Zobrazeno 1 - 10
of 823
pro vyhledávání: '"11"'
Autor:
Ke Li, Jia-Xing Wang, Nirmal K. Banda, Ang Li, Na Wang, Teng-Yue Diao, Dan Liu, Ning Ma, Jia-Yu Liu, Zongfang Li, Conrad A. Farrar, Rafael Bayarri-Olmos, Cui Qiang, Wuding Zhou, Xiao Yang, Li Xue, Weiju Wu, Peter Garred, Baojun Zhang, Kun-Yi Wu
Publikováno v:
Wang, N, Wu, W, Qiang, C, Ma, N, Wu, K, Liu, D, Wang, J X, Yang, X, Xue, L, Diao, T Y, Liu, J Y, Li, A, Zhang, B, Li, Z F, Farrar, C A, Banda, N K, Bayarri-Olmos, R, Garred, P, Zhou, W & Li, K 2021, ' Protective Role of Collectin 11 in a Mouse Model of Rheumatoid Arthritis ', Arthritis and Rheumatology, vol. 73, no. 8, pp. 1430-1440 . https://doi.org/10.1002/art.41696
Arthritis Rheumatol
Wang, N, Wu, W, Qiang, C, Ma, N, Wu, K, Liu, D, Wang, J, Yang, X, Xue, L, Diao, T, Liu, J, Li, A, Zhang, B, Li, Z, Farrar, C A, Banda, N K, Bayarri-olmos, R, Garred, P, Zhou, W & Li, K 2021, ' Protective Role of Collectin 11 in a Mouse Model of Rheumatoid Arthritis ', Arthritis and Rheumatology, vol. 73, no. 8, pp. 1430-1440 . https://doi.org/10.1002/art.41696
Arthritis Rheumatol
Wang, N, Wu, W, Qiang, C, Ma, N, Wu, K, Liu, D, Wang, J, Yang, X, Xue, L, Diao, T, Liu, J, Li, A, Zhang, B, Li, Z, Farrar, C A, Banda, N K, Bayarri-olmos, R, Garred, P, Zhou, W & Li, K 2021, ' Protective Role of Collectin 11 in a Mouse Model of Rheumatoid Arthritis ', Arthritis and Rheumatology, vol. 73, no. 8, pp. 1430-1440 . https://doi.org/10.1002/art.41696
Objective: Collectin 11 (CL-11) is a soluble C-type lectin, a mediator of innate immunity. Its role in autoimmune disorders is unknown. We undertook this study to determine the role of CL-11 in a mouse model of rheumatoid arthritis (RA). Methods: A m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fea9e9ad849ed40dc058b9cf42746c85
https://curis.ku.dk/portal/da/publications/protective-role-of-collectin-11-in-a-mouse-model-of-rheumatoid-arthritis(7db555d1-70d0-4c84-a9c7-305f761d2824).html
https://curis.ku.dk/portal/da/publications/protective-role-of-collectin-11-in-a-mouse-model-of-rheumatoid-arthritis(7db555d1-70d0-4c84-a9c7-305f761d2824).html
Autor:
Andreja Škofljanec, Barbara B. Warner, Daniel J. Wegner, Dorothy K. Grange, F. Munell, Robert Steinfeld, James W. Collins, Ekkehard Wilichowski, Alan Pestronk, Mattia Bosio, Stephan Ossowski, Jennifer A. Wambach, Tobias B. Haack, Georg M. Stettner, Robert E. Schmidt, Aleš Maver, Karin Writzl, F. Sessions Cole, Dustin Baldridge, Tim M. Strom, Marwan Shinawi, Robin Troxell, Bader Alhaddad
Publikováno v:
Human Mutation. 38:1477-1484
Biallelic GLDN mutations have recently been identified among infants with lethal congenital contracture syndrome 11 (LCCS11). GLDN encodes gliomedin, a protein required for the formation of the nodes of Ranvier and development of the human peripheral
Autor:
Hans P. Kiener, Esther Jimenez-Boj, Josef S Smolen, David M. Lee, Birgit Niederreiter, Michael B. Brenner
Publikováno v:
Arthritis & Rheumatism. 60:1305-1310
Rheumatoid arthritis (RA) is a chronic inflammatory disease localized in the synovium that causes joint destruction (1). The normal synovium forms a thin membrane composed of fibroblast-like synoviocytes (FLS) of mesenchymal origin located between th
Autor:
Jennie Olofsson, Peter Lönnerberg, Caroline Ingre, Elena Rodriguez-Vieitez, Inci Sevval Aksoylu, Caroline Mijnsbergen, Manuela Lehmann, Jan H. Veldink, Inti von Gohren Antequera, Albert C. Ludolph, Anna Szczepińska, Stefan Wouters, Mathias Uhlén, Ulf Kläppe, Eleonora Aronica, Hermieneke Vergunst-Bosch, Anna Månberg, Julia Remnestål, Sebastian A. Lewandowski, Lwaki Ebarasi, Peter Nilsson, Aylin Domaniku, Robert A. Harris, Nathan G. Skene, Jasper J. Anink, Joke De Vocht, Eva Hedlund, Annemarie Hübers, Koen Poesen, Philip Van Damme, Marta Trusohamn, Jonathan D. Gilthorpe, Maxim De Schaepdryver, Folkert Sanders
Publikováno v:
Nature medicine, 27(4), 640-646. Nature Publishing Group
Nat Med
Nature medicine 27(4), 640-646 (2021). doi:10.1038/s41591-021-01295-9
Nat Med
Nature medicine 27(4), 640-646 (2021). doi:10.1038/s41591-021-01295-9
Apart from well-defined factors in neuronal cells1, only a few reports consider that the variability of sporadic amyotrophic lateral sclerosis (ALS) progression can depend on less-defined contributions from glia2,3 and blood vessels4. In this study w
Autor:
Richard J.H. Smith, David J. Kavanagh, Fadi Fakhouri, Vivette D. D'Agati, Véronique Frémeaux-Bacchi, Gerald B. Appel, Giuseppe Remuzzi, Carla M. Nester, Santiago Rodríguez de Córdoba, Sanjeev Sethi, Mihály Józsi, Marina Noris, Matthew C. Pickering, Johan van der Vlag, Peter F. Zipfel, Anna M. Blom, H. Terence Cook, John D. Lambris
Publikováno v:
Nature Reviews. Nephrology, 15, 129-143
Nature Reviews. Nephrology, 15, 3, pp. 129-143
Nature Reviews. Nephrology, 15, 3, pp. 129-143
Item does not contain fulltext The C3 glomerulopathies are a group of rare kidney diseases characterized by complement dysregulation occurring in the fluid phase and in the glomerular microenvironment, which results in prominent complement C3 deposit
Autor:
Benjamin G. Neel, Mitchell J. Geer, Kwok-Kin Wong, Brian Diskin, Takamitsu Hattori, Paolo Mita, Kai Wen Teng, Connor Foster, Joshua Leinwand, Carmine Fedele, Akiko Koide, Ting Chen, Wei Wang, Shohei Koide, Shuai Li, Kwan Ho Tang, Yubao Wang, David H. Peng, Jiehui Deng, Hao Ran, Igor Dolgalev, George Miller, Ugur Ozerdem
Publikováno v:
The Journal of Experimental Medicine
G12C inhibitors (G12C-Is) have significant but limited efficacy in KRAS-mutant malignancies, mostly due to “adaptive resistance.” Combining SHP2 inhibitor (SHP2-I) with G12C-I abrogates adaptive resistance; evokes beneficial, tumor-specific chang
Autor:
Wei Liu, Wen-Mei Yu, Mignon L. Loh, Jing Zhang, Cheng-Kui Qu, Rebecca J. Chan, Kevin D. Bunting, Zheng Zhang
Publikováno v:
Leukemia
Leukemia, vol 31, iss 6
Leukemia, vol 31, iss 6
Activating mutations, such as E76K and D61Y, in PTPN11 (SHP2), a protein tyrosine phosphatase implicated in multiple cell signaling processes, are associated with 35% of patients with juvenile myelomonocytic leukemia (JMML), an aggressive childhood m
Autor:
Alan Sher, Sheena Ruzive, Alessandro Sette, Cecilia S. Lindestam Arlehamn, Robert J. Wilkinson, Daniel L. Barber, Catherine Riou, Elsa Du Bruyn
Publikováno v:
Mucosal immunology
Recent data from mice and non-human primate models of tuberculosis suggested that CD153, a TNF super family member, plays an important role in Mycobacterium tuberculosis (Mtb) control. However, this molecule has not been comprehensively evaluated in
Autor:
Jessica G. Borger, Benjamin G Dewals, Daniel M. Davis, Sheila Brown, Alexander T. Phythian-Adams, Annette M. Dougall, Adam N.R. Cartwright, Cecilia Johansson, Ruud H. P. Wilbers, Rachel J. Lundie, Peter C. Cook, Lucy H. Jackson-Jones, Franca Ronchese, Andrew S. MacDonald, Lauren M. Webb, Lisa M. Connor
Publikováno v:
The EMBO Journal 36 (2017) 16
Webb, L M, Lundie, R J, Borger, J G, Brown, S, Connor, L M, Cartwright, A N R, Dougall, A M, Wilbers, R, Cook, P, Jackson-Jones, L, Phythian-Adams, A T, Johansson, C, Davis, D M, Dewals, B G, Ronchese, F & MacDonald, A 2017, ' Type I interferon is required for T helper (Th) 2 induction by dendritic cells ', EMBO Journal . https://doi.org/10.15252/embj.201695345
The EMBO Journal, 36(16), 2404-2418
The EMBO Journal
Webb, L, Lundie, R J, Borger, J G, Brown, S, Connor, L M, Cartwright, A, Dougall, A M, Wilbers, R H P, Cook, P, Jackson-Jones, L H, Phythian-Adams, A, Johansson, C, Davis, D M, Dewals, B G, Ronchese, F & MacDonald, A 2017, ' Type I interferon is required for T helper (Th) 2 induction by dendritic cells ', The EMBO Journal, vol. 36, no. 16, pp. 2404-2418 . https://doi.org/10.15252/embj.201695345
Webb, L M, Lundie, R J, Borger, J G, Brown, S, Connor, L M, Cartwright, A N R, Dougall, A M, Wilbers, R, Cook, P, Jackson-Jones, L, Phythian-Adams, A T, Johansson, C, Davis, D M, Dewals, B G, Ronchese, F & MacDonald, A 2017, ' Type I interferon is required for T helper (Th) 2 induction by dendritic cells ', EMBO Journal . https://doi.org/10.15252/embj.201695345
The EMBO Journal, 36(16), 2404-2418
The EMBO Journal
Webb, L, Lundie, R J, Borger, J G, Brown, S, Connor, L M, Cartwright, A, Dougall, A M, Wilbers, R H P, Cook, P, Jackson-Jones, L H, Phythian-Adams, A, Johansson, C, Davis, D M, Dewals, B G, Ronchese, F & MacDonald, A 2017, ' Type I interferon is required for T helper (Th) 2 induction by dendritic cells ', The EMBO Journal, vol. 36, no. 16, pp. 2404-2418 . https://doi.org/10.15252/embj.201695345
Type 2 inflammation is a defining feature of infection with parasitic worms(helminths), as well as being responsible for widespread suffering in allergies.However, the precise mechanisms involved in T helper (Th) 2 polarization bydendritic cells (DCs
Autor:
Katie J. Ewer, Tom Ford, Jill Gilmour, Nicola Winstone, Len Dally, Claire Wenden, Josephine H. Cox, Alison Mbekeani, Merribeth Morin, Adrian V. S. Hill
Publikováno v:
Vaccine
Ex vivo functional immunoassays such as ELISpot and intracellular cytokine staining (ICS) by flow cytometry are crucial tools in vaccine development both in the identification of novel immunogenic targets and in the immunological assessment of sample