Zobrazeno 21 - 30
of 30
pro vyhledávání: '"Crystal L Mackall"'
Autor:
Robert Korngold, Claude Sportes, Michel Morre, Thomas A. Fleisher, Hua Zhang, Sarfraz Memon, Crystal L. Mackall, Terry J. Fry, Rebecca Babb, Catherine Chow, Renaud Buffet, Kevin S. Chua, Julie Engels, Robert J. Amato, Ronald E. Gress, David Venzon, Andrew L. Pecora, Margaret R. Brown, Frances T. Hakim, Michael Krumlauf
Publikováno v:
The Journal of Experimental Medicine
Interleukin-7 (IL-7) is a homeostatic cytokine for resting T cells with increasing serum and tissue levels during T cell depletion. In preclinical studies, IL-7 therapy exerts marked stimulating effects on T cell immune reconstitution in mice and pri
Autor:
Linda T. Vahdat, Meera Murgai, Rosandra N. Kaplan, Amber J. Giles, Steven L. Highfill, Caitlin M. Reid, David Lyden, Crystal L. Mackall, Justin Evans, Leonard H. Wexler, Miki Kasai, Yorleny Vicioso
Publikováno v:
Cancer research. 76(6)
Metastatic tumors have been shown to establish microenvironments in distant tissues that are permissive to disseminated tumor cells. Hematopoietic cells contribute to this microenvironment, yet the precise initiating events responsible for establishi
Autor:
Steven A. Rosenberg, Constance M. Yuan, Marianna Sabatino, Terry J. Fry, Ling Zhang, Hua Zhang, Crystal L. Mackall, Rimas J. Orentas, Alan S. Wayne, Steven A. Feldman, Maryalice Stetler-Stevenson, James N. Kochenderfer, Dave Stroncek, Cindy Delbrook, Nick Tschernia, Nirali N. Shah, Seth M. Steinberg, Daniel W. Lee, Yongzhi K Cui
Publikováno v:
Lancet (London, England). 385(9967)
Summary Background Chimeric antigen receptor (CAR) modified T cells targeting CD19 have shown activity in case series of patients with acute and chronic lymphocytic leukaemia and B-cell lymphomas, but feasibility, toxicity, and response rates of cons
Autor:
Warren J. Leonard, Terry J. Fry, John F. Kelly, Amin Al-Shami, Pamela L. Schwartzberg, Crystal L. Mackall, Akhilesh Pandey, Rosanne Spolski
Publikováno v:
The Journal of Experimental Medicine
Thymic stromal lymphopoietin (TSLP) signals via a receptor comprising the interleukin (IL)-7 receptor alpha chain and a distinctive subunit, TSLP receptor (TSLPR), which is most related to the common cytokine receptor gamma chain, gamma(c). We have g
IL-7 plays many essential roles in human health and disease. Congenital deficiencies in IL-7 signaling result in profound immunodeficiency, polymorphisms in IL7Rα modulate susceptibility to autoimmune disease, and acquired somatic activating mutatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6fe176de09be6cc688057458e2ac728f
https://europepmc.org/articles/PMC3358500/
https://europepmc.org/articles/PMC3358500/
Publikováno v:
Nat Rev Immunol
Interleukin-7 (IL-7) is required for T cell development and for maintaining and restoring homeostasis of mature T cells. IL-7 is a limiting resource under normal conditions, but it accumulates during lymphopaenia, leading to increased T cell prolifer
Autor:
Young K. Song, Rimas J. Orentas, Crystal L. Mackall, Glenn Merlino, Qing Rong Chen, Joanna L. Meadors, Maria Tsokos, Javed Khan, Yonghzi Cui
Publikováno v:
Pediatric bloodcancer. 57(6)
Background Immunotherapies targeting cellular immunity are currently approved for treatment of melanoma, renal cell carcinoma, and prostate cancer. Studies on the immunogenicity and immune responsiveness of pediatric tumors are limited, therefore, it
Autor:
Seth M. Steinberg, Thomas A. Fleisher, Claude Sportes, Margaret R. Brown, Pierre Noel, Rebecca Babb, Andrew L. Pecora, Irina Maric, Robert J. Amato, Frances T. Hakim, Maryalice Stetler-Stevenson, Renaud Buffet, Julie Engel, Michel Morre, Catherine Chow, Ronald E. Gress, Michael Krumlauf, Crystal L. Mackall
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 16(2)
Purpose: Interleukin-7 (IL-7) has critical and nonredundant roles in T-cell development, hematopoiesis, and postdevelopmental immune functions as a prototypic homeostatic cytokine. Based on a large body of preclinical evidence, it may have multiple t
Autor:
Lien T. Ngo, Michel Morre, Susan L. Schwarz, Terry J. Fry, Maryalice Stetler-Stevenson, Kathleen E. Morton, Steven A. Rosenberg, Renaud Buffet, Mojgan Ahmadzadeh, Ronald E. Gress, Claude Sportes, Crystal L. Mackall, Sharon Mavroukakis
Publikováno v:
Journal of immunotherapy (Hagerstown, Md. : 1997). 29(3)
Lymphopenia is a serious consequence of HIV infection and the administration of cancer chemotherapeutic agents. Although growth factors can be administered to patients to increase circulating neutrophils, there is no effective method to stimulate CD8
Autor:
Catherine Chow, Claude Kasten-Sportes, Rosemarie Cepeda, Elizabeth C. Jones, Barbara A. Vance, Jeanne Odom, Sarfraz Memon, Ronald E. Gress, Barbara L. Christensen, Frances T. Hakim, Crystal L. Mackall
Homeostatic regulation of T cells involves an ongoing balance of new T cell generation, peripheral expansion, and turnover. The recovery of T cells when this balance is disrupted provides insight into the mechanisms that govern homeostasis. In a long
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b718ae23debd154172354d6fa38de9e6
https://europepmc.org/articles/PMC1064981/
https://europepmc.org/articles/PMC1064981/
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