Zobrazeno 1 - 10
of 533
pro vyhledávání: '"11"'
Autor:
Jong Min Baek, Kwon-Ha Yoon, Yoon-Hee Cheon, Sung Chul Kwak, Hong Young Jun, Ju-Young Kim, Myeung Su Lee
Publikováno v:
Experimental and Molecular Medicine, Vol 50, Iss 4, Pp 1-18 (2018)
Experimental & Molecular Medicine
Experimental & Molecular Medicine
Claudins (Cldns) are well-established components of tight junctions (TJs) that play a pivotal role in the modulation of paracellular permeability. Several studies have explored the physiologic aspects of Cldn family members in bone metabolism. Howeve
Autor:
Minerva T. Garcia-Barrio, Michael Holinstat, Y. Eugene Chen, Daniel T. Eitzman, Wenying Liang, Reheman Adili, Jinjian Sun, Jintao Wang, Huilun Wang, Ziyi Chang, Wenting Hu, Haocheng Lu, Yanbo Fan, Tianqing Zhu, Jifeng Zhang
Objective— Mutations in Krüppel like factor-11 ( KLF11 ), a gene also known as maturity-onset diabetes mellitus of the young type 7, contribute to the development of diabetes mellitus. KLF11 has anti-inflammatory effects in endothelial cells and b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e1bc20dc383f644516844fc1d78ab1b
Autor:
Hans P. Kiener, Esther Jimenez-Boj, Josef S Smolen, David M. Lee, Birgit Niederreiter, Michael B. Brenner
Publikováno v:
Arthritis & Rheumatism. 60:1305-1310
Rheumatoid arthritis (RA) is a chronic inflammatory disease localized in the synovium that causes joint destruction (1). The normal synovium forms a thin membrane composed of fibroblast-like synoviocytes (FLS) of mesenchymal origin located between th
Autor:
Ryogo Shobatake, Maiko Takeda, Tomoko Uchiyama, Yasuhito Tanaka, Hajime Ohgushi, Yasuaki Tohma, Yoshiko Dohi, Shin Takasawa
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 18, Iss 11, p 2257 (2017)
International Journal of Molecular Sciences; Volume 18; Issue 11; Pages: 2257
International Journal of Molecular Sciences, Vol 18, Iss 11, p 2257 (2017)
International Journal of Molecular Sciences; Volume 18; Issue 11; Pages: 2257
The periosteum is a thin membrane that surrounds the outer surface of bones and participates in fracture healing. However, the molecular signals that trigger/initiate the periosteal reaction are not well established. We fractured the rat femoral bone
Autor:
Olga K. Weinberg, Rong Li, Ian S. Hitchcock, Daniel Yee, Elisabeth F. Heuston, Bethan Psaila, Stacie M. Anderson, Yotis A. Senis, Guanlin Wang, David M. Bodine, Nikolaos Sousos, Jennifer O'Sullivan, Irene Roberts, Dragana Milojkovic, Monica L. Calicchio, Lauren Murphy, Daniel Royston, Adam J. Mead, Alba Rodriguez-Meira, Supat Thongjuea, Deena Iskander
Publikováno v:
492.e8
Molecular Cell
Molecular Cell
Summary Myelofibrosis is a severe myeloproliferative neoplasm characterized by increased numbers of abnormal bone marrow megakaryocytes that induce fibrosis, destroying the hematopoietic microenvironment. To determine the cellular and molecular basis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1455e03e58d2996c2c8cc3c46622c8c1
http://hdl.handle.net/10044/1/84784
http://hdl.handle.net/10044/1/84784
Autor:
Daniel Leino, Alexander Miethke, Chunyue Yin, Jillian L. Ellis, John D. Schuetz, C. Alexander Valencia, Kevin E. Bove, Erin G. Schuetz
Publikováno v:
Hepatology. 67:1531-1545
Bile salt export pump (BSEP) adenosine triphosphate-binding cassette B11 (ABCB11) is a liver-specific ABC transporter that mediates canalicular bile salt excretion from hepatocytes. Human mutations in ABCB11 cause progressive familial intrahepatic ch
Autor:
Jessica G. Borger, Benjamin G Dewals, Daniel M. Davis, Sheila Brown, Alexander T. Phythian-Adams, Annette M. Dougall, Adam N.R. Cartwright, Cecilia Johansson, Ruud H. P. Wilbers, Rachel J. Lundie, Peter C. Cook, Lucy H. Jackson-Jones, Franca Ronchese, Andrew S. MacDonald, Lauren M. Webb, Lisa M. Connor
Publikováno v:
The EMBO Journal 36 (2017) 16
Webb, L M, Lundie, R J, Borger, J G, Brown, S, Connor, L M, Cartwright, A N R, Dougall, A M, Wilbers, R, Cook, P, Jackson-Jones, L, Phythian-Adams, A T, Johansson, C, Davis, D M, Dewals, B G, Ronchese, F & MacDonald, A 2017, ' Type I interferon is required for T helper (Th) 2 induction by dendritic cells ', EMBO Journal . https://doi.org/10.15252/embj.201695345
The EMBO Journal, 36(16), 2404-2418
The EMBO Journal
Webb, L, Lundie, R J, Borger, J G, Brown, S, Connor, L M, Cartwright, A, Dougall, A M, Wilbers, R H P, Cook, P, Jackson-Jones, L H, Phythian-Adams, A, Johansson, C, Davis, D M, Dewals, B G, Ronchese, F & MacDonald, A 2017, ' Type I interferon is required for T helper (Th) 2 induction by dendritic cells ', The EMBO Journal, vol. 36, no. 16, pp. 2404-2418 . https://doi.org/10.15252/embj.201695345
Webb, L M, Lundie, R J, Borger, J G, Brown, S, Connor, L M, Cartwright, A N R, Dougall, A M, Wilbers, R, Cook, P, Jackson-Jones, L, Phythian-Adams, A T, Johansson, C, Davis, D M, Dewals, B G, Ronchese, F & MacDonald, A 2017, ' Type I interferon is required for T helper (Th) 2 induction by dendritic cells ', EMBO Journal . https://doi.org/10.15252/embj.201695345
The EMBO Journal, 36(16), 2404-2418
The EMBO Journal
Webb, L, Lundie, R J, Borger, J G, Brown, S, Connor, L M, Cartwright, A, Dougall, A M, Wilbers, R H P, Cook, P, Jackson-Jones, L H, Phythian-Adams, A, Johansson, C, Davis, D M, Dewals, B G, Ronchese, F & MacDonald, A 2017, ' Type I interferon is required for T helper (Th) 2 induction by dendritic cells ', The EMBO Journal, vol. 36, no. 16, pp. 2404-2418 . https://doi.org/10.15252/embj.201695345
Type 2 inflammation is a defining feature of infection with parasitic worms(helminths), as well as being responsible for widespread suffering in allergies.However, the precise mechanisms involved in T helper (Th) 2 polarization bydendritic cells (DCs
Autor:
William O.C.M. Cookson, Maria-Belen Trujillo-Torralbo, Nicholas Glanville, Patrick Mallia, Phillip James, Elena M. Turek, Aran Singanayagam, Nathan W. Bartlett, Peter Fenwick, Eteri Bakhsoliani, Leah Cuthbertson, Maria Adelaide Calderazzo, Samuel V. Kemp, Lydia J. Finney, Thomas B. Clarke, Michael R. Edwards, Jadwiga A. Wedzicha, Joseph Footitt, Sebastian L. Johnston, Miriam F. Moffatt
Publikováno v:
Sci Transl Med
Bacterial infection commonly complicates inflammatory airway diseases such as chronic obstructive pulmonary disease (COPD). The mechanisms of increased infection susceptibility and how use of the commonly prescribed therapy inhaled corticosteroids (I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbb93cf723a7c0f847ce75e498258b4b
https://europepmc.org/articles/PMC7237237/
https://europepmc.org/articles/PMC7237237/
Autor:
Mireia Sospedra, Mohsen Khademi, Yanneth Ortiz, Katrin Frauenknecht, Lennart Opitz, Sabrina Ruhrmann, Radleigh G. Santos, Tomas Olsson, Verena Lentsch, Richard Reynolds, Andreas Lutterotti, Christian Hammer, Aleksandar Madjovski, Ilijas Jelcic, Wolfgang Faigle, Onur Boyman, Faiez Al Nimer, Gerhard Rogler, Raquel Planas, Clemencia Pinilla, Roland Martin, Hans Grönlund, Frederik Piehl, Ivan Jelcic, Jian Wang
Publikováno v:
Cell
Cell, 175 (1)
Cell, 175 (1)
Summary Multiple sclerosis is an autoimmune disease that is caused by the interplay of genetic, particularly the HLA-DR15 haplotype, and environmental risk factors. How these etiologic factors contribute to generating an autoreactive CD4+ T cell repe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b0e5732426c4e2a7126606e8c13f83a
https://www.zora.uzh.ch/id/eprint/158837/
https://www.zora.uzh.ch/id/eprint/158837/
Autor:
Maoyi Lai, María Salvador-Bernáldez, Changchun Xiao, Jesus M. Salvador, Alicia Gonzalez-Martin, David Nemazee, Jun Lu, Jovan Shepherd, Brian D. Adams
Publikováno v:
Nature immunology
Autoreactive B cells have critical roles in a large diversity of autoimmune diseases, but the molecular pathways that control these cells remain poorly understood. We performed an in vivo functional screen of a lymphocyte-expressed microRNA library a