Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Amy Belton"'
Autor:
Michael Koo, James Turkson, David L. Huso, Tait Huso, Patrick T. Gunning, Lingling Xian, Guosheng Liu, Brent D. G. Page, Amy Belton, Li Z. Luo, Linda M.S. Resar
Publikováno v:
Leukemia & Lymphoma. 57:2681-2684
Despite dramatic improvements in treatment and survival, acute lymphoid malignancies remain the leading cause of death in children with cancer and a highly lethal malignancy in adults.[1] Acute lym...
Autor:
Leslie Cope, Linda M.S. Resar, Wenyong Kuang, Lingling Xian, David L. Huso, Andrew J. Ewald, Stefania Senger, Amy Belton, Tait Huso, Alessio Fasano, Dan Georgess, Yu Ting Chang, Xiaoyan Zhang, Qihua Gu
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
High-mobility group A1 (Hmga1) chromatin remodelling proteins are enriched in intestinal stem cells (ISCs), although their function in this setting was unknown. Prior studies showed that Hmga1 drives hyperproliferation, aberrant crypt formation and p
Autor:
Leslie Cope, Tait Huso, Andrew Schuldenfrei, Linda M.S. Resar, Nathaniel R. Campbell, Collins Karikari, David L. Huso, Francescopaolo Di Cello, Dwella M. Nelson, Amy Belton, Anirban Maitra, Abimbola Aderinto, Shamayra S. Smail, Sandeep N. Shah, Joelle Hillion
Publikováno v:
Pancreatology. 12:372-379
Although pancreatic cancer is a common, highly lethal malignancy, the molecular events that enable precursor lesions to become invasive carcinoma remain unclear. We previously reported that the high-mobility group A1 (HMGA1) protein is overexpressed
Autor:
Biju Joseph, Francescopaolo Di Cello, Alexandra C. Hristov, Amy Belton, Joelle Hillion, Christine A. Iacobuzio-Donahue, Marcelo Delos Reyes, Anirban Maitra, Andrew Schuldenfrei, Linda M.S. Resar, Leslie Cope, Mansher Singh
Publikováno v:
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Although pancreatic ductal adenocarcinoma is a common and almost uniformly fatal cancer, little is known about the molecular events that lead to tumor progression. The high-mobility group A1 (HMGA1) protein is an architectural transcription factor th
Autor:
Amy Belton, Francescopaolo Di Cello, Jeanne Kowalski, Alexandra C. Hristov, William L. Carroll, Deepa Bhojwani, Linda M.S. Resar, Julia Meyer, Sujayita Roy, Hua Ling Tsai
Despite dramatic improvements in treatment and survival, acute lymphoblastic leukemic (ALL) remains the leading cause of death in children with cancer [1]. ALL is the most common pediatric cancer, ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::114978f6f463c8af541fdeb8181e47b1
https://europepmc.org/articles/PMC5036165/
https://europepmc.org/articles/PMC5036165/
Autor:
Ossama Elbahloul, Stanley Zucker, Charles M. Rudin, Linda M.S. Resar, Lisa Wood, Joelle Hillion, Amy Belton, Biju Joseph, Francescopaolo Di Cello, Mita Mukherjee, Jeanne Kowalski, John T. Poirier, Raka Bhattacharya, Surajit Dhara, Jodi B Segal
Publikováno v:
Molecular cancer research : MCR. 7(11)
Although lung cancer is the leading cause of cancer death worldwide, the precise molecular mechanisms that give rise to lung cancer are incompletely understood. Here, we show that HMGA1 is an important oncogene that drives transformation in undiffere
Autor:
Linda M.S. Resar, Francescopaolo Di Cello, Peter D. Aplan, Takita Felder Sumter, James Turkson, Joelle Hillion, Ying Wei Lin, Amy Belton, Zhaohui Ye, Soumya Jaganathan, Richard Jove, Kelsey J. Wertzler, Jeanne Kowalski, Ray Reeves, Surajit Dhara, Mita Mukherjee, Ossama Elbahlouh, Linzhao Cheng, Raka Bhattacharya
Although HMGA1 (high-mobility group A1; formerly HMG-I/Y) is an oncogene that is widely overexpressed in aggressive cancers, the molecular mechanisms underlying transformation by HMGA1 are only beginning to emerge. HMGA1 encodes the HMGA1a and HMGA1b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::562f5898023eef739b597aecdd1d67ec
https://europepmc.org/articles/PMC2913892/
https://europepmc.org/articles/PMC2913892/
Publikováno v:
Mechanisms of ageing and development. 128(11-12)
Manganese superoxide dismutase (MnSOD or SOD2) is a key mitochondrial enzymatic antioxidant. Arguably the most striking phenotype associated with complete loss of SOD2 in flies and mice is shortened life span. To further explore the role of SOD2 in p