Zobrazeno 1 - 10
of 264
pro vyhledávání: '"11"'
Publikováno v:
Cancer Res
Malignant peripheral nerve sheath tumors often arise in patients with neurofibromatosis type 1 and are among the most treatment-refractory types of sarcoma. Overall survival in patients with relapsed disease remains poor, and thus novel therapeutic a
Publikováno v:
Cancer Res
Oncogenic protein tyrosine phosphatases have long been viewed as drug targets of interest, and recently developed allosteric inhibitors of SH2 domain–containing phosphatase-2 (SHP2) have entered clinical trials. However, the ability of phosphatases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23ab0aed440d4e6fa5a2e2f04abd181d
https://europepmc.org/articles/PMC8394281/
https://europepmc.org/articles/PMC8394281/
Autor:
Wei Liu, Wen-Mei Yu, Mignon L. Loh, Jing Zhang, Cheng-Kui Qu, Rebecca J. Chan, Kevin D. Bunting, Zheng Zhang
Publikováno v:
Leukemia
Leukemia, vol 31, iss 6
Leukemia, vol 31, iss 6
Activating mutations, such as E76K and D61Y, in PTPN11 (SHP2), a protein tyrosine phosphatase implicated in multiple cell signaling processes, are associated with 35% of patients with juvenile myelomonocytic leukemia (JMML), an aggressive childhood m
Autor:
Cheng Zheng, Haixing Ju, Zewei Zhang, Haitao Chen, Lulu Huang, Qinghua Yao, Xiafang Zhang, Yan Wang, Chao Xu
Publikováno v:
Oncology Research
The tripartite motif-containing protein 11 (TRIM11), a member of the TRIM protein family, has attracted much attention because of its involvement in the development of the central nervous system. It has gained renewed focus because of its newly found
Autor:
James R. Cerhan, Stephen M. Ansell, Neil E. Kay, Ahmet Dogan, Timothy G. Call, Zachary S. Fredericksen, Alice H. Wang, Mark Liebow, Susan L. Slager, Thomas M. Habermann, Thomas E. Witzig, Jennifer L. Kelly, Anne J. Novak
Publikováno v:
Cancer Epidemiology, Biomarkers & Prevention. 19:2847-2858
Background: The t(14;18)(q32;q21) translocation is the most commonly observed chromosomal translocation in non–Hodgkin's lymphoma (NHL), resulting in constitutive Bcl-2 expression and apoptosis inhibition. In addition, germline variation in both BC
Autor:
Jun Qi, Stephen E. Sallan, Kristen E. Stevenson, Justine E. Roderick, Loren D. Walensky, James E. Bradner, Michelle A. Kelliher, Lewis B. Silverman, Donna Neuberg, R Mathieu, Alejandro Gutierrez, U Pyati, Kimberly Bodaar, Marian H. Harris, Christine J. Reynolds, James L. LaBelle, A T Look, Gregory H. Bird, D Colon
Publikováno v:
Leukemia
Treatment resistance in T-cell acute lymphoblastic leukemia (T-ALL) is associated with phosphatase and tensin homolog (PTEN) deletions and resultant phosphatidylinositol 3'-kinase (PI3K)-AKT pathway activation, as well as MYC overexpression, and thes
Autor:
Wen Mei Yu, Olgun Guvench, Mignon L. Loh, Li Da Tang, Wei Liu, Cheng-Kui Qu, Alexander D. MacKerell, Bing Yu, Shawn P. Alter
Publikováno v:
Molecular Cancer Therapeutics. 12:1738-1748
Activating mutations in PTPN11 (encoding SHP2), a protein tyrosine phosphatase (PTP) that plays an overall positive role in growth factor and cytokine signaling, are directly associated with the pathogenesis of Noonan syndrome and childhood leukemias
Autor:
Caterina Marchiò, Milena Rondón-Lagos, Giorgio V. Scagliotti, Sandra Ramírez-Clavijo, Nelson Rangel, Teresa Mele, Ludovica Verdun di Cantogno, Anna Sapino
Publikováno v:
Repositorio EdocUR-U. Rosario
Universidad del Rosario
instacron:Universidad del Rosario
BMC Cancer
Universidad del Rosario
instacron:Universidad del Rosario
BMC Cancer
Background: In diagnostic pathology, HER2 status is determined in interphase nuclei by fluorescence in situ hybridization (FISH) with probes for the HER2 gene and for the chromosome 17 centromere (CEP17). The latter probe is used as a surrogate for c
Publikováno v:
Clinical Cancer Research. 17:1784-1795
Purpose: Our previous studies have shown that benzyl isothiocyanate (BITC) suppress pancreatic cancer growth by inducing apoptosis but the molecular mechanism was unclear. In this study we hypothesized the involvement of PI3K/AKT/FOXO pathway in BITC
Autor:
Mien Chie Hung, Jared K. Burks, Michael Andreeff, Karen C. Dywer, Teresa McQueen, Marina Konopleva, Jer Yen Yang, Weiguo Zhang, Wendy D. Schober
Publikováno v:
Cancer Research. 70:2424-2434
Molecular aberrations of the Ras/Raf/mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) kinase (MEK)/ERK and/or Murine double minute (MDM2)/p53 signaling pathways have been reported in 80% and 50% of primary acute myeloid le