Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Crystal L Mackall"'
Autor:
Adrienne H. Long, Rimas J. Orentas, Steven L. Highfill, Jillian P. Smith, Sneha Ramakrishna, Crystal L. Mackall, Alec J. Walker, Susana Galli, Rana El-Etriby, Maria Tsokos, Yongzhi Cui
Publikováno v:
Cancer Immunology Research. 4:869-880
Genetically engineered T cells expressing CD19-specific chimeric antigen receptors (CAR) have shown impressive activity against B-cell malignancies, and preliminary results suggest that T cells expressing a first-generation disialoganglioside (GD2)-s
Autor:
Jiaqiang Ren, Hanh Khuu, Minh Tran, Crystal L. Mackall, Sue Ellen Frodigh, Melinda S. Merchant, David F. Stroncek, Daniel W. Lee, Marianna Sabatino
Background aims Autologous chimeric antigen receptor (CAR) T-cell therapies have shown promising clinical outcomes, but T-cell yields have been variable. CD19- and GD2-CAR T-cell manufacturing records were reviewed to identify sources of variability.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c13f850306b0fc264f7e656225e291c
https://europepmc.org/articles/PMC4898642/
https://europepmc.org/articles/PMC4898642/
Autor:
Bradford J. Wood, Donna Bernstein, Martha Amoako, Hua Zhang, Thomas A. Fleisher, Marianna Sabatino, Matthew Wright, Crystal L. Mackall, Seth M. Steinberg, Michel Morre, Dave Stroncek, Kristin Baird, Melinda S. Merchant, Aradhana M. Venkatasan
Publikováno v:
Clin Cancer Res
Purpose: Patients with metastatic or relapsed pediatric sarcomas receive cytotoxic regimens that induce high remission rates associated with profound lymphocyte depletion, but ultimately few survive long term. We administered adjuvant immunotherapy t
Publikováno v:
Pediatric Clinics of North America. 57:83-96
One major advance in T-cell-based immunotherapy in the last 20 years has been the molecular definition of numerous viral and tumor antigens. Adoptive T-cell transfer has shown definite clinical benefit in the prophylaxis and treatment of viral infect
Autor:
Steven A. Rosenberg, Constance M. Yuan, Marianna Sabatino, Terry J. Fry, Ling Zhang, Hua Zhang, Crystal L. Mackall, Rimas J. Orentas, Alan S. Wayne, Steven A. Feldman, Maryalice Stetler-Stevenson, James N. Kochenderfer, Dave Stroncek, Cindy Delbrook, Nick Tschernia, Nirali N. Shah, Seth M. Steinberg, Daniel W. Lee, Yongzhi K Cui
Publikováno v:
Lancet (London, England). 385(9967)
Summary Background Chimeric antigen receptor (CAR) modified T cells targeting CD19 have shown activity in case series of patients with acute and chronic lymphocytic leukaemia and B-cell lymphomas, but feasibility, toxicity, and response rates of cons
Autor:
Crystal L. Mackall, Edwin M. Horwitz, Jennifer L. Leddon, Kellie B. Haworth, Chun-Yu Chen, Timothy P. Cripe
Publikováno v:
Pediatric bloodcancer. 62(4)
After decades of unfulfilled promise, immunotherapies for cancer have finally reached a tipping point, with several FDA approved products now on the market and many more showing promise in both adult and pediatric clinical trials. Tumor cell expressi