Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Hisashi Yamada"'
Autor:
Masanobu Kitagawa, Kouhei Yamamoto, Keisuke Aiba, Hisashi Yamada, Kazuhito Suzuki, Yasuhiro Arakawa
Publikováno v:
Anti-Cancer Drugs
Supplemental Digital Content is available in the text.
Bromodomain and extraterminal protein (BET) inhibitors suppress the expression of c-MYC. U266, a human myeloma cell line, expresses the MYCL gene, but not the c-MYC gene. Our aim was to anal
Bromodomain and extraterminal protein (BET) inhibitors suppress the expression of c-MYC. U266, a human myeloma cell line, expresses the MYCL gene, but not the c-MYC gene. Our aim was to anal
Autor:
Hisashi Yamada, Kotaro Hishiki, Emi Tsuchitani, Masaharu Akiyama, Yumi Kanegae, Koji Ozaki, Ken Kaito, Miyuki Ohta
Publikováno v:
Leukemia research. 74
Novel epigenetic therapies targeting bromodomain and extra-terminal (BET) family proteins have shown therapeutic efficacy in diverse hematologic malignancies and solid cancers. However, the mechanism of resistance remains poorly understood. In the pr
Autor:
Tetsuro Kikuchi, Tetsuya Kawamura, Tsuneya Ohno, Tatsuo Hosoya, Nobuo Tsuboi, Hisashi Yamada, Yasunori Utsunomiya
Publikováno v:
Kidney International. 63(3):936-946
Shedding of growth-suppressive gangliosides from glomerular mesangial cells undergoing apoptosis. Background Apoptosis of glomerular mesangial cells is a common feature in several types of glomerular diseases. However, its pathophysiologic significan
Autor:
Makoto Nagai, Sachiko Fukumi, Shuji Nakada, Tsuneya Ohno, Junko Horiguchi-Yamada, Hisashi Yamada
Publikováno v:
Molecular and Cellular Biochemistry. 206:43-50
Etoposide is a potent anticancer agent that is used to treat various tumors. We have investigated the dose-dependent effect of etoposide on apoptosis using chronic myeloid leukemia K562 cells treated with low (5 μM) or high (100 μM) concentrations
Autor:
Hisashi Yamada, Hideaki Mizoguchi, Yasutaka Hoshi, Masaharu Akiyama, Shinobu Saito, O Yamada, Junko Horiguchi-Yamada
Publikováno v:
European Journal of Cancer. 35:309-315
Telomerase, the enzyme that maintains the ends of linear eukaryotic chromosomes, is more active in the majority of malignant tumours than in normal somatic cells. Telomerase plays a key role in the maintenance of chromosomal stability in tumours, but
Autor:
Makoto Nagai, Shinobu Takahara, Junko Horiguchi-Yamada, Satsuki Iwase, Tetsuaki Sekikawa, Takeshi Kawano, Hisashi Yamada, Sachiko Fukumi, Kiyoshi Itoh
Publikováno v:
Molecular and Cellular Biochemistry. 187:211-220
Therapeutic strategies for leukemia are directed to induction of differentiation and apoptosis as well as growth inhibition. One of the key antileukemic agents, 1-β-D-arabinofuranosylcytosine (ara C), is clinically applied according to these therape
Publikováno v:
Oncology Reports
Various anticancer drugs, including camptothecins and indolocarbazoles, target DNA topoisomerase I (Top1). We previously described the camptothecin-resistant colon cancer cell line DLDSNR6, which has a Gly365Ser missense mutation in Top1. In the pres
Autor:
Kiyotaka Kawauchi, Takeshi Kawano, Masaharu Akiyama, Hiroyuki Ida, Hisashi Yamada, Osamu Yamada, Kohji Ozaki
Publikováno v:
Cancer letters. 340(1)
The molecular mechanism of telomerase activation induced by ionizing radiation (IR) remains poorly understood. We demonstrate that DNA damage induced by IR at doses of 2–5 Gy triggers activation of Akt, predominant to that of protein phosphatase 2A
Autor:
Masaharu Akiyama, Osamu Yamada, Kiyotaka Kawauchi, Toshiko Motoji, Tsuyoshi Mitsuishi, Rumiko Matsuoka, Kohji Ozaki, Hisashi Yamada, Mitsuyo Machida, Thoru Furukawa, Yan Hua Wang
Publikováno v:
Cellular signalling. 23(7)
We used two imatinib resistant cell lines, K562-ADM cells, which over-express P-glycoprotein (a product of the ABCB1 gene, more commonly known as MDR1), and K562-hTERT cells, which over-express the telomerase reverse transcriptase (TERT), as models t
Autor:
Yoko Mikami-Terao, Satsuki Iwase, Naoki Agata, Hiroyuki Ida, Miyuki Agawa-Ohta, Takaaki Yanagisawa, Hisashi Yamada, Takeshi Kawano, Masaharu Akiyama
Publikováno v:
International Journal of Oncology. 37
Although p53 is intact in most cases of retinoblastoma, it is largely inactivated by the ubiqutin-proteasome system through interaction with murine double minute 2 (MDM2) and murine double minute X (MDMX). The present study showed that the histone de