Zobrazeno 1 - 10
of 143
pro vyhledávání: '"Alan R. Shuldiner"'
Autor:
Simeon I. Taylor, Hua-Ren Cherng, Zhinous Shahidzadeh Yazdi, May E. Montasser, Hilary B. Whitlatch, Braxton D. Mitchell, Alan R. Shuldiner, Elizabeth A. Streeten, Amber L. Beitelshees
Publikováno v:
medRxiv
BackgroundSGLT2 inhibitors provide multiple benefits to patients with type 2 diabetes – including improved glycemic control and decreased risks of cardiorenal disease. Because drug responses vary among individuals, we initiated investigations to id
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b37de4f2f3b80e0b759c43bbdab89f85
https://doi.org/10.1101/2023.03.07.23286875
https://doi.org/10.1101/2023.03.07.23286875
Autor:
Robert L. Hanson, Clifton Bogardus, Nehal Gosalia, Leslie J. Baier, Robert C. Williams, Alan R. Shuldiner, Cristopher V. Van Hout, Çiğdem Köroğlu, William C. Knowler
Publikováno v:
Hum Immunol
While the samples and data from the Pima Indians of the Gila River Indian Community have been included in many international HLA workshops and conferences and have been the focus of numerous population reports and the source of novel alleles at the c
Autor:
Jack A. Kosmicki, Charles Paulding, Nan Lin, Andrew J. Murphy, Jerome I. Rotter, Brian Zambrowicz, Niek Verweij, Luca A. Lotta, Michal L. Schwartzman, Giusy Della Gatta, Yii-Der Ida Chen, Alexander H. Li, Suganthi Balasubramanian, Jason M. Torres, Hyun Min Kang, Rory Collins, Parsa Akbari, Michael E. Dunn, Gonçalo R. Abecasis, Christian Benner, David J. Carey, Svati H. Shah, Jonathan Marchini, Giovanni Coppola, Marcus B. Jones, Olle Melander, Christopher D. Still, Yi-Ya Fang, Olukayode A. Sosina, Manuel A. R. Ferreira, Roberto Tapia-Conyer, Michael Cantor, Aris N. Economides, Dylan Sun, Adam E. Locke, Jonathan V. Pascale, Daniel J. Rader, Ankit Gilani, Joelle Mbatchou, Jesus Alegre-Díaz, Mark W. Sleeman, Trikaldarshi Persaud, Jeffrey G. Reid, Pablo Kuri-Morales, Jaime Berumen-Campos, John D. Overton, Aris Baras, Ercument Dirice, Sakib Hossain, Alicia Hawes, George D. Yancopoulos, Jonathan Emberson, Victor Garcia, Judith Altarejos, Lori Khrimian, Katia Karalis, William E. Kraus, Tooraj Mirshahi, Kevin Agostinucci, Alan R. Shuldiner
Publikováno v:
Science
Introduction Obesity accounts for a substantial and growing burden of disease globally. Body adiposity is highly heritable, and human genetic studies can lead to biological and therapeutic insights. Rationale Whole-exome sequencing of hundreds of tho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df724bff85dd4d7320fb650eae3fa2a5
https://doi.org/10.1126/science.abf8683
https://doi.org/10.1126/science.abf8683
Autor:
David J. Carey, Cristen J. Willer, Anthony Marcketta, Claudia Schurmann, Leland Barnard, John Penn, Suganthi Balasubramanian, Daren Liu, Joseph B. Leader, Gonçalo R. Abecasis, Marcus B. Jones, John C. Whittaker, Ashutosh K. Pandey, Ida Surakka, David H. Ledbetter, Evan Maxwell, John D. Overton, Andrew Blumenfeld, Michael N. Cantor, Robert A. Scott, Wendy K. Chung, Alexander H. Li, Alexander Lopez, Joshua D. Backman, Matthew R. Nelson, Jeffrey Staples, Giovanni Coppola, Jonathan Marchini, Xiaodong Bai, Kavita Praveen, Alan R. Shuldiner, Claudia Gonzaga-Jauregui, Aris N. Economides, Shareef Khalid, William J Salerno, Bin Ye, Cristopher V. Van Hout, Kristian Hveem, Jeffrey G. Reid, Colm O'Dushlaine, Joshua D. Hoffman, Laura M. Yerges-Armstrong, Nilanjana Banerjee, Sean O'Keeffe, Ioanna Tachmazidou, Lon R. Cardon, Alicia Hawes, Aris Baras, Ashish Yadav, George D. Yancopoulos, Lukas Habegger
Publikováno v:
Nature
The UK Biobank is a prospective study of 502,543 individuals, combining extensive phenotypic and genotypic data with streamlined access for researchers around the world1. Here we describe the release of exome-sequence data for the first 49,960 study
Autor:
Cristopher V. Van Hout, Leslie J. Baier, Alan R. Shuldiner, Madhumita Sinha, Robert L. Hanson, William C. Knowler, Wen-Chi Hsueh, Sayuko Kobes
Publikováno v:
Diabetologia
AIMS/HYPOTHESIS: Prevalence of type 2 diabetes differs among human ancestry groups, and many hypotheses invoke differential natural selection to account for these differences. We sought to assess the potential role of differential natural selection a
Autor:
Nehal Gosalia, Cristopher V. Van Hout, John D. Overton, Omri Gottesman, Ryan Murchie, Aris Baras, Alan R. Shuldiner, Claudia Gonzaga-Jauregui, Gabriel Welch, Aleixo M. Muise, Jeffrey G. Reid, Julie E. Horowitz, Karoline Fiedler, Neil Warner, Anne M. Griffiths, Alejandra King, Eileen Crowley, Jeffrey Staples
Publikováno v:
Paediatrics Publications
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Inflammatory bowel disease (IBD), clinically defined as Crohn’s disease (CD), ulcerative colitis (UC), or IBD-unclassified, results in chronic inflammation of the gastrointestinal tract in genetically susceptible hosts. Pediatric onset IBD represen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21923c551e5578f0d9e38862eb408d7b
https://ir.lib.uwo.ca/context/paedpub/article/2012/viewcontent/s41598_021_84938_8.pdf
https://ir.lib.uwo.ca/context/paedpub/article/2012/viewcontent/s41598_021_84938_8.pdf
Autor:
Tove Fall, Anubha Mahajan, Dmitry Shungin, B. Balkau, Gerjan Navis, A. Metspalu, Anneli Pouta, Andrew A. Hicks, Ilja M. Nolte, Ian Ford, Aroon D. Hingorani, Stefan R Bornstein, Anuj Goel, Rona J. Strawbridge, Niek Verweij, Sarah H. Wild, Patricia B. Munroe, T.B. Harris, Jaana Lindström, Johnson Pcd., Nita G. Forouhi, Pierre Meneton, Patricia A. Peyser, Sarin A-P., Andrea Ganna, Timothy M. Frayling, Patrik K. E. Magnusson, Joanne M. Meyer, Yongmei Liu, Jeanette M. Stafford, Christian Herder, L Zudina, Maria G. Stathopoulou, May E. Montasser, Nicholas D. Hastie, Inês Barroso, Schwarz Peh., James B. Meigs, Perttu Salo, George Davey Smith, Gonneke Willemsen, Christopher J. Groves, Erik P A Van Iperen, M. A. Province, Veikko Salomaa, Naveed Sattar, Serena Sanna, Maria Dimitriou, Joop Jukema, Ulrika Krus, Albert V. Smith, Markku Laakso, James F. Wilson, George Nicholson, Loic Yengo, Tatijana Zemunik, Per Eriksson, Harold Snieder, Peter P. Pramstaller, Claudia Langenberg, R. Rauramaa, Alan R. Shuldiner, Pau Navarro, Veronique Vitart, Ross M. Fraser, Aaron Isaacs, C. Lecoeur, Jesper R. Gådin, Jackie F. Price, Letizia Marullo, L.F. Bielak, Sirkka Keinänen-Kiukaanniemi, Amélie Bonnefond, Michael Stumvoll, Alessia Faggian, Anke Tönjes, Tomohiro Tanaka, Wieland Kiess, Harry Campbell, Josée Dupuis, David Altshuler, João Fadista, Winfried März, G K Hovingh, Thomas Illig, Toby Johnson, H Grallert, Kari Stefansson, Reedik Mägi, Palmer Cna., de Geus Ejcn., Martina Müller-Nurasyid, Karen Kapur, Philippe Froguel, Dorret I. Boomsma, Anders Franco-Cereceda, Marcus E. Kleber, Boehnke M, Olga D. Carlson, Ozren Polasek, Andrew P. Morris, Alex S. F. Doney, Najaf Amin, Sara M. Willems, Vilmundur Gudnason, Jose C. Florez, Jeffery R. O'Connell, Nancy L. Pedersen, T. Saaristo, Wolffenbuttel Bhr., M. I. J. Uusitupa, Longda Jiang, Iva Miljkovic, James S. Pankow, Caroline Hayward, Hugh Watkins, Vasiliki Lagou, Johanna Kuusisto, Jaakko Tuomilehto, Alan F. Wright, Josephine M. Egan, Perry Jrb., C M van Duijn, Valeriya Lyssenko, Leif Groop, Stefania Bandinelli, Nigel W. Rayner, Tõnu Esko, Stela McLachlan, Momoko Horikoshi, Eric Boerwinkle, Rick Jansen, Richard N. Bergman, Gudmar Thorleifsson, Lyle J. Palmer, Vilmantas Giedraitis, Peter Kovacs, Nicholas J. Wareham, Luigi Ferrucci, N J Timpson, D Rybin, Anne U. Jackson, Tiinamaija Tuomi, Gonçalo R. Abecasis, Harst Pvd., Meena Kumari, Albert Hofman, Chiara Scapoli, Evelin Mihailov, Josine L. Min, Anders Hamsten, Hottenga J-J., Loos Rjf., Lars Lind, Ulf de Faire, Jaakko Kaprio, Guo Li, Beate St Pourcain, C Gieger, Amanda J. Bennett, Anna Ulrich, Nabila Bouatia-Naji, Satu Männistö, Antigone S. Dimas, Jarvelin M-R., Günther Silbernagel, F Karpe, A. Körner, David S. Siscovick, M Blüher, Rebecca J. Webster, Erik Ingelsson, Susan Campbell, Mika Kivimäki, Laura J. Rasmussen-Torvik, Heikki A. Koistinen, Sophie Visvikis-Siest, Bernhard O. Boehm, Inga Prokopenko, Ping An, Emmanouil T. Dermitzakis, Cecilia M. Lindgren, Kardia Slr., Richa Saxena, Igor Rudan, Richard M. Watanabe, Jian'an Luan, Marika Kaakinen, Shin S-Y., George Dedoussis, Panagiotis Deloukas, Mark I. McCarthy, Barbara Thorand, B.W.J.H. Penninx, Peter Vollenweider, Paul W. Franks, Leena Kinnunen, Markus Perola, Yvonne Boettcher, Timo A. Lakka, Nicole Soranzo, Stavroula Kanoni, Bakker Sjl., Winkelmann Br
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.24. ⟨10.1038/s41467-020-19366-9⟩
Nature communications, 12(1):24. Nature Publishing Group
Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) 2021, ' Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability ', Nature Communications, vol. 12, no. 1, 24 . https://doi.org/10.1038/s41467-020-19366-9, https://doi.org/10.1038/s41467-020-19366-9
Nature Communications, 2021, 12 (1), pp.24. ⟨10.1038/s41467-020-19366-9⟩
Nature Communications, 12(1):24, 1-18. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications, 12(1):24. Nature Publishing Group
Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) 2021, ' Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability ', Nature Communications, vol. 12, no. 1, 24 . https://doi.org/10.1038/s41467-020-19366-9
Nature Communications, 12(1):24. Nature Publishing Group UK
Lagou, V, Mägi, R, Hottenga, J J, Jansen, R, Min, J L, Willemsen, G, De Geus, E J C N, Penninx, B W, Boomsma, D I, Barroso, I, Morris, A P, Prokopenko, I & MAGIC Collaboration 2021, ' Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability ', Nature Communications, vol. 12, no. 1, 24, pp. 1-18 . https://doi.org/10.1038/s41467-020-19366-9
Min, J L, St Pourcain, M U B, Timpson, N J, Davey Smith, G, Prokopenko, I & et al. 2021, ' Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability ', Nature Communications, vol. 12, 24 . https://doi.org/10.1038/s41467-020-19366-9
2021, ' Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability ', Nature Communications, vol. 12, no. 1, 24 . https://doi.org/10.1038/s41467-020-19366-9, https://doi.org/10.1038/s41467-021-21276-3
Nature communications, vol. 12, no. 1, pp. 24
Nature Communications, 12(1). NATURE RESEARCH
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.24. ⟨10.1038/s41467-020-19366-9⟩
Nature communications, 12(1):24. Nature Publishing Group
Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) 2021, ' Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability ', Nature Communications, vol. 12, no. 1, 24 . https://doi.org/10.1038/s41467-020-19366-9, https://doi.org/10.1038/s41467-020-19366-9
Nature Communications, 2021, 12 (1), pp.24. ⟨10.1038/s41467-020-19366-9⟩
Nature Communications, 12(1):24, 1-18. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Nature Communications, 12(1):24. Nature Publishing Group
Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC) 2021, ' Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability ', Nature Communications, vol. 12, no. 1, 24 . https://doi.org/10.1038/s41467-020-19366-9
Nature Communications, 12(1):24. Nature Publishing Group UK
Lagou, V, Mägi, R, Hottenga, J J, Jansen, R, Min, J L, Willemsen, G, De Geus, E J C N, Penninx, B W, Boomsma, D I, Barroso, I, Morris, A P, Prokopenko, I & MAGIC Collaboration 2021, ' Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability ', Nature Communications, vol. 12, no. 1, 24, pp. 1-18 . https://doi.org/10.1038/s41467-020-19366-9
Min, J L, St Pourcain, M U B, Timpson, N J, Davey Smith, G, Prokopenko, I & et al. 2021, ' Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability ', Nature Communications, vol. 12, 24 . https://doi.org/10.1038/s41467-020-19366-9
2021, ' Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability ', Nature Communications, vol. 12, no. 1, 24 . https://doi.org/10.1038/s41467-020-19366-9, https://doi.org/10.1038/s41467-021-21276-3
Nature communications, vol. 12, no. 1, pp. 24
Nature Communications, 12(1). NATURE RESEARCH
Differences between sexes contribute to variation in the levels of fasting glucose and insulin. Epidemiological studies established a higher prevalence of impaired fasting glucose in men and impaired glucose tolerance in women, however, the genetic c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5783e9d2579548e3deb52d1bbdf19db
https://hal.univ-lorraine.fr/hal-03105716
https://hal.univ-lorraine.fr/hal-03105716
Autor:
Robert L. Hanson, Leslie J. Baier, Nehal Gosalia, Hye In Kim, Çiğdem Köroğlu, Bin Ye, Alan R. Shuldiner, Clifton Bogardus, Cristopher V. Van Hout, Wen-Chi Hsueh, William C. Knowler
Publikováno v:
Am J Hum Genet
Applying exome sequencing to populations with unique genetic architecture has the potential to reveal novel genes and variants associated with traits and diseases. We sequenced and analyzed the exomes of 6,716 individuals from a Southwestern American
Autor:
Mark Nelson, Christopher M. Reid, Sophia Xie, Joshua P. Lewis, Alan R. Shuldiner, Andrew Tonkin, Paul Lacaze, Rory Wolfe, John J McNeil, Galina Polekhina, Anne M. Murray, Moeen Riaz
Publikováno v:
Clin Pharmacol Ther
The platelet endothelial aggregation receptor-1 (PEAR1) rs12041331 variant has been identified as a genetic determinant of platelet aggregation in response to antiplatelet therapies, including aspirin. However, association with atherothrombotic cardi
Autor:
Xuemei Huang, Toni I. Pollin, Alan R. Shuldiner, Lan Kong, Katherine A. Ryan, Honglei Chen, Richard B. Mailman, John W. Stiller, Mary Pavlovich, Teodor T. Postolache, Michael Goldenberg, Braxton D. Mitchell
Publikováno v:
Neuroepidemiology
Introduction: Previous research has suggested that the Amish may experience a relatively high prevalence of Parkinson’s disease (PD) and/or parkinsonian motor signs. Methods: In a large sample from the Amish community in Lancaster County, Pennsylva