Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Crystal L Mackall"'
Autor:
Robert C. Jones, Surya Nagaraja, Ansuman T. Satpathy, Michelle Monje, Zinaida Good, Elena Sotillo, Howard Y. Chang, Peng Xu, Hima Anbunathan, Evan W. Weber, Crystal L. Mackall, Rachel C. Lynn, Charles F. A. de Bourcy, David Gennert, John Lattin, Jeffrey M. Granja, Robbie G. Majzner, Victor Tieu, Stephen R. Quake
Publikováno v:
Nature
Chimeric antigen receptor (CAR) T cells mediate anti-tumour effects in a small subset of patients with cancer1-3, but dysfunction due to T cell exhaustion is an important barrier to progress4-6. To investigate the biology of exhaustion in human T cel
Autor:
Amin Aalipour, Juliane K. Lohmeyer, Xuhuai Ji, Robert S. Negrin, Kristina Maas-Bauer, Arielle S. Wenokur, Maite Alvarez, Federico Simonetta, Crystal L. Mackall, Toshihito Hirai, Jeanette Baker, Samuel T. Haile
Publikováno v:
Clin Cancer Res
Purpose: The development of allogeneic chimeric antigen receptor (CAR) T-cell therapies for off-the-shelf use is a major goal that faces two main immunologic challenges, namely the risk of graft-versus-host disease (GvHD) induction by the transferred
Autor:
Kevin J. Curran, Nirali N. Shah, Steven A. Rosenberg, Marco L. Davila, Roisin E. O'Cearbhaill, Gary E. Archer, Jean Yuh Tang, Crystal L. Mackall, Richard P. Junghans, Michel Sadelain, Lisa Duffy, Kenneth Cornetta, Renier J. Brentjens, Rosie Kaplan, Hans-Peter Kiem, Steven A. Feldman, Isabelle Riviere, Cindy Delbrook, James N. Kochenderfer
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 10, Iss, Pp 371-378 (2018)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Replication-competent retrovirus (RCR) is a safety concern for individuals treated with retroviral gene therapy. RCR detection assays are used to detect RCR in manufactured vector, transduced cell products infused into research subjects, and in the r
Autor:
Steven A. Feldman, Kara L. Davis, John H. Baird, Robert Lowsky, Rachel C. Lynn, Magali Bazzano, Judith A. Shizuru, Matthew J. Frank, Surbhi Sidana, Maria Caterina Rotiroti, Maria Iglesias, Sean Mackay, Sally Arai, Bita Sahaf, Shabnum Patel, Nirali N. Shah, Laura Johnston, Jay Y. Spiegel, Jing Zhou, Juliana Craig, Robert S. Negrin, Robbie G. Majzner, Andrew R. Rezvani, Zach Ehlinger, Ilan R. Kirsch, Parveen Shiraz, Chelsea D. Mullins, Michael G. Ozawa, Nikolaos Gkitsas, Crystal L. Mackall, Terry J. Fry, Warren D. Reynolds, Yasodha Natkunam, Sneha Ramakrishna, Scott J. Bornheimer, Allison P. Jacob, Lori Muffly, Jean Oak, Haiying Qin, Katherine A. Kong, Wen-Kai Weng, Everett Meyer, Nasheed Hossain, John S. Tamaresis, Sheren F. Younes, David B. Miklos, Liora M. Schultz, Eric J Yang, Harshini Chinnasamy
Publikováno v:
Nature Medicine
Despite impressive progress, more than 50% of patients treated with CD19-targeting chimeric antigen receptor T cells (CAR19) experience progressive disease. Ten of 16 patients with large B cell lymphoma (LBCL) with progressive disease after CAR19 tre
Autor:
Anthony A. Fodor, Erin F. Brooks, Crystal L. Mackall, Farnaz Fouladi, Matthew T. Buckley, Robert S. Negrin, Bita Sahaf, Andrew R. Rezvani, Courtney Greene, Ekaterina Tkachenko, David B. Miklos, Sally Arai, Haley Hedlin, Ami S. Bhatt, Tessa M. Andermann, Fiona B. Tamburini
Publikováno v:
Transplant Cell Ther
Alterations of the gut microbiota after allogeneic hematopoietic cell transplantation (allo-HCT) are a key factor in the development of transplant-related complications such as graft-versus-host disease (GVHD). Interventions that preserve the gut mic
Autor:
Shaurya Dhingra, Samuel H. Cheshier, Sabine Mueller, Stéphanie Puget, Marcel Kool, Siddhartha Mitra, Derek Yecies, Olivier Delattre, Michael C. Frühwald, Johanna Theruvath, Christopher Mount, Robbie G. Majzner, Sakina Zaidi, Didier Surdez, Louai Labanieh, Daniel Williamson, Poul H. Sorensen, Amaury Leruste, Franck Bourdeaut, Claus Moritz Graef, Alberto Delaidelli, Pascal Johann, Crystal L. Mackall, Michelle Monje, Elena Sotillo, Stefan M. Pfister, Sabine Heitzeneder, Peng Xu, Martin Hasselblatt, Martina Finetti
Publikováno v:
Nat Med
Atypical teratoid/rhabdoid tumors (ATRTs) typically arise in the central nervous system (CNS) of children under 3 years of age. Despite intensive multimodal therapy (surgery, chemotherapy and, if age permits, radiotherapy), median survival is 17 mont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec562df3042d0e34b5ccbb1718d69d97
https://europepmc.org/articles/PMC7992505/
https://europepmc.org/articles/PMC7992505/
Autor:
Nirali N. Shah, Mark J. Roth, Haneen Shalabi, Amita Kulshreshtha, Constance M. Yuan, Dalia A. Salem, Crystal L. Mackall, Alina Dulau-Florea, Terry J. Fry, Maryalice Stetler-Stevenson, Armando C. Filie, Alan S. Wayne, Daniel W. Lee, Joanne Derdak, Bonnie Yates, Gaurav K. Gupta, Cindy Delbrook
Publikováno v:
Pediatr Blood Cancer
Background Accurate disease detection is integral to risk stratification in B-cell acute lymphoblastic leukemia (ALL). The gold standard used to evaluate response in the United States includes morphologic evaluation and minimal residual disease (MRD)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c89c2d44636318636e59063161f9bd
https://europepmc.org/articles/PMC7036332/
https://europepmc.org/articles/PMC7036332/
Autor:
Zinaida Good, Crystal L. Mackall, Dorota Klysz, Yanyan Qi, John Lattin, Louai Labanieh, Katalin Sandor, Bence Daniel, Howard Y. Chang, Peng Xu, Ansuman T. Satpathy, Thomas J. Wandless, Panayiotis Vandris, Elena Sotillo, Meena Malipatlolla, Ling-chun Chen, Andrew J. Gentles, Rachel C. Lynn, Sabine Heitzeneder, Hima Anbunathan, Evan W. Weber, Kevin R. Parker, Malek Bashti, Snehit Prabhu, Robbie G. Majzner, Julia A. Belk
Publikováno v:
Science (New York, N.Y.)
CAR-T cells rest to get back in the race Chimeric antigen receptor (CAR)–T cells, which are engineered to target specific tumor antigens, are increasingly used as an immunotherapy. CAR-T cells have shown promising results in patients, particularly
Autor:
Katherine K. Matthay, Crystal L. Mackall, Phillip Barnette, Richard B. Womer, Steven G. DuBois, Douglas S. Hawkins, Elizabeth Sinclair, Stephen L. Lessnick, Richard Gorlick, Katherine A. Janeway, Jeremy V. Edwards, Donald A. Barkauskas, Kieuhoa T. Vo, Holcombe E. Grier, C. Lorrie Epling, Mark Krailo, Elizabeth McIlvaine
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research, vol 22, iss 14
Purpose: Flow cytometry and RT-PCR can detect occult Ewing sarcoma cells in the blood and bone marrow. These techniques were used to evaluate the prognostic significance of micrometastatic disease in Ewing sarcoma. Experimental Design: Newly diagnose
Autor:
Jack F. Shern, Meera Murgai, Terry J. Fry, Alec J. Walker, M. Eric Kohler, Rimas J. Orentas, Crystal L. Mackall, Maria Ingaramo, Rosandra N. Kaplan, Kelsey Wanhainen, Adrienne H. Long, Waleed Haso, Jillian P. Smith, George H. Patterson, Vikas R Venkateshwara
Publikováno v:
Nature medicine
Chimeric antigen receptors (CARs) targeting CD19 have mediated dramatic antitumor responses in hematologic malignancies, but tumor regression has rarely occurred using CARs targeting other antigens. It remains unknown whether the impressive effects o