Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Karel Souček"'
Autor:
Tereza Kauerová, Tomáš Goněc, Josef Jampílek, Susanne Hafner, Ann-Kathrin Gaiser, Tatiana Syrovets, Radek Fedr, Karel Souček, Peter Kollar
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 10, p 3416 (2020)
Ring-substituted 1-hydroxynaphthalene-2-carboxanilides were previously investigated for their antimycobacterial properties. In our study, we have shown their antiproliferative and cell death-inducing effects in cancer cell lines. Cell proliferation a
Externí odkaz:
https://doaj.org/article/7fd99a0c57d94701934f9d8f3cde11b7
Autor:
Ximena M. Muresan, Eva Slabáková, Jiřina Procházková, Stanislav Drápela, Radek Fedr, Markéta Pícková, Ondřej Vacek, Ráchel Víchová, Tereza Suchánková, Jan Bouchal, Daniela Kürfürstová, Milan Král, Tereza Hulínová, Radek P. Sýkora, Vladimír Študent, Václav Hejret, Wytske M. van Weerden, Martin Puhr, Václav Pustka, David Potěšil, Zbyněk Zdráhal, Zoran Culig, Karel Souček
Publikováno v:
The American journal of pathology, 192(9), 1321-1335. Elsevier Inc.
Toll-like receptor 3 (TLR3) is an endosomal receptor expressed in several immune and epithelial cells. Recent studies have highlighted its expression also in solid tumors, including prostate cancer (PCa), and have described its role primarily in the
Autor:
Stanislav Drápela, Miroslav Boudny, Josef Jaroš, Michaela Špunarová, Jan Verner, Prashant Khirsariya, Zuzana Jašková, Kamil Paruch, Yvona Brychtová, Marie Kasparkova, Jana Zemanová, Jiri Mayer, Marek Borsky, Václav Šeda, Jana Černá, Martin Trbušek, Alexandra Oltová, Marek Mráz, Karel Souček
Publikováno v:
Haematologica
Introduction of small-molecule inhibitors of B-cell receptor signaling and BCL2 protein significantly improves therapeutic options in chronic lymphocytic leukemia. However, some patients suffer from adverse effects mandating treatment discontinuation
Autor:
Peter Kollar, Tatiana Syrovets, Tereza Kauerová, Radek Fedr, Tomáš Goněc, Ann-Kathrin Gaiser, Karel Souček, Josef Jampilek, Susanne Hafner
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 3416, p 3416 (2020)
International Journal of Molecular Sciences
Volume 21
Issue 10
International Journal of Molecular Sciences
Volume 21
Issue 10
Ring-substituted 1-hydroxynaphthalene-2-carboxanilides were previously investigated for their antimycobacterial properties. In our study, we have shown their antiproliferative and cell death-inducing effects in cancer cell lines. Cell proliferation a
Publikováno v:
Cytometry. Part A : the journal of the International Society for Analytical Cytology. 93(2)
Complex analysis of cellular responses after experimental treatment is important for screening, mechanistic understanding of treatment effects, and the identification of sensitive and resistant cell phenotypes. Modern multicolor flow cytometry has de
Autor:
Michela Muscettola, Sara Salvadori, Nila Volpi, Emanuela Maioli, Karel Souček, Claudia Torricelli, Eva Slabáková, Giuseppe Valacchi
Publikováno v:
Evidence-Based Complementary and Alternative Medicine, Vol 2012 (2012)
Evidence-based Complementary and Alternative Medicine : eCAM
Evidence-based Complementary and Alternative Medicine : eCAM
Since the ability of cancer cells to evade apoptosis often limits the efficacy of radiotherapy and chemotherapy, autophagy is emerging as an alternative target to promote cell death. Therefore, we wondered whether Rottlerin, a natural polyphenolic co
Autor:
János Szöllősi, Viktor Horváth, Jiřina Hofmanová, Alois Kozubík, Ladislav Anděra, Alena Hyršlová Vaculová, György Vereb, Petr Sova, Olga Vondálová Blanářová, Karel Souček, Árpád Szöőr, Belma Skender, Iva Jelínková
Publikováno v:
Carcinogenesis. 32:42-51
TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) can selectively trigger apoptosis in various cancer cell types. However, many cancer cells are resistant to death receptor-mediated apoptosis. Combination therapy with platinum complexes
Autor:
Jaromír Mikeš, Rastislav Jendželovský, Peter Fedoročko, Jiřina Procházková, Ján Koval, Karel Souček, Jiřina Hofmanová, Veronika Sačková, Alois Kozubík, Martin Kello
Publikováno v:
Photochemical & Photobiological Sciences. 8:1716-1723
Photodynamic therapy (PDT) is a flexible multi-target therapeutic approach. One of the main requirements of successful PDT is sufficient intracellular concentration of an applicable photosensitizer. Mechanisms of anticancer drug elimination by tumour
Publikováno v:
European Journal of Haematology. 83:35-47
The block of hematopoietic differentiation program in acute myeloid leukemia cells can be overcome by differentiating agent like retinoic acid, but it has several side effects. A study of other differentiation signaling pathways is therefore useful t
Autor:
Jana Slováčková, Jan Šmarda, Eva Ondroušková, Jiřina Procházková, Vendula Pelková, Karel Souček, Petr Beneš
Publikováno v:
bchm. 390:49-58
The Bcl-2 protein is one of the key components of biochemical pathways controlling programmed cell death. The function of this protein can be regulated by posttranslational modifications. Phosphorylation of Bcl-2 has been considered to be significant