Zobrazeno 1 - 10
of 21
pro vyhledávání: '"David G. Hoel"'
Autor:
Tomas Radivoyevitch, David G. Hoel
Publikováno v:
Mathematical Biosciences. 162:85-101
Formation of the BCR–ABL chromosomal translocation t (9;22)( q 34; q 11) is essential to the genesis of chronic myeloid leukemia (CML). An interest in the dose-response of radiation induced CML therefore leads naturally to an interest in the dose-r
Publikováno v:
Mathematical Biosciences. 149:107-136
When ionizing radiation strikes a cell it induces DNA double strand breaks (DSBs). Subsequently, some of the DSBs misrejoin and thus cause alterations in the size distribution of the DNA fragments. We derive a system of non-linear integro-differentia
Publikováno v:
Toxicology and Applied Pharmacology. 55:154-161
A general scheme is proposed which relates the carcinogenic responses to the amount of DNA-carcinogen adduct formed instead of applied dose. Based on the present understanding of the mechanism of carcinogenesis, we believe this to be a more rational
Autor:
David G. Hoel, Gerald R. Chase
Publikováno v:
Biometrika. 62:329-334
SUMMARY The effect of small errors of dilution is shown to be sizeable when serial dilutions are required to estimate particle concentrations. Optimal dilution designs are given. The error effect and optimal design are also investigated for ratios of
Publikováno v:
Biometrika. 62:195-200
We examine results produced by a new likelihood stopping rule for terminating clinical trials, designed to choose the better of two competing dichotomous treatments, or to decide that they are equal. A method for adaptive assignment is also discussed
Autor:
David G. Hoel, Robert I. Jennrich
Publikováno v:
Journal of Statistical Computation and Simulation. 20:311-322
Life table analysis techniques in epidemiology depend upon the asymptotic properties of the statistical test methods employed. In some instances, the statistical procedures indicate highly significant results which are, in reality, unjustified. The p
Autor:
Kenny S. Crump, David G. Hoel
Publikováno v:
Biometrika. 61:237-252
SUMMARY A number of mathematical models for cell populations in which mutations are occurring are studied and compared by viewing the models as filtered Poisson processes. Based upon these models, a statistical analysis is given of the mutant accumul
Publikováno v:
Journal of Statistical Computation and Simulation. 3:299-313
We consider the problem of choosing the best of k binomial populations when the time to response is non zero. Several sampling schemes are discussed, with an aim to making as few trials as possible with the poorer treatments, as would be a desideratu
Autor:
David G. Hoel
Publikováno v:
Technometrics. 10:331-341
A sample of unknown size n is obtained from a known population. The order statistics are then examined sequentially for the purpose of drawing inferences about n. A procedure for testing the unknown sample size n is given and its exact properties are
Autor:
David G. Hoel
Publikováno v:
Biometrika. 55:387-391
SUMMARY This paper is concerned with the application of several closed sequential procedures to the testing of an exponential parameter. In particular, the procedures of Armitage (1957), Schneiderman & Armitage (1962a,b) and Anderson (1960) are consi