Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Kelly M. Ramsbottom"'
Autor:
Tanja Fauti, Lisa Wellinger, Joseph A. Trapani, Axel Paehler, Daniela Geiss, Kelly M Ramsbottom, Laura Jarassier, Phillip Thienger, Leonie A. Cluse, Conor J. Kearney, Thomas Friess, Stephin J. Vervoort, Jane Oliaro, Daniel Rohle, Ricky W. Johnstone, Marina Bacac, Simon J. Hogg, Astrid Ruefli-Brasse, Dane M. Newman, Daniel Marbach, Jake Shortt, Jessica Michie
Publikováno v:
Cancer Immunology Research. 10:87-107
Targeting chromatin binding proteins and modifying enzymes can concomitantly affect tumor cell proliferation and survival, as well as enhance antitumor immunity and augment cancer immunotherapies. By screening a small-molecule library of epigenetics-
Autor:
Jane Oliaro, Conor J. Kearney, Jessica Michie, Kelly M Ramsbottom, John Silke, Andrew J. Freeman, Stephin J. Vervoort
Publikováno v:
EMBO Rep
The success of cancer immunotherapy is limited to a subset of patients, highlighting the need to identify the processes by which tumors evade immunity. Using CRISPR/Cas9 screening, we reveal that melanoma cells lacking HOIP, the catalytic subunit of
Autor:
Conor J. Kearney, John Silke, Kelly M Ramsbottom, Andrew J. Freeman, Jane Oliaro, Najoua Lalaoui
Publikováno v:
Cell Death & Differentiation. 24:1705-1716
Smac-mimetics are emerging as promising anti-cancer agents and are being evaluated in clinical trials for a variety of malignancies. Smac-mimetics can induce TNF production from a subset of tumor cells and simultaneously sensitize them to TNF-induced
Autor:
Kelly M Ramsbottom, Ilia Voskoboinik, Najoua Lalaoui, Conor J. Kearney, Paul A. Beavis, Jane Oliaro, Ricky W. Johnstone, Andrew J. Freeman, Robert G. Ramsay, Emily J. Lelliott, Jessica Michie, John Silke, Vignesh Narasimhan, Phillip K. Darcy, Stephin J. Vervoort
Publikováno v:
Cancer immunology research. 7(2)
Chimeric antigen receptor (CAR) T-cell therapy has proven successful in the treatment of hematological malignancies, notably acute lymphoblastic leukemia and B-cell lymphoma. However, the efficacy of CAR T cells against solid tumors is poor, likely d
Autor:
Sarah M. Russell, Andrea Newbold, Jane Oliaro, Ricky W. Johnstone, Kelly M Ramsbottom, Patrick O. Humbert, Edwin D. Hawkins
Publikováno v:
Oncogene. 35(9)
Scribble complex proteins maintain apicobasal polarity, regulate cell fate determination and function as tumour suppressors in epithelial tissue. Despite evidence that the function of Scribble is maintained in the lymphocyte lineage, we still underst