Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Razq Hakem"'
Autor:
Neil MacLean, Shawn Brennan, Adam C. Smith, Rose Hurren, Allison Berger, Xiaoming Wang, Razq Hakem, Marcela Gronda, Mark D. Minden, Sara Farshchi Zarabi, Simon Kavanagh, Tary Traore, G. Wei Xu, Aaron D. Schimmer, Emil F. Pai, Samir H. Barghout, Ondrej Halgas, Michael Milhollen, Marc L. Hyer, Parasvi S. Patel, Danny V. Jeyaraju
Publikováno v:
Leukemia. 33:37-51
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy for which new therapeutic approaches are required. One such potential therapeutic strategy is to target the ubiquitin-like modifier-activating enzyme 1 (UBA1), the initiating enzyme
Autor:
Andreas Strasser, Emma C. Josefsson, Christopher P. Dillon, Lorraine A. O'Reilly, Diego A. Rodriguez, Marion Lebois, John Silke, Ann Lin, Warren S. Alexander, Najoua Lalaoui, Razq Hakem, Douglas R. Green, Maria C. Tanzer, Silvia Alvarez-Diaz
Publikováno v:
Immunity. 45:513-526
The kinases RIPK1 and RIPK3 and the pseudo-kinase MLKL have been identified as key regulators of the necroptotic cell death pathway, although a role for MLKL within the whole animal has not yet been established. Here, we have shown that MLKL deficien
Autor:
Paul R Lakin, Mary Speir, Heather Patsiouras, Ben A. Croker, Roman Othmar Braun, Shu Wang, Rowena S. Lewis, Razq Hakem, Akshay A. D’Cruz, Nathan E. Lewis, Andrew W. Roberts, Kate E. Lawlor, Anca I. Stoica, Louise H. Cengia, Isaac Shamie, Joanne A. O’Donnell, Edie Weller, Inbar Shlomovitz, Motti Gerlic, Meghan Bliss-Moreau, Jeffrey J. Babon, Lorraine A. O'Reilly, Alyce A. Chen, Cameron J. Nowell, Michelle A. Kelliher
Publikováno v:
Nature immunology
Ptpn6 is a cytoplasmic phosphatase that functions to prevent autoimmune and interleukin-1 (IL-1) receptor-dependent, caspase-1-independent inflammatory disease. Conditional deletion of Ptpn6 in neutrophils (Ptpn6∆PMN) is sufficient to initiate IL-1
Autor:
Mathilde Gavillet, Shu Wang, Ben A. Croker, David A. Williams, Michelle A. Kelliher, Meghan Bliss-Moreau, Sylvia Dietrich, Manolis Pasparakis, Alyce A. Chen, Akshay A. D’Cruz, Mary Speir, James E Vince, Arshed Al-Obeidi, Kate E. Lawlor, Maria Ericsson, Razq Hakem
Publikováno v:
Science signaling. 11(546)
Neutrophil extracellular trap (NET) formation can generate short-term, functional anucleate cytoplasts and trigger loss of cell viability. We demonstrated that the necroptotic cell death effector mixed lineage kinase domain–like (MLKL) translocated
Autor:
Jennifer L. Gommerman, Dania Haddad, Ahmad Zaheen, Olga L. Rojas, Bryant Boulianne, Alberto Martin, Razq Hakem, Thanh Nguyen, Anat Kapelnikov, Conglei Li
Publikováno v:
The Journal of Immunology. 191:5840-5847
Germinal centers (GCs) are clusters of activated B cells that form in secondary lymphoid organs during a T-dependent immune response. B cells enter GCs and become rapidly proliferating centroblasts that express the enzyme activation-induced deaminase
Autor:
Patrick Fitzgerald, Razq Hakem, Ricardo Weinlich, Laura L. McCormick, Douglas R. Green, Andrew Oberst, Cristina Pop, Christopher P. Dillon, Guy S. Salvesen
Publikováno v:
Nature
Caspase-8 mediates apoptosis induced by 'death receptors' on the cell's surface. At the same time, it is able to prevent receptor interacting protein kinase (RIPK)-dependent necrosis. Without caspase-8, mice die during embryonic development, but why
Autor:
Philipp J. Jost, Thomas Kaufmann, Andreas Strasser, Raffi Gugasyan, Tak W. Mak, Marc Pellegrini, Philippe Bouillet, Mark J. Smyth, Vishva M. Dixit, John Silke, Hamsa Puthalakath, Erika Cretney, Steve Gerondakis, Razq Hakem
Publikováno v:
Immunity
Apoptotic death of hepatocytes, a contributor to many chronic and acute liver diseases, can be a consequence of overactivation of the immune system and is often mediated by TNFalpha. Injection with lipopolysaccharide (LPS) plus the transcriptional in