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pro vyhledávání: '"Mengying Zhou"'
Autor:
Xiao Chen Bai, Mengying Zhou, Weiyun Huang, Chuangye Yan, Yini Li, Sjors H.W. Scheres, Yigong Shi, Qi Hu
Publikováno v:
Genes & Development. 29:2349-2361
The apoptotic protease-activating factor 1 (Apaf-1) controls the onset of many known forms of intrinsic apoptosis in mammals. Apaf-1 exists in normal cells as an autoinhibited monomer. Upon binding to cytochrome c and dATP, Apaf-1 oligomerizes into a
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 114(7)
Mammalian intrinsic apoptosis requires activation of the initiator caspase-9, which then cleaves and activates the effector caspases to execute cell killing. The heptameric Apaf-1 apoptosome is indispensable for caspase-9 activation by together formi