Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Hariharan Easwaran"'
Autor:
Sharon Wu, Elizabeth M. Jaffee, Joanne Xiu, Evanthia T. Roussos Torres, Jerry Lee, Ashani T. Weeraratna, Claudine Isaacs, Michael J. Topper, Jennifer La, Ilya G. Serebriiskii, Igor Astsaturov, Reva Basho, Rossin Erbe, Marc E. Lippman, Elana J. Fertig, Nathanael Fillmore, Hariharan Easwaran, Zheyu Wang, Nicolas A. Giraldo, John Marshall, Josephine A. Taverna, Neeha Zaidi, David Tuck, Stephen B. Baylin, Heinz-Josef Lenz
Publikováno v:
Cell Reports, Vol 37, Iss 7, Pp 110033-(2021)
Cell reports
Cell Reports, Vol 36, Iss 8, Pp 109599-(2021)
Cell reports
Cell Reports, Vol 36, Iss 8, Pp 109599-(2021)
SUMMARY Both tumors and aging alter the immune landscape of tissues. These interactions may play an important role in tumor progression among elderly patients and may suggest considerations for patient care. We leverage large-scale genomic and clinic
Autor:
Yang W. Zhang, Wenbing Xie, Ray Whay Chiu Yen, Hariharan Easwaran, Limin Xia, Yana Li, Zhihong Wang, Yi Cai, Jianjun Luo, Stephen B. Baylin
Publikováno v:
Molecular Cell. 65:323-335
TET proteins, by converting 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), are hypothesized, but not directly shown, to protect promoter CpG islands (CGIs) against abnormal DNA methylation (DNAm) in cancer. We define such a protective role
Publikováno v:
Molecular Cell. 54:716-727
The existence of subpopulations of cells in cancers with increased tumor-initiating capacities and self-renewal potential, often termed "cancer stem cells," is a much discussed and key area of cancer biology. Such cellular heterogeneity is very impor
Autor:
Stephen B. Baylin, Subhojit Sen, Leslie Cope, Leander Van Neste, Gayle Jeannette Pageau, Kornel E. Schuebel, Hariharan Easwaran, Jeanne B. Lawrence, Helai P. Mohammad, James G. Herman
Publikováno v:
Cancer Research. 70:8015-8024
Aberrant promoter DNA-hypermethylation and repressive chromatin constitutes a frequent mechanism of gene inactivation in cancer. There is great interest in dissecting the mechanisms underlying this abnormal silencing. Studies have shown changes in th
Autor:
Helai P. Mohammad, Heather M. O'Hagan, Stephen B. Baylin, Joyce E. Ohm, Yi Cai, Hariharan Easwaran, Leander Van Neste, Kelly M. McGarvey
Publikováno v:
Cancer Research. 69:6322-6330
Epigenetic silencing of genes in association with aberrant promoter DNA hypermethylation has emerged as a significant mechanism in the development of human cancers. Such genes are also often targets of the polycomb group repressive complexes in embry