Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Mandy L. Ford"'
Autor:
Mandy L. Ford, Yini Sun, Jennifer M. Robertson, Aneesh K. Mehta, Marvi Tariq, Scott M. Krummey, Christina R. Hartigan, He Sun, Ching wen Chen
Publikováno v:
Am J Transplant
Belatacept confers increased patient and graft survival in renal transplant recipients relative to calcineurin inhibitors, but is associated with an increased rate of acute rejection. Recent immunophenotypic studies comparing pre-transplant T cell ph
Publikováno v:
Am J Transplant
CTLA-4Ig (belatacept) blocks the CD80/CD86 ligands for both CD28 and CTLA-4; thus, in addition to the intended effect of blocking CD28-mediated costimulation, belatacept also has the unintended effect of blocking CTLA-4-mediated coinhibition. Recentl
Autor:
Ching-Wen Chen, Craig M. Coopersmith, Mandy L. Ford, Deena B. Chihade, Wenxiao Zhang, Zhe Liang, Alton B. Farris, John D. Lyons, Eileen M. Burd
Publikováno v:
Shock
Patients with cancer who develop sepsis have a markedly higher mortality than patients who were healthy prior to the onset of sepsis. Potential mechanisms underlying this difference have previously been examined in two preclinical models of cancer fo
Autor:
Shunsuke Otani, Rebecca L. Crepeau, Jianfeng Xie, Mandy L. Ford, Ching-Wen Chen, Wenxiao Zhang, Craig M. Coopersmith
Publikováno v:
Journal of Leukocyte Biology. 105:565-575
Epstein–Barr virus (EBV) reactivation commonly occurs following sepsis, but the mechanisms underlying this are unknown. We utilized a murine EBV homolog (gHV) and the cecal ligation and puncture model of polymicrobial sepsis to study the impact of
Autor:
Nathan J. Klingensmith, Ching-Wen Chen, Katherine T. Fay, Mandy L. Ford, Zhe Liang, Mei Meng, Craig M. Coopersmith, John D. Lyons
Publikováno v:
Shock. 51:88-96
The gut is a continuously renewing organ, with cell proliferation, migration and death occurring rapidly under basal conditions. Since the impact of critical illness on cell movement from crypt base to villus tip is poorly understood, the purpose of
Autor:
Glenn Michael La Muraglia, Idelberto R. Badell, Emma S. Crichton, Maylene E. Wagener, Susan Zeng, Mandy L. Ford
Publikováno v:
Am J Transplant
Anti-donor antibodies cause immunologic injury in transplantation. CD28 blockade with CTLA-4-Ig has the ability to reduce the incidence of these donor-specific antibodies (DSA), but its mechanism is suboptimal for the inhibition of alloimmunity in th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64f3dc80ed22866d214e692620daa73b
https://europepmc.org/articles/PMC7665991/
https://europepmc.org/articles/PMC7665991/
Autor:
Rebecca L. Crepeau, Mandy L. Ford
Publikováno v:
Cell Immunol
While T cells play a critical role in protective immunity against infection, they are also responsible for graft rejection in the setting of transplantation. T cell differentiation is regulated by both intrinsic transcriptional pathways as well as ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e4d1730f8e0dd0ae683761b1aa4bb44
https://europepmc.org/articles/PMC7198981/
https://europepmc.org/articles/PMC7198981/
Autor:
Danya Liu, Maylene E. Wagener, G. Ding, Idelberto R. Badell, G. M. La Muraglia, Mandy L. Ford
Publikováno v:
American Journal of Transplantation. 18:89-101
Donor-specific antibodies (DSA) are a barrier to improved long-term outcomes following kidney transplantation. Costimulation blockade with CTLA-4-Ig has shown promise as a potential therapeutic strategy to control DSA. T follicular helper (Tfh) cells
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 1863:2574-2583
The gastrointestinal tract has long been hypothesized to function as “the motor” of multiple organ dysfunction syndrome. The gastrointestinal microenvironment is comprised of a single cell layer epithelia, a local immune system, and the microbiom
Autor:
Pamela D. Winterberg, Mandy L. Ford
Publikováno v:
Current Opinion in Organ Transplantation. 22:22-28
Purpose of review Altered differentiation and activation of T-cell subsets occur in patients with chronic kidney disease (CKD), but the impact on graft rejection and protective immunity during transplantation are not fully understood. Recent findings