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Publikováno v:
BMB Reports
Nucleotide-binding oligomerization domain protein 2 (NOD2), an intracellular pattern recognition receptor, plays important roles in inflammation and cell death. Previously, we have shown that NOD2 is expressed in vascular smooth muscle cells (VSMCs)
Loss of non‐canonical KCC2 functions promotes developmental apoptosis of cortical projection neurons
Publikováno v:
EMBO Rep
KCC2, encoded in humans by the SLC12A5 gene, is a multifunctional neuron-specific protein initially identified as the chloride (Cl-) extruder critical for hyperpolarizing GABA(A) receptor currents. Independently of its canonical function as a K-Cl co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5199543e80bb8bb52c2871214a9a25f
https://europepmc.org/articles/PMC7132201/
https://europepmc.org/articles/PMC7132201/
Autor:
Martin C. Sadowski, Rohan A. Davis, Melanie Lehman, Claire Levrier, Colleen C. Nelson, Brian Gabrielli, Anja Rockstroh, Maria Kavallaris
Publikováno v:
Cell Cycle
We report for the first time the mechanism of action of the natural product thalicthuberine (TH) in prostate and cervical cancer cells. TH induced a strong accumulation of LNCaP cells in mitosis, severe mitotic spindle defects, and asymmetric cell di
Publikováno v:
Cell Cycle
LncRNA in non-homologous end joining (NHEJ) pathway 1 (LINP1) is an lncRNA which promotes therapeutic resistance in triple-negative breast cancer (TNBC). However, the expression and function of LINP1 in cervical cancer is not yet well-understood. In
Autor:
Amriti R. Lulla, Jeffrey J. Pu, Jawad Babar, Nadia Khan, Cyril H. Benes, Lanlan Zhou, Joshua E. Allen, A. Pieter J. van den Heuvel, Ultan McDermott, Mala K. Talekar, Mathew J. Garnett, C. Leah B. Kline, Junior Hall, Wolfgang Oster, David F. Claxton, Varun V. Prabhu, David T. Dicker, Wafik S. El-Deiry, Stephan A. Grupp
Publikováno v:
Cell Cycle. 17:468-478
ONC201, founding member of the imipridone class of small molecules, is currently being evaluated in advancer cancer clinical trials. We explored single agent and combinatorial efficacy of ONC201 in preclinical models of hematological malignancies. ON
Autor:
Zhongxian Zhu, Zechao Wen, Hongxing Li, Yankai Xia, Qiyang Shen, Lei Peng, Chunxia Du, Weibing Tang, Hua Zhang, Yang Su, Hua Xie, Guanglin Chen
Publikováno v:
Cell Cycle. 17:459-467
Recently studies reported that long non-coding RNAs (lncRNAs) may take part in a lot of congenital diseases, meanwhile, Hirschsprung's disease (HSCR) is a major congenital digestive tract malformation. Nevertheless whether lncRNAs participate in the
Publikováno v:
Cell Cycle. 17:43-52
Cdc20 (cell division cycle 20 homologue) has been reported to exhibit an oncogenic role in human tumorigenesis. However, the function of Cdc20 in osteosarcoma (OS) has not been investigated. In the current study, we aim to explore the role of Cdc20 i
Autor:
Nikolai A. Barlev, Alexey Petukhov, Nikolai V Panyushev, Kirill V. Volkov, Alina D. Nikotina, Nikolai D. Aksenov, Mittenberg Ag, Daria Kriger, M.G. Khotin, Dmitri Tentler, Turoverova Lv, Ekaterina Lomert
Publikováno v:
Cell Cycle. :01-21
Alpha-actinin 4 (ACTN4) is an actin-binding protein of the spectrin superfamily. ACTN4 is found both in the cytoplasm and nucleus of eukaryotic cells. The main function of cytoplasmic ACTN4 is stabilization of actin filaments and their binding to foc
Publikováno v:
Cell Cycle. 16:968-978
Viruses can interact with host cell molecules responsible for the recognition and repair of DNA lesions, resulting in dysfunctional DNA damage response (DDR). Cells with inefficient DDR are more vulnerable to therapeutic approaches that target DDR, t
Autor:
Yu Zhou, Junchao Kong, Juan-Hua Quan, Ge Shi, Shou-Quan Yan, Rui Huang, Kaipeng Jing, Yi-Ming Fan, Cai-Yuan Yu, Jia-Qi Chu, Young-Ha Lee, Peng Li, Yanru Niu, Xiang Gao
Publikováno v:
Cell Cycle. 16:477-486
Autophagy and apoptosis are critical for controlling Toxoplasma gondii (T. gondii) infection. T. gondii infection during pregnancy can damage the fetus and cause birth defects; however, the molecular mechanisms of this process are poorly understood.