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Autor:
H Fiegl, Lourdes Rocamora-Reverte, Walther Parson, Claudia Soratroi, Gerlinde Karbon, Haschka, Hubert Hackl, Andreas Villunger
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Breast cancer (BC) treatment frequently involves microtubule-targeting agents (MTAs), such as paclitaxel, that arrest cells in mitosis. Sensitivity to MTAs is defined by a subset of pro- and anti-apoptotic BCL2 family proteins controlling mitochondri
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-10 (2021)
Cell Death & Disease
Cell Death & Disease
Amino acid availability is sensed by various signaling molecules, including general control nonderepressible 2 (GCN2) and mechanistic target of rapamycin complex 1 (mTORC1). However, it is unclear how these sensors are associated with cancer cell sur
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Aberrant microRNA (miR) expression plays an important role in pathogenesis of different types of cancers, including B-cell lymphoid malignancies and in the development of chemo-sensitivity or -resistance in chronic lymphocytic leukemia (CLL) as well
Autor:
Zhili Ren, Ligong Lu, Xiaohong Li, Wei Ge, Chon Lok Lei, Weiwei Liu, Xiangyu Yang, Meixiao Zhan, Chengcheng Song, Dongjin Wang, Nana Ai, Jiaxian Wang, Yang Yang, Guokai Chen, Ya Meng
Publikováno v:
Cell Death and Disease, Vol 12, Iss 12, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
Nicotinamide, the amide form of Vitamin B3, is a common nutrient supplement that plays important role in human fetal development. Nicotinamide has been widely used in clinical treatments, including the treatment of diseases during pregnancy. However,
Autor:
Jie Chen, Xinhong Zhu, Yang Liu, Hui Huang, Kun Zhang, Changming Xie, Jieping Huang, Wanbing He
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-10 (2021)
Cell Death & Disease
Cell Death & Disease
Vascular calcification is common in chronic kidney disease (CKD) and contributes to cardiovascular disease (CVD) without any effective therapies available up to date. The expression of soluble epoxide hydrolase (sEH) is different in patients with and
Autor:
Lindsey M. Ludwig, David B. Banks, Anika T. Thomas-Toth, Katrina M. Hawley, Megan E. McNerney, Joel D. Leverson, James L. LaBelle, Bruce R. Blazar
Publikováno v:
Cell Death and Disease, Vol 12, Iss 11, Pp 1-13 (2021)
Cell Death & Disease
Cell Death & Disease
BH3 mimetics are increasingly used as anti-cancer therapeutics either alone or in conjunction with other chemotherapies. However, mounting evidence has also demonstrated that BH3 mimetics modulate varied amounts of apoptotic signaling in healthy immu
Autor:
Alessia Niceforo, Philip L Yates, Alvin V. Terry, Kimberly Sullivan, Emanuela Piermarini, Ramnik S. Gill, Peter W. Baas, Ankita Patil, Liang Qiang, Wayne D. Beck, Patrick M. Callahan, Xiaohuan Sun
Publikováno v:
Cell Mol Life Sci
Gulf War Illness (GWI), a disorder suffered by approximately 200,000 veterans of the first Gulf War, was caused by exposure to low-level organophosphate pesticides and nerve agents in combination with battlefield stress. To elucidate the mechanistic
Autor:
Congcong Zhang, Zhixian Wang, Xin Xu, Lifang Ma, Jiayi Wang, Yongjie Niu, Yongchun Yu, Yan Li
Publikováno v:
Cell Death and Disease, Vol 12, Iss 10, Pp 1-11 (2021)
Cell Death & Disease
Cell Death & Disease
Diabetes is an important risk factor for liver cancer, but its mechanism is unknown. Corosolic acid (CA) has been proven to have both hypoglycemic and antitumor effects, so revealing the function of CA can help us understand the relationship between
Publikováno v:
Curr Opin Lipidol
Current opinion in lipidology, vol 32, iss 5
Current opinion in lipidology, vol 32, iss 5
PURPOSE OF REVIEW: This paper reviews the mechanisms of high density lipoprotein cholesterol immunomodulation in the context of the mechanisms of chronic inflammation and immunosuppression causing persistent inflammation, immunosuppression, and catab
Autor:
Zheng Dong, Jane Ding, Yunhong Zha, Han Fei Ding, Chunhong Yan, Yajie Yu, Ahmet Alptekin, Shunqin Zhu
Publikováno v:
Cell Death and Disease, Vol 12, Iss 9, Pp 1-12 (2021)
Cell Death & Disease
Cell Death & Disease
Metabolic reprogramming is an integral part of the growth-promoting program driven by the MYC family of oncogenes. However, this reprogramming also imposes metabolic dependencies that could be exploited therapeutically. Here we report that the pyrimi