Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Yajun Yan"'
Autor:
Liangyu Lu, Xiaolei Wang, Lei Zhou, Qiyuan Liu, Guanghao Zhang, Bingqing Xue, Chenyu Hu, Xiaolin Shen, Xinxiao Sun, Yajun Yan, Jia Wang, Qipeng Yuan
Publikováno v:
Metabolic Engineering. 76:110-119
Autor:
Xianglai Li, Nan Li, Mengyuan Zhao, Zhao Zhou, Wenna Li, Xiaolin Shen, Jia Wang, Yajun Yan, Xinxiao Sun, Qipeng Yuan
Publikováno v:
Biotechnology and Bioengineering. 120:503-510
Orotate (OA) is a precursor of pyrimidine nucleotides and is widely used in food, pharmaceutical, and cosmetic industries. Although various microorganisms have been used for OA production, the production efficiency needs to be further improved for in
Autor:
Zhao Zhou, Xiangyan Zhang, Jun Wu, Xianglai Li, Wenna Li, Xinxiao Sun, Jia Wang, Yajun Yan, Xiaolin Shen, Qipeng Yuan
Publikováno v:
Metabolic Engineering. 73:247-255
Ferulic acid (FA) is a natural methylated phenolic acid which represents various bioactivities. Bioproduction of FA suffers from insufficient methyl donor supplement and inefficient hydroxylation. To overcome these hurdles, we first activate the S-ad
Publikováno v:
Biotechnology and Bioengineering. 119:2518-2528
Allantoin is an important fine chemical that can be widely used in pharmaceutical, cosmetic and agricultural industries. Currently, allantoin is mainly produced by plant extraction or chemical synthesis. Due to the cost and environmental concerns, bi
Publikováno v:
Metab Eng
Dynamic regulation has been proved efficient in controlling gene expression at transcriptional, translational, and post-translational level. However, the dynamic regulation at gene replication level has been rarely explored so far. In this study, we
Publikováno v:
Metabolic engineering. 74
Endogenous metabolic pathways in microbial cells are usually precisely controlled by sophisticated regulation networks. However, the lack of such regulations when introducing heterologous pathways in microbial hosts often causes unbalanced enzyme exp
Autor:
Jian Wang, Yuxi Teng, Xinyu Gong, Jianli Zhang, Yifei Wu, Lei Lou, Michelle Li, Zhong-Ru Xie, Yajun Yan
Publikováno v:
Metabolic engineering. 75
The RNA-guided Cas9s serve as powerful tools for programmable gene editing and regulation; their targeting scopes and efficacies, however, are always constrained by the PAM sequence stringency. Most Streptococci Cas9s, including the prototype SpCas9
Publikováno v:
Metabolic engineering. 75
With rapid advances in the development of metabolic pathways and synthetic biology toolkits, a persisting challenge in microbial bioproduction is how to optimally rewire metabolic fluxes and accelerate the concomitant high-throughput phenotype screen
Autor:
Xiaolin Shen, Yajun Yan, Xinxiao Sun, Ning An, Yijie Jing, Jia Wang, Huakang Sheng, Qipeng Yuan
Publikováno v:
Biotechnology and Bioengineering. 118:1840-1850
Maleate is one of the most important unsaturated four-carbon dicarboxylic acids. It serves as an attractive building block in cosmetic, polymer, and pharmaceutical industries. Currently, industrial production of maleate relies mainly on chemical synt
Publikováno v:
Microbial Cell Factories, Vol 19, Iss 1, Pp 1-11 (2020)
Microbial Cell Factories
Microbial Cell Factories
Aromatic polyketides have attractive biological activities and pharmacological properties. Different from other polyketides, aromatic polyketides are characterized by their polycyclic aromatic structure. The biosynthesis of aromatic polyketides is us