Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Crystal L Mackall"'
Autor:
Robert C. Jones, Surya Nagaraja, Ansuman T. Satpathy, Michelle Monje, Zinaida Good, Elena Sotillo, Howard Y. Chang, Peng Xu, Hima Anbunathan, Evan W. Weber, Crystal L. Mackall, Rachel C. Lynn, Charles F. A. de Bourcy, David Gennert, John Lattin, Jeffrey M. Granja, Robbie G. Majzner, Victor Tieu, Stephen R. Quake
Publikováno v:
Nature
Chimeric antigen receptor (CAR) T cells mediate anti-tumour effects in a small subset of patients with cancer1-3, but dysfunction due to T cell exhaustion is an important barrier to progress4-6. To investigate the biology of exhaustion in human T cel
Autor:
Lauren Little, Nirali N. Shah, Crystal L. Mackall, Haneen Shalabi, Daniel W. Lee, Seth M. Steinberg, John C. Molina, Bonnie Yates
Publikováno v:
Transplant Cell Ther
Hematopoietic stem cell transplantation (HSCT) may be used to consolidate chimeric antigen receptor (CAR) T cell therapy-induced remissions for patients with relapsed/refractory B cell acute lymphoblastic leukemia (B-ALL), but little is known about t
Autor:
Siddhartha Mitra, Zhongyu Zhu, Anandani Nellan, Johanna Theruvath, Ezio Bonvini, Skyler P. Rietberg, Ravindra Majeti, Christopher Rota, Sabine Heitzeneder, Crystal L. Mackall, Elena Sotillo, Yongzhi Cui, Peng Xu, Alla Sekunova, Christopher Mount, Alberto Delaidelli, John M. Maris, Daniel W. Lee, Michelle Monje, Brad St. Croix, Robbie G. Majzner, Dimiter S. Dimitrov, Miles H. Linde, Poul H. Sorensen, Martha Quezado, Louai Labanieh, Rimas J. Orentas
Publikováno v:
Clin Cancer Res
Purpose: Patients with relapsed pediatric solid tumors and CNS malignancies have few therapeutic options and frequently die of their disease. Chimeric antigen receptor (CAR) T cells have shown tremendous success in treating relapsed pediatric acute l
Autor:
Shaurya Dhingra, Samuel H. Cheshier, Sabine Mueller, Stéphanie Puget, Marcel Kool, Siddhartha Mitra, Derek Yecies, Olivier Delattre, Michael C. Frühwald, Johanna Theruvath, Christopher Mount, Robbie G. Majzner, Sakina Zaidi, Didier Surdez, Louai Labanieh, Daniel Williamson, Poul H. Sorensen, Amaury Leruste, Franck Bourdeaut, Claus Moritz Graef, Alberto Delaidelli, Pascal Johann, Crystal L. Mackall, Michelle Monje, Elena Sotillo, Stefan M. Pfister, Sabine Heitzeneder, Peng Xu, Martin Hasselblatt, Martina Finetti
Publikováno v:
Nat Med
Atypical teratoid/rhabdoid tumors (ATRTs) typically arise in the central nervous system (CNS) of children under 3 years of age. Despite intensive multimodal therapy (surgery, chemotherapy and, if age permits, radiotherapy), median survival is 17 mont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec562df3042d0e34b5ccbb1718d69d97
https://europepmc.org/articles/PMC7992505/
https://europepmc.org/articles/PMC7992505/
Autor:
Zinaida Good, Crystal L. Mackall, Dorota Klysz, Yanyan Qi, John Lattin, Louai Labanieh, Katalin Sandor, Bence Daniel, Howard Y. Chang, Peng Xu, Ansuman T. Satpathy, Thomas J. Wandless, Panayiotis Vandris, Elena Sotillo, Meena Malipatlolla, Ling-chun Chen, Andrew J. Gentles, Rachel C. Lynn, Sabine Heitzeneder, Hima Anbunathan, Evan W. Weber, Kevin R. Parker, Malek Bashti, Snehit Prabhu, Robbie G. Majzner, Julia A. Belk
Publikováno v:
Science (New York, N.Y.)
CAR-T cells rest to get back in the race Chimeric antigen receptor (CAR)–T cells, which are engineered to target specific tumor antigens, are increasingly used as an immunotherapy. CAR-T cells have shown promising results in patients, particularly
Autor:
Adrienne H. Long, Rimas J. Orentas, Steven L. Highfill, Jillian P. Smith, Sneha Ramakrishna, Crystal L. Mackall, Alec J. Walker, Susana Galli, Rana El-Etriby, Maria Tsokos, Yongzhi Cui
Publikováno v:
Cancer Immunology Research. 4:869-880
Genetically engineered T cells expressing CD19-specific chimeric antigen receptors (CAR) have shown impressive activity against B-cell malignancies, and preliminary results suggest that T cells expressing a first-generation disialoganglioside (GD2)-s
Autor:
Jack F. Shern, Meera Murgai, Terry J. Fry, Alec J. Walker, M. Eric Kohler, Rimas J. Orentas, Crystal L. Mackall, Maria Ingaramo, Rosandra N. Kaplan, Kelsey Wanhainen, Adrienne H. Long, Waleed Haso, Jillian P. Smith, George H. Patterson, Vikas R Venkateshwara
Publikováno v:
Nature medicine
Chimeric antigen receptors (CARs) targeting CD19 have mediated dramatic antitumor responses in hematologic malignancies, but tumor regression has rarely occurred using CARs targeting other antigens. It remains unknown whether the impressive effects o
Autor:
Terry J. Fry, Crystal L. Mackall
Publikováno v:
Hematology Am Soc Hematol Educ Program
Substantial progress has been made in the treatment of precursor B-cell acute lymphoblastic leukemia (B-ALL), but recurrent disease remains a leading cause of death in children due to cancer and outcomes for adults with B-ALL remain poor. Recently, c
Autor:
Tasha Lin, Marianna Sabatino, Daniel W. Lee, Barbara Tumaini, Luciano Castiello, Crystal L. Mackall, David F. Stroncek, Alan S. Wayne
Publikováno v:
Cytotherapy. 15:1406-1415
Background aims Adoptive immunotherapy with the use of chimeric antigen receptor (CAR)-engineered T cells specific for CD19 has shown promising results for the treatment of B-cell lymphomas and leukemia. This therapy involves the transduction of auto
Autor:
Jiaqiang Ren, Hanh Khuu, Minh Tran, Crystal L. Mackall, Sue Ellen Frodigh, Melinda S. Merchant, David F. Stroncek, Daniel W. Lee, Marianna Sabatino
Background aims Autologous chimeric antigen receptor (CAR) T-cell therapies have shown promising clinical outcomes, but T-cell yields have been variable. CD19- and GD2-CAR T-cell manufacturing records were reviewed to identify sources of variability.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c13f850306b0fc264f7e656225e291c
https://europepmc.org/articles/PMC4898642/
https://europepmc.org/articles/PMC4898642/