Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Sean C. Gehen"'
Publikováno v:
Oncogene. 27:4065-4074
Genotoxic stress activates the phosphatidylinositol 3-kinase like kinases (PIKKs) that phosphorylate proteins involved in cell cycle arrest, DNA repair, and apoptosis. Previous work showed that the PIKK ataxia telangiectasia mutated (ATM) but not ATR
Autor:
Peter F. Vitiello, Sean C. Gehen, Christopher E. Helt, Rhonda J. Staversky, Michael A. O'Reilly, Arshad Rahman, Peter C. Keng
Publikováno v:
Free radical biologymedicine. 41(4)
p21Cip1/WAF1/Sdi1 is a major transcriptional target of p53 that promotes survival of cells exposed to continuous oxidative stress caused by hyperoxia. Because p21 can protect against genotoxic stress by reducing p53-dependent transcription of the pro
Autor:
Jason M. Roper, Albert J. Fornace, Rhonda J. Staversky, Michael A. O'Reilly, Sean C. Gehen, M. Christine Hollander
Publikováno v:
American journal of physiology. Lung cellular and molecular physiology. 288(4)
It is well established that exposure to high levels of oxygen (hyperoxia) injures and kills microvascular endothelial and alveolar type I epithelial cells. In contrast, significant death of airway and type II epithelial cells is not observed at morta