de1fa0d9d57e16578429
https://europepmc.org/articles/PMC7058491/
https://europepmc.org/articles/PMC7058491/
Autor:
Fatemeh Momen-Heravi, Hiroshi Nakagawa, Satoshi Takada, Veena Sangwan, Norihiro Matsuura, Andres J. Klein-Szanto, Angela J. Yoon, Koji Tanaka, Samuel Flashner, Uma M. Sachdeva, Lorenzo E. Ferri, Masataka Shimonosono, Eishi Noguchi, J. Alan Diehl, Yasuto Tomita
Publikováno v:
Biomolecules, Vol 11, Iss 1479, p 1479 (2021)
Biomolecules
Volume 11
Issue 10
Biomolecules
Volume 11
Issue 10
Background: Alcohol (ethanol) consumption is a major risk factor for head and neck and esophageal squamous cell carcinomas (SCCs). However, how ethanol (EtOH) affects SCC homeostasis is incompletely understood. Methods: We utilized three-dimensional
Publikováno v:
Biochemical Pharmacology. 140:8-15
Proprotein convertases are serine proteases responsible for the cleavage and subsequent activation of protein substrates, many of them relevant for the development of an ample variety of diseases. Seven of the PCs, including furin and PACE4, recogniz
Autor:
Koji Tanaka, Yoshiaki Kita, Jeffrey D. Winkler, Andres J. Klein-Szanto, Douglas S. Darling, Hiroshi Nakagawa, Satish Srinivasan, Manti Guha, Anil K. Rustgi, Ravi K. Amaravadi, Narayan G. Avadhani, Kelly A. Whelan, Mitsuteru Natsuizaka, Prasanna M. Chandramouleeswaran, Shoji Natsugoe
Publikováno v:
Oncogene
High CD44 expression is associated with enhanced malignant potential in esophageal squamous cell carcinoma (ESCC), among the deadliest of all human carcinomas. Although alterations in autophagy and CD44 expression are associated with poor patient out
Autor:
Edison Mejia, Miguel Garcia-Diaz, Jeelan Basha, Hiroshi Nakagawa, Eric F. Rappaport, Andres J. Klein-Szanto, Narayan G. Avadhani, Tapas K. Kundu, Satish Srinivasan, Ji-Kang Fang, Kip E. Guja, Manti Guha, Gordon Ruthel, Brett A. Kaufman, F. Brad Johnson, M. Rebecca Glineburg
Publikováno v:
Cell Discovery
Cell Discovery, Vol 5, Iss 1, Pp 1-1 (2019)
Cell Discovery, Vol 5, Iss 1, Pp 1-1 (2019)
Reduced mitochondrial DNA copy number, mitochondrial DNA mutations or disruption of electron transfer chain complexes induce mitochondria-to-nucleus retrograde signaling, which induces global change in nuclear gene expression ultimately contributing
Autor:
Anna-Mariya, Kukuyan, Eleonora, Sementino, Yuwaraj, Kadariya, Craig W, Menges, Mitchell, Cheung, Yinfei, Tan, Kathy Q, Cai, Michael J, Slifker, Suraj, Peri, Andres J, Klein-Szanto, Frank J, Rauscher, Joseph R, Testa
Publikováno v:
Cancer research. 79(16)
Pleural malignant mesothelioma (MM) is a therapy-resistant cancer affecting the serosal lining of the thoracic cavity. Mutations/deletions of BAP1, CDKN2A, and NF2 are the most frequent genetic lesions in human MM. We introduced various combinations