Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Trant, A. (A.)"'
Autor:
J M Trant, Yukinori Kazeto
Publikováno v:
Journal of Molecular Endocrinology. 35:571-583
Cytochrome P450 aromatase (CYP19) converts androgens to estrogens. Unlike mammals, teleosts have two CYP19 genes, expressed differentially in ovary (CYP19A1) and neuronal tissues (CYP19A2). The primary purpose of this study was to demonstrate the pot
Publikováno v:
Fish Physiology and Biochemistry. 28:29-32
Cytochrome P450-aromatase (CYP19) is the critical steroidogenic enzyme controlling estrogen biosynthesis. In teleosts, two genes for CYP19 are found with CYP19A1 expressed mainly in the ovary and CYP19A2 expressed in both brain and pituitary. The pro
Publikováno v:
Molecular and Cellular Endocrinology. 172:115-124
Functional differences exist between the porcine gonadal and placental aromatase cytochrome P450 (P450arom) isozymes that are encoded by separate genes. The present experiments investigated the sub-cellular location of these isozymes, their dependenc
Publikováno v:
Endocrinology. 140:5202-5210
Differences in the catalytic activity of the placental and gonadal isozymes of porcine aromatase cytochrome P450 (P450arom) were examined in cell lines exhibiting stable expression of recombinant enzyme. Cell lines were selected that expressed high,
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 61:393-397
The cDNA encoding the catfish ovarian aromatase has previously been isolated and described (accession number S75715). As demonstrated previously, the predicted amino acid sequence and enzymatic activity of the encoded protein share a significant degr
Autor:
J I Mason, William Byrd, Michael R. Waterman, John M. Trant, Jan M. McAllister, Evan R. Simpson
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 71:26-33
The development of long term culture conditions with which to study the regulation of expression of aromatase, cholesterol side-chain cleavage enzyme, and 3 beta-hydroxysteroid dehydrogenase (3 beta HSD) in human granulosa-lutein cells is described i
Publikováno v:
Environmental toxicology and chemistry. 25(9)
The aim of the present work was to study the effects of the peroxisome proliferator dibutylphthalate (DBP) and the xenoestrogen 17alpha-ethynylestradiol (EE2) on liver peroxisomes, reproduction, and development of zebrafish (Danio rerio). In experime
Publikováno v:
General and comparative endocrinology. 139(1)
Estradiol plays a key role in the control of many behavioral and physiological aspects of reproduction therefore the expression of cytochrome P450 aromatase (CYP19), the enzyme responsible for the conversion of androgens to estrogens, is of vital int
Publikováno v:
Aquatic toxicology (Amsterdam, Netherlands). 69(1)
Cytochrome P450 aromatase (CYP19) is the key steroidogenic enzyme responsible for conversion of androgens to estrogens which play a critical role in developmental sex differentiation and adult reproductive cycles in vertebrates. To evaluate the poten
Autor:
John M. Trant, Alan J Conley, Samantha Mapes, Doug Greger, K. W. Walters, C. J. Corbin, Sandra E. Graham
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 79(1-5)
To date, structure–function studies of aromatase cytochrome P450 (P450arom) have been advanced by point mutation analyses utilizing almost exclusively the human enzyme, in conjunction with computer-generated models of the three-dimensional form of