Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Crystal L Mackall"'
Autor:
Johanna Theruvath, Marie Menard, Benjamin A. H. Smith, Miles H. Linde, Garry L. Coles, Guillermo Nicolas Dalton, Wei Wu, Louise Kiru, Alberto Delaidelli, Elena Sotillo, John L. Silberstein, Anna C. Geraghty, Allison Banuelos, Molly Thomas Radosevich, Shaurya Dhingra, Sabine Heitzeneder, Aidan Tousley, John Lattin, Peng Xu, Jing Huang, Nicole Nasholm, Andy He, Tracy C. Kuo, Emma R. B. Sangalang, Jaume Pons, Amira Barkal, Rachel E. Brewer, Kristopher D. Marjon, Jose G. Vilches-Moure, Payton L. Marshall, Ricardo Fernandes, Michelle Monje, Jennifer R. Cochran, Poul H. Sorensen, Heike E. Daldrup-Link, Irving L. Weissman, Julien Sage, Ravindra Majeti, Carolyn R. Bertozzi, William A. Weiss, Crystal L. Mackall, Robbie G. Majzner
Publikováno v:
Nature medicine, vol 28, iss 2
Nat Med
Nat Med
The disialoganglioside GD2 is overexpressed on several solid tumors, and monoclonal antibodies targeting GD2 have substantially improved outcomes for children with high-risk neuroblastoma. However, approximately 40% of patients with neuroblastoma sti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aad3910b686c28eafa24813f728551c
https://escholarship.org/uc/item/5nz6n240
https://escholarship.org/uc/item/5nz6n240
Autor:
Robert C. Jones, Surya Nagaraja, Ansuman T. Satpathy, Michelle Monje, Zinaida Good, Elena Sotillo, Howard Y. Chang, Peng Xu, Hima Anbunathan, Evan W. Weber, Crystal L. Mackall, Rachel C. Lynn, Charles F. A. de Bourcy, David Gennert, John Lattin, Jeffrey M. Granja, Robbie G. Majzner, Victor Tieu, Stephen R. Quake
Publikováno v:
Nature
Chimeric antigen receptor (CAR) T cells mediate anti-tumour effects in a small subset of patients with cancer1-3, but dysfunction due to T cell exhaustion is an important barrier to progress4-6. To investigate the biology of exhaustion in human T cel
Autor:
Siddhartha Mitra, Zhongyu Zhu, Anandani Nellan, Johanna Theruvath, Ezio Bonvini, Skyler P. Rietberg, Ravindra Majeti, Christopher Rota, Sabine Heitzeneder, Crystal L. Mackall, Elena Sotillo, Yongzhi Cui, Peng Xu, Alla Sekunova, Christopher Mount, Alberto Delaidelli, John M. Maris, Daniel W. Lee, Michelle Monje, Brad St. Croix, Robbie G. Majzner, Dimiter S. Dimitrov, Miles H. Linde, Poul H. Sorensen, Martha Quezado, Louai Labanieh, Rimas J. Orentas
Publikováno v:
Clin Cancer Res
Purpose: Patients with relapsed pediatric solid tumors and CNS malignancies have few therapeutic options and frequently die of their disease. Chimeric antigen receptor (CAR) T cells have shown tremendous success in treating relapsed pediatric acute l
Autor:
Zinaida Good, Crystal L. Mackall, Dorota Klysz, Yanyan Qi, John Lattin, Louai Labanieh, Katalin Sandor, Bence Daniel, Howard Y. Chang, Peng Xu, Ansuman T. Satpathy, Thomas J. Wandless, Panayiotis Vandris, Elena Sotillo, Meena Malipatlolla, Ling-chun Chen, Andrew J. Gentles, Rachel C. Lynn, Sabine Heitzeneder, Hima Anbunathan, Evan W. Weber, Kevin R. Parker, Malek Bashti, Snehit Prabhu, Robbie G. Majzner, Julia A. Belk
Publikováno v:
Science (New York, N.Y.)
CAR-T cells rest to get back in the race Chimeric antigen receptor (CAR)–T cells, which are engineered to target specific tumor antigens, are increasingly used as an immunotherapy. CAR-T cells have shown promising results in patients, particularly
Autor:
Adrienne H. Long, Rimas J. Orentas, Steven L. Highfill, Jillian P. Smith, Sneha Ramakrishna, Crystal L. Mackall, Alec J. Walker, Susana Galli, Rana El-Etriby, Maria Tsokos, Yongzhi Cui
Publikováno v:
Cancer Immunology Research. 4:869-880
Genetically engineered T cells expressing CD19-specific chimeric antigen receptors (CAR) have shown impressive activity against B-cell malignancies, and preliminary results suggest that T cells expressing a first-generation disialoganglioside (GD2)-s
Autor:
Jack F. Shern, Meera Murgai, Terry J. Fry, Alec J. Walker, M. Eric Kohler, Rimas J. Orentas, Crystal L. Mackall, Maria Ingaramo, Rosandra N. Kaplan, Kelsey Wanhainen, Adrienne H. Long, Waleed Haso, Jillian P. Smith, George H. Patterson, Vikas R Venkateshwara
Publikováno v:
Nature medicine
Chimeric antigen receptors (CARs) targeting CD19 have mediated dramatic antitumor responses in hematologic malignancies, but tumor regression has rarely occurred using CARs targeting other antigens. It remains unknown whether the impressive effects o
Autor:
Terry J. Fry, Jack H. Lai, Barry Jones, Iwona Woznica, Yuxin Liu, Najat Bouchkouj, Shannon M. Larabee, Haiying Qin, Crystal L. Mackall, Brynn B. Duncan, Steven L. Highfill, William W. Bachovchin, Wengen Wu, Youhua Li, Peng Zhao
Publikováno v:
Journal of Immunotherapy. 36:400-411
Current multimodality therapy consisting of surgery, chemotherapy and radiation will fail in approximately 40% of patients with pediatric sarcomas and results in substantial long-term morbidity in those who are cured. Immunotherapeutic regimens for t
Autor:
Sang M. Nguyen, Michael C. Jensen, Haiying Qin, Jack F. Shern, Daniel W. Lee, Haiyan Lei, Javed Khan, Kathryn M. Welp, Thomas J. Fountaine, Rebecca Gardner, Elad Jacoby, Berkley E. Gryder, Yinmeng Yang, Young K. Song, Terry J. Fry, Christopher D. Chien, Crystal L. Mackall, Alix E. Seif
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
Adoptive immunotherapy using chimeric antigen receptor (CAR) expressing T cells targeting the CD19 B lineage receptor has demonstrated marked success in relapsed pre-B-cell acute lymphoblastic leukaemia (ALL). Persisting CAR-T cells generate sustaine
Autor:
Marianna Sabatino, Curt I. Civin, Nga Voong, Yongzhi Cui, Sebastien Morisot, Crystal L. Mackall, Dave Stroncek, Bruce L. Levine, Hua Zhang, Alan S. Wayne
Publikováno v:
Journal of Immunotherapy. 34:187-195
Natural killer (NK) cells can mediate potent antitumor effects, but factors regulating the efficiency of tumor lysis remain unclear. Studies in allogeneic stem cell transplantation highlight an important role for killer cell immunoglobulin-like recep
Publikováno v:
Cancer Immunology, Immunotherapy. 58:1257-1264
Dendritic cells (DCs) serve as central regulators of adaptive immunity by presenting antigens and providing necessary co-signals. Environmental information received by the DCs determines the co-signals delivered to the responding adaptive cells and,