Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Ana Martinez-Val"'
Autor:
Jesper V. Olsen, Jos G. A. Smits, Sonia Minuzzo, Giulia Franciosa, Ana Martinez-Val, Stefano Indraccolo
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, 12, 1-19
Nature Communications, 12, 1, pp. 1-19
Nature Communications
Franciosa, G, Smits, J G A, Minuzzo, S, Martinez-Val, A, Indraccolo, S & Olsen, J V 2021, ' Proteomics of resistance to Notch1 inhibition in acute lymphoblastic leukemia reveals targetable kinase signatures ', Nature Communications, vol. 12, no. 1, 2507 . https://doi.org/10.1038/s41467-021-22787-9
Nature Communications, 12, 1-19
Nature Communications, 12, 1, pp. 1-19
Nature Communications
Franciosa, G, Smits, J G A, Minuzzo, S, Martinez-Val, A, Indraccolo, S & Olsen, J V 2021, ' Proteomics of resistance to Notch1 inhibition in acute lymphoblastic leukemia reveals targetable kinase signatures ', Nature Communications, vol. 12, no. 1, 2507 . https://doi.org/10.1038/s41467-021-22787-9
Notch1 is a crucial oncogenic driver in T-cell acute lymphoblastic leukemia (T-ALL), making it an attractive therapeutic target. However, the success of targeted therapy using γ-secretase inhibitors (GSIs), small molecules blocking Notch cleavage an
Autor:
Ana Martinez-Val, Dorte B. Bekker-Jensen, Sophia Steigerwald, Claire Koenig, Ole Østergaard, Adi Mehta, Trung Tran, Krzysztof Sikorski, Estefanía Torres-Vega, Ewa Kwasniewicz, Sólveig Hlín Brynjólfsdóttir, Lisa B. Frankel, Rasmus Kjøbsted, Nicolai Krogh, Alicia Lundby, Simon Bekker-Jensen, Fridtjof Lund-Johansen, Jesper V. Olsen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Martinez-Val, A, Bekker-Jensen, D B, Steigerwald, S, Koenig, C, Østergaard, O, Mehta, A, Tran, T, Sikorski, K, Torres-Vega, E, Kwasniewicz, E, Brynjólfsdóttir, S H, Frankel, L B, Kjøbsted, R, Krogh, N, Lundby, A, Bekker-Jensen, S, Lund-Johansen, F & Olsen, J V 2021, ' Spatial-proteomics reveals phospho-signaling dynamics at subcellular resolution ', Nature Communications, vol. 12, no. 1, 7113 . https://doi.org/10.1038/s41467-021-27398-y
Nature Communications
Martinez-Val, A, Bekker-Jensen, D B, Steigerwald, S, Koenig, C, Østergaard, O, Mehta, A, Tran, T, Sikorski, K, Torres-Vega, E, Kwasniewicz, E, Brynjólfsdóttir, S H, Frankel, L B, Kjøbsted, R, Krogh, N, Lundby, A, Bekker-Jensen, S, Lund-Johansen, F & Olsen, J V 2021, ' Spatial-proteomics reveals phospho-signaling dynamics at subcellular resolution ', Nature Communications, vol. 12, no. 1, 7113 . https://doi.org/10.1038/s41467-021-27398-y
Dynamic change in subcellular localization of signaling proteins is a general concept that eukaryotic cells evolved for eliciting a coordinated response to stimuli. Mass spectrometry-based proteomics in combination with subcellular fractionation can
Autor:
Ana Martinez-Val, Fernando García, Isabel A. Calvo, Eduardo Zarzuela, Pilar Ximénez-Embún, Cian J. Lynch, Manuel Serrano, Javier Munoz
Publikováno v:
Nature Communications
Dipòsit Digital de la UB
Universidad de Barcelona
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Dipòsit Digital de la UB
Universidad de Barcelona
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Embryonic stem cells (ESCs) can be maintained in the naïve state through inhibition of Mek1/2 and Gsk3 (2i). A relevant effect of 2i is the inhibition of Cdk8/19, which are negative regulators of the Mediator complex, responsible for the activity of
Autor:
Tejas Gandhi, Ana Martinez-Val, Christian D. Kelstrup, Lynn Verbeke, Dorte B. Bekker-Jensen, Oliver M. Bernhardt, Lukas Reiter, Alexander Hogrebe, Jesper V. Olsen
Publikováno v:
Bekker-Jensen, D B, Bernhardt, O M, Hogrebe, A, Martinez-Val, A, Verbeke, L, Gandhi, T, Kelstrup, C D, Reiter, L & Olsen, J V 2020, ' Rapid and site-specific deep phosphoproteome profiling by data-independent acquisition without the need for spectral libraries ', Nature Communications, vol. 11, no. 1, 787 . https://doi.org/10.1038/s41467-020-14609-1
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Quantitative phosphoproteomics has transformed investigations of cell signaling, but it remains challenging to scale the technology for high-throughput analyses. Here we report a rapid and reproducible approach to analyze hundreds of phosphoproteomes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e453d00707c07c35b75c671a2f2b94a
https://curis.ku.dk/portal/da/publications/rapid-and-sitespecific-deep-phosphoproteome-profiling-by-dataindependent-acquisition-without-the-need-for-spectral-libraries(c58b93b3-99f8-4b09-897a-9c279dc8d2c3).html
https://curis.ku.dk/portal/da/publications/rapid-and-sitespecific-deep-phosphoproteome-profiling-by-dataindependent-acquisition-without-the-need-for-spectral-libraries(c58b93b3-99f8-4b09-897a-9c279dc8d2c3).html
Autor:
Nuria Ibarz, Gonzalo Gómez-López, Oscar Fernandez-Capetillo, Raquel Bernad, Ana Martinez-Val, Javier Munoz, Enrique Rojo, Isabel A. Calvo, Sergio Ruiz, Osvaldo Graña-Castro, Vladimir Espinosa Angarica, Sagrario Ortega, Sandrina Nóbrega-Pereira, Eduardo Andrés-León, Cian J. Lynch, Manuel Serrano, Antonio del Sol
Publikováno v:
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
Cell Reports, Vol 22, Iss 2, Pp 396-410 (2018)
Repisalud
Instituto de Salud Carlos III (ISCIII)
Cell Reports
Digital.CSIC. Repositorio Institucional del CSIC
instname
Cell Reports, Vol 22, Iss 2, Pp 396-410 (2018)
Repisalud
Instituto de Salud Carlos III (ISCIII)
Cell Reports
Digital.CSIC. Repositorio Institucional del CSIC
Summary The RNA polymerase II-associated protein 1 (RPAP1) is conserved across metazoa and required for stem cell differentiation in plants; however, very little is known about its mechanism of action or its role in mammalian cells. Here, we report t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::174361f09000f2c2ddd63b29984d7535
http://hdl.handle.net/10486/683939
http://hdl.handle.net/10486/683939