Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Mandy L. Ford"'
Autor:
Ching-Wen Chen, Craig M. Coopersmith, Mandy L. Ford, Deena B. Chihade, Wenxiao Zhang, Zhe Liang, Alton B. Farris, John D. Lyons, Eileen M. Burd
Publikováno v:
Shock
Patients with cancer who develop sepsis have a markedly higher mortality than patients who were healthy prior to the onset of sepsis. Potential mechanisms underlying this difference have previously been examined in two preclinical models of cancer fo
Autor:
Shunsuke Otani, Rebecca L. Crepeau, Jianfeng Xie, Mandy L. Ford, Ching-Wen Chen, Wenxiao Zhang, Craig M. Coopersmith
Publikováno v:
Journal of Leukocyte Biology. 105:565-575
Epstein–Barr virus (EBV) reactivation commonly occurs following sepsis, but the mechanisms underlying this are unknown. We utilized a murine EBV homolog (gHV) and the cecal ligation and puncture model of polymicrobial sepsis to study the impact of
Autor:
Nathan J. Klingensmith, Ching-Wen Chen, Katherine T. Fay, Mandy L. Ford, Zhe Liang, Mei Meng, Craig M. Coopersmith, John D. Lyons
Publikováno v:
Shock. 51:88-96
The gut is a continuously renewing organ, with cell proliferation, migration and death occurring rapidly under basal conditions. Since the impact of critical illness on cell movement from crypt base to villus tip is poorly understood, the purpose of
Autor:
Ashley A. Miniet, Eileen M. Burd, Craig M. Coopersmith, Zhe Liang, Yini Sun, Mandy L. Ford, Takehiko Oami
Publikováno v:
Shock
Sepsis-induced intestinal hyperpermeability is mediated by disruption of the epithelial tight junction, which is closely associated with the peri-junctional actin-myosin ring. Genetic deletion of myosin light chain kinase (MLCK) reverses intestinal h
Autor:
Yini, Sun, Jianfeng, Xie, Jerome C, Anyalebechi, Ching-Wen, Chen, He, Sun, Ming, Xue, Zhe, Liang, Kristen N, Morrow, Craig M, Coopersmith, Mandy L, Ford
Publikováno v:
J Immunol
Immune dysregulation during sepsis is mediated by an imbalance of T cell costimulatory and coinhibitory signaling. CD28 is downregulated during sepsis and is significantly altered on memory versus naive T cells. Thus, to study the role of CD28 during
Publikováno v:
Sci Transl Med
The interaction between tetranectin and high-mobility group box-1 may be manipulated via monoclonal antibodies to improve survival in sepsis (Chen et al ., same issue).
Autor:
Elise R. Breed, Eileen M. Burd, Rudolph L. Gleason, Benyam P. Yoseph, Craig M. Coopersmith, Zhe Liang, Carolyn A. Hilliard, Clayton R. Hunt, Ching-Wen Chen, Luke P. Brewster, Laura Hansen, Mandy L. Ford, Rohit Mittal, Tej K. Pandita
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports
Scientific Reports
In vitro studies have implicated the small heat shock protein HSPB1 in a range of physiological functions. However, its in vivo relevance is unclear as the phenotype of unstressed HSPB1−/− mice is unremarkable. To determine the impact of HSPB1 in
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1863:2574-2583
The gastrointestinal tract has long been hypothesized to function as “the motor” of multiple organ dysfunction syndrome. The gastrointestinal microenvironment is comprised of a single cell layer epithelia, a local immune system, and the microbiom
Autor:
Craig M. Coopersmith, Ming Xue, Yini Sun, Deena B. Chihade, Zhe Liang, Ching-Wen Chen, Mandy L. Ford, Kristen N. Morrow
Publikováno v:
iScience, Vol 24, Iss 2, Pp 102093-(2021)
iScience
iScience
Summary Sepsis is a leading cause of morbidity and mortality associated with significant impairment in memory T cells. These changes include the upregulation of co-inhibitory markers, a decrease in functionality, and an increase in apoptosis. Due to
Autor:
Eileen M. Burd, Alton B. Farris, Zhe Liang, Mandy L. Ford, Nathan J. Klingensmith, Jack L. Arbiser, Ching-Wen Chen, Craig M. Coopersmith
Honokiol is a biphenolic isolate extracted from the bark of the magnolia tree that has been used in traditional Chinese and Japanese medicine, and has more recently been investigated for its anti-inflammatory and anti-bacterial properties. Honokiol h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f098a00ec615781395d8fc18c96441a
https://europepmc.org/articles/PMC5895534/
https://europepmc.org/articles/PMC5895534/