Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Peter K, Gregersen"'
Autor:
Chander Raman, Jason Ptacek, Christopher C. Striebich, James R. O'Dell, Alessandra Cesano, Garry P. Nolan, Nancy A. Shadick, E. William St. Clair, Franak Batliwalla, S. Louis Bridges, Guy Cavet, Marc C. Levesque, William H. Robinson, Mark C. Genovese, Geoffrey M. Thiele, Erik Evensen, Barbara B. Mittleman, Cynthia Aranow, Maria I. Danila, Betty Diamond, Houman Khalili, Stacey S. Cofield, Dongmei Sun, Clifton O. Bingham, Larry W. Moreland, Matthew Hale, Peter K. Gregersen, Jeffrey R. Curtis, Rachael E. Hawtin, Peter A. Nigrovic, Richard A. Furie, Meggan Mackay, Brent Louie
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 1, p e0244187 (2021)
PLoS ONE, Vol 16, Iss 1, p e0244187 (2021)
Rheumatoid arthritis (RA) is a systemic and incurable autoimmune disease characterized by chronic inflammation in synovial lining of joints. To identify the signaling pathways involved in RA, its disease activity, and treatment response, we adapted a
Autor:
Jing Cui, Peter K. Gregersen, Nancy A. Shadick, Charles Curtis, Hamel Patel, Andrew P. Cope, Ann W. Morgan, Matthew Traylor, Annette H M van der Helm-van Mil, Ian C. Scott, Rachel Knevel, Stephen Newhouse, Paul Emery, Philip G. Conaghan, Michael E. Weinblatt, Westra Harm-Jan, John W. Taylor, Cathryn M. Lewis, Sophia Steer, Jennifer H. Barrett
Publikováno v:
PLoS ONE
PLoS ONE, Vol 14, Iss 10, p e0223246 (2019)
PLoS ONE, 14(10). PUBLIC LIBRARY SCIENCE
PLoS ONE, Vol 14, Iss 10, p e0223246 (2019)
PLoS ONE, 14(10). PUBLIC LIBRARY SCIENCE
Background\ud Previous studies of radiological damage in rheumatoid arthritis (RA) have used candidate-gene approaches, or evaluated single genome-wide association studies (GWAS). We undertook the first meta-analysis of GWAS of RA radiological damage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::698d0a649f6bf086f4d87ff91fe373b7
https://eprints.whiterose.ac.uk/151082/26/journal.pone.0223246.pdf
https://eprints.whiterose.ac.uk/151082/26/journal.pone.0223246.pdf
Autor:
Taylor K. Farley, In Ah Choi, Geoffrey M. Thiele, Kevin D. Deane, Jill M. Norris, Eric T. Hawley, Sabina R. Mian, Eun Young Lee, Michael M. Ward, Naveen Gara, Peter K. Gregersen, V. Michael Holers, James R. O'Dell, Yun-Jeong Song, John Botson, Arianne C. Richard, Françoise Meylan, William Stohl, Ted R. Mikuls, Bartlett C. Hamilton, Christopher D. Ward, Theo Heller, David M. Lee, Thi-Sau Migone, S. Lamberth, Richard M. Siegel, Yoo Jin Hong, Yeong Wook Song, M. Kristen Demoruelle
Publikováno v:
Arthritis Research & Therapy
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-14 (2020)
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-14 (2020)
Background The tumor necrosis factor (TNF) superfamily cytokine TNF-like protein 1A (TL1A) and its receptor DR3 are essential for diverse animal models of autoimmune disease and may be pathogenic in rheumatoid arthritis (RA). However, the relationshi
Autor:
C. Michael Stein, Annette Oeser, Peter K. Gregersen, Iván Ferraz-Amaro, Richard J. Reynolds, Robert Winchester, Joan M. Bathon, Jon T. Giles, Cecilia P. Chung, Mary Chester M. Wasko
Publikováno v:
Arthritis & Rheumatology. 69:529-541
Objective. Coronary artery disease (CAD) in the general population is characterized by an increased frequency of particular susceptibility single nucleotide polymorphisms (SNPs). Since CAD is increased in rheumatoid arthritis (RA), we sought to deter
Autor:
Shun-Chiao Chang, Kevin D. Deane, James R. O'Dell, Michael H. Weisman, Karen H. Costenbader, M. Kristen Demoruelle, V. Michael Holers, Richard M. Keating, Jill M. Norris, Elizabeth W. Karlson, Ted R. Mikuls, Jane H. Buckner, Marie L. Feser, Laura Kay Moss, Peter K. Gregersen, Ryan W. Gan, Jeffrey A. Sparks
Publikováno v:
Arthritis & Rheumatology. 68:1828-1838
Objective To examine whether genetic, environmental, and serologic rheumatoid arthritis (RA) risk factors are associated with inflammatory joint signs in a cohort of first-degree relatives (FDRs) of RA patients. Methods We evaluated RA risk factors a
Autor:
Elvia G. Moreta, James T. Elder, Michael Weichenthal, Sayantan Das, Trilokraj Tejasvi, Proton Rahman, Anne M. Bowcock, Philip E. Stuart, Markus M. Nöthen, Tõnu Esko, Ulrich Mrowietz, Philip J. Mease, Christopher T. Ritchlin, Robert W. Ike, Per Hoffmann, Rajan P. Nair, Christian Gieger, Charlotta Enerbäck, Stephan Weidinger, Manfred Kunz, Gerald G. Krueger, Peter K. Gregersen, André Reis, John J. Voorhees, Külli Kingo, Vinod Chandran, Sulev Kõks, Eva Ellinghaus, Xiaoquan Wen, Hyun Min Kang, H.-Erich Wichmann, Lam C. Tsoi, Andre Franke, Johann E. Gudjonsson, Kristina Callis-Duffin, Gonçalo R. Abecasis, Henry W. Lim, Juliane Winkelmann, Dafna D. Gladman, Yanming Li
Publikováno v:
The American Journal of Human Genetics
Am. J. Hum. Genet. 97, 816-836 (2015)
Am. J. Hum. Genet. 97, 816-836 (2015)
Psoriasis vulgaris (PsV) is a common inflammatory and hyperproliferative skin disease. Up to 30% of people with PsV eventually develop psoriatic arthritis (PsA), an inflammatory musculoskeletal condition. To discern differences in genetic risk factor
Autor:
Joshua Hillman, Mandy J. McGeachy, Nir Hacohen, Brendan F. Boyce, David L. Boyle, V. Michael Holers, Paul J. Utz, Maria Gutierrez-Arcelus, Peter K. Gregersen, Joshua Keegan, Susan M. Goodman, Thomas Eisenhaure, Cristina Rozo, Stephen Kelly, Nida Meednu, Accelerating Medicines Partnership Ra, William H. Robinson, Deepak A. Rao, Edward P. Browne, Shuqiang Li, Kaylin Muskat, Andrew Filer, Vivian P. Bykerk, Danielle Sutherby, Laura T. Donlin, Gary S. Firestein, Chad Nusbaum, Kevin Wei, Fumitaka Mizoguchi, Kamil Slowikowski, Akiko Noma, Edd Ricker, Larry W. Moreland, Lionel B. Ivashkiv, Michael B. Brenner, Alessandra B. Pernis, Jennifer H. Anolik, David J. Lieb, Jason D. Turner, Soumya Raychaudhuri, James A. Lederer, Ellen M. Gravallese, Costantino Pitzalis, Adam Chicoine
Publikováno v:
Arthritis Research & Therapy, Vol 20, Iss 1, Pp 1-15 (2018)
Arthritis Research & Therapy
Arthritis research & therapy, vol 20, iss 1
Arthritis Research & Therapy
Arthritis research & therapy, vol 20, iss 1
Background Detailed molecular analyses of cells from rheumatoid arthritis (RA) synovium hold promise in identifying cellular phenotypes that drive tissue pathology and joint damage. The Accelerating Medicines Partnership RA/SLE Network aims to decons
Autor:
Marlena Kern, David Chernoff, Cassandra Pond, Michael E. Weinblatt, Michael J. Townsend, Jennifer D. Hamilton, Michaela Oswald, John P. Carulli, Robert M. Townsend, S. Lamberth, Annette Lee, Mark Curran, Peter K. Gregersen
Publikováno v:
Arthritis & Rheumatology. 67:344-351
Objective To establish whether the analysis of whole blood gene expression can be useful in predicting or monitoring response to anti-TNF therapy in RA.
Autor:
S. Louis Bridges, Laura B. Hughes, Maria I. Danila, Robert M. Plenge, Altan F. Ahmed, Peter K. Gregersen, Soumya Raychaudhuri, Richard J. Reynolds
Publikováno v:
Arthritis & Rheumatology. 66:3274-3282
Objective To evaluate HLA-DRB1 genetic risk of rheumatoid arthritis (RA) in African Americans by 3 validated allele classification systems and by amino acid position and residue, and to compare genetic risk between African American and European ances
Autor:
Javier Martin, John A. Todd, Wei-Min Chen, Marta Martinez Bonet, Stephen S. Rich, Yang Luo, Aaron R. Quinlan, Lars Klareskog, Solbritt Rantapää-Dahlqvist, Annette Lee, Harm-Jan Westra, Peter A. Nigrovic, Soumya Raychaudhuri, Suna Onengut-Gumuscu, Jane Worthington, Nikola Teslovich, Steve Eyre, Tom W J Huizinga, Peter K. Gregersen
Publikováno v:
Nature Genetics
Nature Genetics, 50(10), 1366-1374. Nature Publishing Group
Nature Genetics, 50(10), 1366
Westra, H, Martínez-bonet, M, Onengut-gumuscu, S, Lee, A, Luo, Y, Teslovich, N, Worthington, J, Martin, J, Huizinga, T, Klareskog, L, Rantapaa-dahlqvist, S, Chen, W, Quinlan, A, Todd, J A, Eyre, S, Nigrovic, P A, Gregersen, P K, Rich, S S & Raychaudhuri, S 2018, ' Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes ', Nature Genetics, vol. 50, no. 10, pp. 1366-1374 . https://doi.org/10.1038/s41588-018-0216-7
Nature Genetics, 50(10), 1366-1374. Nature Publishing Group
Nature Genetics, 50(10), 1366
Westra, H, Martínez-bonet, M, Onengut-gumuscu, S, Lee, A, Luo, Y, Teslovich, N, Worthington, J, Martin, J, Huizinga, T, Klareskog, L, Rantapaa-dahlqvist, S, Chen, W, Quinlan, A, Todd, J A, Eyre, S, Nigrovic, P A, Gregersen, P K, Rich, S S & Raychaudhuri, S 2018, ' Fine-mapping and functional studies highlight potential causal variants for rheumatoid arthritis and type 1 diabetes ', Nature Genetics, vol. 50, no. 10, pp. 1366-1374 . https://doi.org/10.1038/s41588-018-0216-7
To define potentially causal variants for autoimmune disease, we fine-mapped1,2 76 rheumatoid arthritis (11,475 cases, 15,870 controls)3 and type 1 diabetes loci (9,334 cases, 11,111 controls)4. After sequencing 799 1-kilobase regulatory (H3K4me3) re