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Autor:
Rocco C. Venuto, Kathleen M. Tornatore, Joseph D. Consiglio, Calvin J. Meaney, Louise M. Cooper, Daniel A. Brazeau, Gregory E. Wilding
Publikováno v:
J Clin Pharmacol
Mycophenolic acid exhibits significant interpatient pharmacokinetic variability attributed to factors including race, sex, concurrent medications, and enterohepatic circulation of the mycophenolic acid glucuronide metabolite to mycophenolic acid. Thi
Autor:
Fumio Nagashima, Shun Kaneko, Daisuke Naruge, Takashi Furuta, Yuki Minowa, Kirio Kawai, Naohiro Okano, Ryohei Hirano, Takaaki Kobayashi, Hiromi Shibasaki, Sayuri Endo, Akitomo Yokokawa, Hideaki Ayukawa, Junji Furuse
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics. 46:317-324
Irinotecan (CPT-11) is metabolized to an active metabolite 7-ethyl-10-hydroxycamptothecin (SN-38) by carboxylesterase (CES). SN-38 is then converted to the inactive metabolite SN-38 glucuronide (SN-38G) by glucuronosyltransferase 1A1 (UGT1A1). Geneti
Autor:
Agnieszka Karbownik, Joanna Stanisławiak-Rudowicz, Michał Romański, Anna Stachowiak, Edyta Szałek, Edmund Grześkowiak
Publikováno v:
European Journal of Drug Metabolism and Pharmacokinetics
Background and Objective Sorafenib is an oral, multikinase inhibitor with established single-agent activity in several tumor types. Sorafenib was moderately transported by P-glycoprotein (P-gp) and more efficiently by breast cancer resistance protein
Publikováno v:
Int. Journal of Clinical Pharmacology and Therapeutics. 58:408-414
Objective The objective of this study was to use LC-MS/MS to compare the pharmacodynamic properties and bioequivalence of two 200-mg formulations of racecadotril: suspension formulation (test) and granule formulation (reference) in healthy Chinese su
Publikováno v:
The Journal of Clinical Pharmacology. 60:1314-1323
The effects of itraconazole on the pharmacokinetics of rovatirelin were investigated in an open-label, single-sequence drug-drug interaction study in 16 healthy subjects. Subjects were administered a single oral dose of rovatirelin (1.6 mg) on day 1
Publikováno v:
Int. Journal of Clinical Pharmacology and Therapeutics. 58:230-241
Objective Sofosbuvir is an NS5B nucleotide inhibitor that was approved for hepatitis C treatment. Generic sofosbuvir has been produced to improve the affordability. The present study investigated the pharmacokinetics (PK) and safety of generic sofosb
Autor:
Chen Siying, Lu Yuan, Xiaoqing Zhu, Yongjun Li, Yueting Li, Chuang Cao, Jie Pan, Liu Chunhua, Sun Jia, Liu Ting, Jing Huang, Shuai Zhang, Wang Yonglin
Publikováno v:
BMC Pharmacology & Toxicology
BMC Pharmacology and Toxicology, Vol 22, Iss 1, Pp 1-8 (2021)
BMC Pharmacology and Toxicology, Vol 22, Iss 1, Pp 1-8 (2021)
Background Aidi Injection (ADI), a Chinese herbal preparation with anti-cancer activity, is used for the treatment of hepatocellular carcinoma (HCC). Several clinical studies have shown that co-administration of ADI with doxorubicin (DOX) is associat
Publikováno v:
Journal of clinical pharmacologyReferences. 61(11)
Fluoxetine is a selective serotonin reuptake inhibitor that is metabolized to norfluoxetine by cytochrome P450 (CYP) 2D6, CYP2C19, and CYP3A4. A physiologically based pharmacokinetic model for fluoxetine and norfluoxetine metabolism was developed to
Publikováno v:
British Journal of Clinical Pharmacology, 85(5), 1003-1014. Wiley
Br J Clin Pharmacol
Br J Clin Pharmacol
Aims Agomelatine is an antidepressant for major depressive disorders. It undergoes extensive first-pass hepatic metabolism and displays irregular absorption profiles and large interindividual variability (IIV) and interoccasion variability of pharmac
Autor:
Zhenwei Shen, Guiling Chen, Junqi Niu, Xiaojiao Li, Xiaoxue Zhu, Yanhua Ding, Hong Zhang, Hong Chen
Publikováno v:
Clinical Pharmacology in Drug Development. 8:1073-1080
Sofosbuvir is an NS5B nucleotide inhibitor for the treatment of hepatitis C viral infection. In this study the pharmacokinetics (PK) and safety of single and multiple doses of generic sofosbuvir were investigated in healthy Chinese subjects. Twelve s